E G Abucayon1, R L Khade2, D R Powell1, M J Shaw3, Y Zhang2, G B Richter-Addo1. 1. Department of Chemistry and Biochemistry, University of Oklahoma, Norman, Oklahoma 73019, USA. grichteraddo@ou.edu. 2. Department of Biomedical Engineering, Chemistry and Biological Sciences, Stevens Institute of Technology, Castle Point on Hudson, Hoboken, New Jersey 07030, USA. yong.zhang@stevens.edu. 3. Department of Chemistry, Southern Illinois University Edwardsville, Edwardsville, Illinois 62025, USA.
Abstract
Hydride attack at a ferric heme-NO to give an Fe-HNO intermediate is a key step in the global N-cycle. We demonstrate differential reactivity when six- and five-coordinate ferric heme-NO models react with hydride. Although Fe-HNO formation is thermodynamically favored from this reaction, Fe-H formation is kinetically favored for the 5C case.
Hydride attack at a pan class="Chemical">ferric heme-NO to give an pan class="Chemical">Fe-HNO intermediate is a key step in the global N-cycle. We demonstrate differential reactivity when six- and five-coordinate ferric heme-NO models react with hydride. Although Fe-HNO formation is thermodynamically favored from this reaction, Fe-H formation is kinetically favored for the 5C case.
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