Yong Zhang1. 1. Department of Chemistry, Chemical Biology, and Biomedical Engineering, Stevens Institute of Technology, 1 Castle Point on Hudson, Hoboken, NJ 07030, USA. yong.zhang@stevens.edu
Abstract
HNO (nitroxyl) has been found to have many physiological effects in numerous biological processes. Computational investigations have been employed to help understand the structural properties of HNO complexes and HNO reactivities in some interesting biologically relevant systems. The following computational aspects were reviewed in this work: 1) structural and energetic properties of HNO isomers; 2) interactions between HNO and non-metal molecules; 3) structural and spectroscopic properties of HNO metal complexes; 4) HNO reactions with biologically important non-metal systems; 5) involvement of HNO in reactions of metal complexes and metalloproteins. Results indicate that computational investigations are very helpful to elucidate interesting experimental phenomena and provide new insights into unique structural, spectroscopic, and mechanistic properties of HNO involvement in biology.
HNO (n class="Chemical">nitroxyl) has been found to have many physiological effects in numerous biological processes. Computational investigations have been employed to help understand the structural properties of HNO complexes and HNO reactivities in some interesting biologically relevant systems. The following computational aspects were reviewed in this work: 1) structural and energetic properties of HNO isomers; 2) interactions between HNO and non-metal molecules; 3) structural and spectroscopic properties of HNOmetal complexes; 4) HNO reactions with biologically important non-metal systems; 5) involvement of HNO in reactions of metal complexes and metalloproteins. Results indicate that computational investigations are very helpful to elucidate interesting experimental phenomena and provide new insights into unique structural, spectroscopic, and mechanistic properties of HNO involvement in biology.
Authors: Junhong Mao; Sujoy Mukherjee; Yong Zhang; Rong Cao; John M Sanders; Yongcheng Song; Yonghui Zhang; Gary A Meints; Yi Gui Gao; Dushyant Mukkamala; Michael P Hudock; Eric Oldfield Journal: J Am Chem Soc Date: 2006-11-15 Impact factor: 15.419
Authors: Andrea C Montenegro; Valentín T Amorebieta; Leonardo D Slep; Diego F Martín; Federico Roncaroli; Daniel H Murgida; Sara E Bari; José A Olabe Journal: Angew Chem Int Ed Engl Date: 2009 Impact factor: 15.336
Authors: Thomas W Miller; Melisa M Cherney; Andrea J Lee; Nestor E Francoleon; Patrick J Farmer; S Bruce King; Adrian J Hobbs; Katrina M Miranda; Judith N Burstyn; Jon M Fukuto Journal: J Biol Chem Date: 2009-06-15 Impact factor: 5.157
Authors: Erwin G Abucayon; Rahul L Khade; Douglas R Powell; Yong Zhang; George B Richter-Addo Journal: J Am Chem Soc Date: 2015-12-23 Impact factor: 15.419
Authors: Matthew A Michael; Gianna Pizzella; Liu Yang; Yelu Shi; Tiffany Evangelou; Daniel T Burke; Yong Zhang Journal: J Phys Chem Lett Date: 2014-03-07 Impact factor: 6.475