Literature DB >> 26853882

Comparison of design strategies for α-helix backbone modification in a protein tertiary fold.

Nathan A Tavenor1, Zachary E Reinert1, George A Lengyel1, Brian D Griffith1, W Seth Horne1.   

Abstract

We report here the comparison of five classes of unnatural amino acid building blocks for their ability to be accommodated into an α-helix in a protein tertiary fold context. High-resolution structural characterization and analysis of folding thermodynamics yield new insights into the relationship between backbone composition and folding energetics in α-helix mimetics and suggest refined design rules for engineering the backbones of natural sequences.

Entities:  

Mesh：

Substances：

Year:  2016        PMID： 26853882      PMCID： PMC4767680          DOI： 10.1039/c6cc00273k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  40 in total

1.  Helical screw-sense preferences of peptides based on chiral, Cα-tetrasubstituted α-amino acids.

Authors:  Marco Crisma; Claudio Toniolo
Journal:  Biopolymers       Date:  2015-01       Impact factor: 2.505

2.  Peptide and peptoid foldamers in medicinal chemistry.

Authors:  W Seth Horne
Journal:  Expert Opin Drug Discov       Date:  2011-11-02       Impact factor: 6.098

3.  Interplay among side chain sequence, backbone composition, and residue rigidification in polypeptide folding and assembly.

Authors:  W Seth Horne; Joshua L Price; Samuel H Gellman
Journal:  Proc Natl Acad Sci U S A       Date:  2008-06-27       Impact factor: 11.205

4.  Global analysis of the thermal and chemical denaturation of the N-terminal domain of the ribosomal protein L9 in H2O and D2O. Determination of the thermodynamic parameters, deltaH(o), deltaS(o), and deltaC(o)p and evaluation of solvent isotope effects.

Authors:  B Kuhlman; D P Raleigh
Journal:  Protein Sci       Date:  1998-11       Impact factor: 6.725

5.  Hairpin folding behavior of mixed α/β-peptides in aqueous solution.

Authors:  George A Lengyel; Rebecca C Frank; W Seth Horne
Journal:  J Am Chem Soc       Date:  2011-03-03       Impact factor: 15.419

6.  Design and high-resolution structure of a β³-peptide bundle catalyst.

Authors:  Pam S P Wang; Jennifer B Nguyen; Alanna Schepartz
Journal:  J Am Chem Soc       Date:  2014-05-06       Impact factor: 15.419

7.  Enhanced protein thermostability by Ala-->Aib replacement.

Authors:  V De Filippis; F De Antoni; M Frigo; P Polverino de Laureto; A Fontana
Journal:  Biochemistry       Date:  1998-02-10       Impact factor: 3.162

8.  Interplay of hydrogen bonds and n→π* interactions in proteins.

Authors:  Gail J Bartlett; Robert W Newberry; Brett VanVeller; Ronald T Raines; Derek N Woolfson
Journal:  J Am Chem Soc       Date:  2013-12-03       Impact factor: 15.419

9.  Factors governing helical preference of peptides containing multiple alpha,alpha-dialkyl amino acids.

Authors:  G R Marshall; E E Hodgkin; D A Langs; G D Smith; J Zabrocki; M T Leplawy
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

10.  Crystal polymorphism of protein GB1 examined by solid-state NMR spectroscopy and X-ray diffraction.

Authors:  Heather L Frericks Schmidt; Lindsay J Sperling; Yi Gui Gao; Benjamin J Wylie; John M Boettcher; Scott R Wilson; Chad M Rienstra
Journal:  J Phys Chem B       Date:  2007-12-04       Impact factor: 2.991
View more
  15 in total

1.  Thermodynamic and Structural Impact of α,α-Dialkylated Residue Incorporation in a β-Hairpin Peptide.

Authors:  Megan A Karnes; Shelby L Schettler; Halina M Werner; Alana F Kurz; W Seth Horne; George A Lengyel
Journal:  Org Lett       Date:  2016-07-20       Impact factor: 6.005

2.  Thermodynamic Scale of β-Amino Acid Residue Propensities for an α-Helix-like Conformation.

Authors:  Brian F Fisher; Seong Ho Hong; Samuel H Gellman
Journal:  J Am Chem Soc       Date:  2018-07-19       Impact factor: 15.419

3.  Heterogeneous-Backbone Foldamer Mimics of Zinc Finger Tertiary Structure.

Authors:  Kelly L George; W Seth Horne
Journal:  J Am Chem Soc       Date:  2017-06-05       Impact factor: 15.419

4.  Designing cooperatively folded abiotic uni- and multimolecular helix bundles.

Authors:  Soumen De; Bo Chi; Thierry Granier; Ting Qi; Victor Maurizot; Ivan Huc
Journal:  Nat Chem       Date:  2017-09-18       Impact factor: 24.427

5.  Receptor selectivity from minimal backbone modification of a polypeptide agonist.

Authors:  Shi Liu; Ross W Cheloha; Tomoyuki Watanabe; Thomas J Gardella; Samuel H Gellman
Journal:  Proc Natl Acad Sci U S A       Date:  2018-11-15       Impact factor: 11.205

6.  Foldamer Tertiary Structure through Sequence-Guided Protein Backbone Alteration.

Authors:  Kelly L George; W Seth Horne
Journal:  Acc Chem Res       Date:  2018-04-19       Impact factor: 22.384

7.  Heterogeneous-Backbone Foldamer Mimics of a Computationally Designed, Disulfide-Rich Miniprotein.

Authors:  Chino C Cabalteja; Daniel S Mihalko; W Seth Horne
Journal:  Chembiochem       Date:  2018-11-27       Impact factor: 3.164

Review 8.  Systematic Targeting of Protein-Protein Interactions.

Authors:  Ashley E Modell; Sarah L Blosser; Paramjit S Arora
Journal:  Trends Pharmacol Sci       Date:  2016-06-04       Impact factor: 14.819

9.  Differential Effects of β3 - versus β2 -Amino Acid Residues on the Helicity and Recognition Properties of Bim BH3-Derived α/β-Peptides.

Authors:  Geoffrey A Eddinger; Samuel H Gellman
Journal:  Angew Chem Int Ed Engl       Date:  2018-09-20       Impact factor: 15.336

10.  Advancing the Frontiers of Chemical Protein Synthesis-The 7th CPS Meeting, Haifa, Israel.

Authors:  Anne C Conibear; Markus Muttenthaler
Journal:  Cell Chem Biol       Date:  2018-03-15       Impact factor: 8.116
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.