Literature DB >> 26141752

The administration of nasal drops in the "Kaiteki" position allows for delivery of the drug to the olfactory cleft: a pilot study in healthy subjects.

Eri Mori1,2, Christos Merkonidis3, Mandy Cuevas4, Volker Gudziol4, Yoshinori Matsuwaki5, Thomas Hummel6.   

Abstract

Systemic treatment with corticosteroids shows therapeutic effects, few patients benefit from intranasal topical drug application, probably due to limited access of the drug to the olfactory epithelium. The aim of the present study was to investigate how drops distribute within the nasal cavity when the "Kaiteki" position is performed. Thirteen healthy volunteers participated. Subjects were lying on the side with the head tilted and the chin turned upward. Blue liquid was used to visualize the intranasal distribution of the nasal drops. The investigation was carried out using photo documentation thorough nasal endoscopy; the intranasal distribution of the dye was judged by two independent observers in both a decongested state and a natural state where no decongestants had been used. With regard to the main criterion of this study, using the "Kaiteki" position, nasal drops reached the olfactory cleft in 96 % of the decongested cases and 75 % of the cases who had not been decongested. However, this difference was not statistically different. Because the "Kaiteki" maneuver is not too difficult to perform, it is more likely that topical steroids can be helpful in cases of olfactory loss.

Entities:  

Keywords:  Nasal drop; Olfaction; Olfactory cleft; Position; Smell

Mesh:

Substances:

Year:  2015        PMID: 26141752     DOI: 10.1007/s00405-015-3701-y

Source DB:  PubMed          Journal:  Eur Arch Otorhinolaryngol        ISSN: 0937-4477            Impact factor:   2.503


  17 in total

1.  The effect of head position on the distribution of drops within the nose.

Authors:  H Kubba; E Spinou; A Robertson
Journal:  Am J Rhinol       Date:  2000 Mar-Apr

2.  Delivery of nasal drops to the middle meatus: which is the best head position?

Authors:  Y G Karagama; J L Lancaster; A Karkanevatos; G O'Sullivan
Journal:  Rhinology       Date:  2001-12       Impact factor: 3.681

Review 3.  Anti-inflammatory and surgical therapy of olfactory disorders related to sino-nasal disease.

Authors:  Markus Wolfensberger; Thomas Hummel
Journal:  Chem Senses       Date:  2002-09       Impact factor: 3.160

4.  Comparison of nasal sprays and irrigations in the delivery of topical agents to the olfactory mucosa.

Authors:  Kent Lam; Bruce K Tan; Jennifer M Lavin; Eric Meen; David B Conley
Journal:  Laryngoscope       Date:  2013-06-28       Impact factor: 3.325

5.  An evaluation of the best head position for instillation of steroid nose drops.

Authors:  R Kayarkar; N J Clifton; T J Woolford
Journal:  Clin Otolaryngol Allied Sci       Date:  2002-02

6.  Olfactory cleft opacity and CT score are predictive factors of smell recovery after surgery in nasal polyposis.

Authors:  C Vandenhende-Szymanski; B Hochet; D Chevalier; G Mortuaire
Journal:  Rhinology       Date:  2015-03       Impact factor: 3.681

7.  Prevalence of olfactory impairment in older adults.

Authors:  Claire Murphy; Carla R Schubert; Karen J Cruickshanks; Barbara E K Klein; Ronald Klein; David M Nondahl
Journal:  JAMA       Date:  2002-11-13       Impact factor: 56.272

8.  Placebo-controlled, randomized, double-blind study evaluating the efficacy of fluticasone propionate nasal spray for the treatment of patients with hyposmia/anosmia.

Authors:  Ebba Hedén Blomqvist; Lars Lundblad; Hans Bergstedt; Pär Stjärne
Journal:  Acta Otolaryngol       Date:  2003-09       Impact factor: 1.494

9.  Intranasal administration of drugs.

Authors:  Mandy Scheibe; Christopher Bethge; Martin Witt; Thomas Hummel
Journal:  Arch Otolaryngol Head Neck Surg       Date:  2008-06

10.  Techniques of intranasal steroid use.

Authors:  Michael S Benninger; James A Hadley; J David Osguthorpe; Bradley F Marple; Donald A Leopold; M Jennifer Derebery; Maureen Hannley
Journal:  Otolaryngol Head Neck Surg       Date:  2004-01       Impact factor: 5.591

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  11 in total

1.  First Steps to Develop and Validate a CFPD Model in Order to Support the Design of Nose-to-Brain Delivered Biopharmaceuticals.

Authors:  Lucas Engelhardt; Martina Röhm; Chrystelle Mavoungou; Katharina Schindowski; Annette Schafmeister; Ulrich Simon
Journal:  Pharm Res       Date:  2016-02-17       Impact factor: 4.200

2.  Olfaction in chronic rhinosinusitis: comparing two different endonasal steroid application methods.

Authors:  Sophia C Poletti; Islam Batashev; Jens Reden; Thomas Hummel
Journal:  Eur Arch Otorhinolaryngol       Date:  2016-10-11       Impact factor: 2.503

Review 3.  Anosmia-A Clinical Review.

Authors:  Sanne Boesveldt; Elbrich M Postma; Duncan Boak; Antje Welge-Luessen; Veronika Schöpf; Joel D Mainland; Jeffrey Martens; John Ngai; Valerie B Duffy
Journal:  Chem Senses       Date:  2017-09-01       Impact factor: 3.160

4.  Treatment strategies for postviral olfactory dysfunction: A systematic review.

Authors:  Samuel N Helman; Jonah Adler; Aria Jafari; Sasha Bennett; Jackson R Vuncannon; Ashley C Cozart; Sarah K Wise; Merin E Kuruvilla; Joshua M Levy
Journal:  Allergy Asthma Proc       Date:  2022-03-01       Impact factor: 2.587

Review 5.  Olfaction: Sensitive indicator of inflammatory burden in chronic rhinosinusitis.

Authors:  Xiaoguang Yan; Katherine Lisa Whitcroft; Thomas Hummel
Journal:  Laryngoscope Investig Otolaryngol       Date:  2020-10-28

Review 6.  Current Perspective on Nasal Delivery Systems for Chronic Rhinosinusitis.

Authors:  Junhu Tai; Kijeong Lee; Tae Hoon Kim
Journal:  Pharmaceutics       Date:  2021-02-10       Impact factor: 6.321

Review 7.  Management of post-COVID-19 olfactory dysfunction.

Authors:  Tara J Wu; Alice C Yu; Jivianne T Lee
Journal:  Curr Treat Options Allergy       Date:  2022-01-04

8.  [Olfactory and gustatory disorders].

Authors:  M M Speth; U S Speth; A R Sedaghat; T Hummel
Journal:  HNO       Date:  2022-01-12       Impact factor: 1.284

9.  Liquid Film Translocation Significantly Enhances Nasal Spray Delivery to Olfactory Region: A Numerical Simulation Study.

Authors:  Xiuhua April Si; Muhammad Sami; Jinxiang Xi
Journal:  Pharmaceutics       Date:  2021-06-18       Impact factor: 6.321

10.  The Effect of Endoscopic Olfactory Cleft Opening on Obstructed Olfactory Cleft Disease.

Authors:  Rong-San Jiang; Kai-Li Liang
Journal:  Int J Otolaryngol       Date:  2020-03-27
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