Literature DB >> 11826694

Delivery of nasal drops to the middle meatus: which is the best head position?

Y G Karagama1, J L Lancaster, A Karkanevatos, G O'Sullivan.   

Abstract

BACKGROUND: Chronic sinusitis and intranasal polyps require long-term topical drug therapy. The issue of drug delivery to the critical area of the middle meatus is rarely addressed. AIM: The aim of this study was to compare the delivery of drops to the middle meatus using four different head positions (Mecca, Mygind, Ragan and Head back). The study also assessed the discomfort with each position whilst administering the nasal drops.
METHODS: Nine nostrils in five healthy volunteers were studied to compare the delivery of drops to the middle meatus using the four different head positions. A neurosurgical patty was placed under direct vision in the middle meatus using a rigid nasendoscope. Six drops of dyed-saline were administered into each nostril. Upon removal, a quantitative assessment was made of the amount of dye absorbed and discomfort assessed. The direction of flow of the nasal drops in the nose was also demonstrated.
RESULTS: The 'Mygind' and 'Ragan' positions were superior to the 'Mecca' and 'Head back' positions in delivery of drops to the middle meatus. The 'Mecca' position was the most uncomfortable.
CONCLUSION: We recommend that the 'Mygind' or 'Ragan' position should be used for nasal drop administration.

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Year:  2001        PMID: 11826694

Source DB:  PubMed          Journal:  Rhinology        ISSN: 0300-0729            Impact factor:   3.681


  7 in total

1.  Influence of anatomy and head position on intranasal drug deposition.

Authors:  Paul Merkus; Fenna A Ebbens; Barbara Muller; Wytske J Fokkens
Journal:  Eur Arch Otorhinolaryngol       Date:  2006-06-29       Impact factor: 2.503

2.  The administration of nasal drops in the "Kaiteki" position allows for delivery of the drug to the olfactory cleft: a pilot study in healthy subjects.

Authors:  Eri Mori; Christos Merkonidis; Mandy Cuevas; Volker Gudziol; Yoshinori Matsuwaki; Thomas Hummel
Journal:  Eur Arch Otorhinolaryngol       Date:  2015-07-04       Impact factor: 2.503

Review 3.  Update on Intranasal Medications in Rhinosinusitis.

Authors:  Kornkiat Snidvongs; Sanguansak Thanaviratananich
Journal:  Curr Allergy Asthma Rep       Date:  2017-07       Impact factor: 4.806

4.  Efficacy of corticosteroid solution administration via Mygind's position for the management of chronic rhinosinusitis with nasal polyps.

Authors:  Ashwini M Tilak; Spencer C Payne
Journal:  Laryngoscope Investig Otolaryngol       Date:  2020-08-07

5.  Topical Drug Delivery for Chronic Rhinosinusitis.

Authors:  Jonathan Liang; Andrew P Lane
Journal:  Curr Otorhinolaryngol Rep       Date:  2012-12-27

6.  Physiology and pathophysiology of respiratory mucosa of the nose and the paranasal sinuses.

Authors:  Achim G Beule
Journal:  GMS Curr Top Otorhinolaryngol Head Neck Surg       Date:  2011-04-27

Review 7.  Novel drug-delivery systems for patients with chronic rhinosinusitis.

Authors:  Silviu Albu
Journal:  Drug Des Devel Ther       Date:  2012-05-31       Impact factor: 4.162

  7 in total

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