Peter A Wassenaar1, Chethanya N Eleswarpu1,2, Samuel A Schroeder1,3, Xiaokui Mo4, Brian D Raterman1, Richard D White1,5, Arunark Kolipaka1,2,5. 1. Department of Radiology, The Ohio State University College of Medicine, Columbus, Ohio, USA. 2. Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, USA. 3. Department of Mechanical Engineering, The Ohio State University, Columbus, Ohio, USA. 4. Center for Biostatistics, The Ohio State University, Columbus, Ohio, USA. 5. Department of Internal Medicine-Division of Cardiovascular Medicine, The Ohio State University College of Medicine, Columbus, Ohio, USA.
Abstract
PURPOSE: To assess reproducibility in measuring left ventricular (LV) myocardial stiffness in volunteers throughout the cardiac cycle using MR elastography (MRE) and to determine its correlation with age. METHODS: Cardiac MRE (CMRE) was performed on 29 normal volunteers, with ages ranging from 21 to 73 years. For assessing reproducibility of CMRE-derived stiffness measurements, scans were repeated per volunteer. Wave images were acquired throughout the LV myocardium, and were analyzed to obtain mean stiffness during the cardiac cycle. CMRE-derived stiffness values were correlated to age. RESULTS: Concordance correlation coefficient revealed good interscan agreement with rc of 0.77, with P-value < 0.0001. Significantly higher myocardial stiffness was observed during end-systole (ES) compared with end-diastole (ED) across all subjects. Additionally, increased deviation between ES and ED stiffness was observed with increased age. CONCLUSION: CMRE-derived stiffness is reproducible, with myocardial stiffness changing cyclically across the cardiac cycle. Stiffness is significantly higher during ES compared with ED. With age, ES myocardial stiffness increases more than ED, giving rise to an increased deviation between the two.
PURPOSE: To assess reproducibility in measuring left ventricular (LV) myocardial stiffness in volunteers throughout the cardiac cycle using MR elastography (MRE) and to determine its correlation with age. METHODS: Cardiac MRE (CMRE) was performed on 29 normal volunteers, with ages ranging from 21 to 73 years. For assessing reproducibility of CMRE-derived stiffness measurements, scans were repeated per volunteer. Wave images were acquired throughout the LV myocardium, and were analyzed to obtain mean stiffness during the cardiac cycle. CMRE-derived stiffness values were correlated to age. RESULTS: Concordance correlation coefficient revealed good interscan agreement with rc of 0.77, with P-value < 0.0001. Significantly higher myocardial stiffness was observed during end-systole (ES) compared with end-diastole (ED) across all subjects. Additionally, increased deviation between ES and ED stiffness was observed with increased age. CONCLUSION: CMRE-derived stiffness is reproducible, with myocardial stiffness changing cyclically across the cardiac cycle. Stiffness is significantly higher during ES compared with ED. With age, ES myocardial stiffness increases more than ED, giving rise to an increased deviation between the two.
Authors: Li Pan; Matthias Stuber; Dara L Kraitchman; Danielle L Fritzges; Wesley D Gilson; Nael F Osman Journal: Magn Reson Med Date: 2006-02 Impact factor: 4.668
Authors: Roberto M Lang; Michelle Bierig; Richard B Devereux; Frank A Flachskampf; Elyse Foster; Patricia A Pellikka; Michael H Picard; Mary J Roman; James Seward; Jack Shanewise; Scott Solomon; Kirk T Spencer; Martin St John Sutton; William Stewart Journal: Eur J Echocardiogr Date: 2006-02-02
Authors: Scott A Kruse; Gregory H Rose; Kevin J Glaser; Armando Manduca; Joel P Felmlee; Clifford R Jack; Richard L Ehman Journal: Neuroimage Date: 2007-08-29 Impact factor: 6.556
Authors: Arunark Kolipaka; Kiaran P McGee; Philip A Araoz; Kevin J Glaser; Armando Manduca; Richard L Ehman Journal: Magn Reson Med Date: 2009-09 Impact factor: 4.668
Authors: Meng Yin; Jayant A Talwalkar; Kevin J Glaser; Armando Manduca; Roger C Grimm; Phillip J Rossman; Jeff L Fidler; Richard L Ehman Journal: Clin Gastroenterol Hepatol Date: 2007-10 Impact factor: 11.382
Authors: Arunark Kolipaka; Venkata Sita Priyanka Illapani; Prateek Kalra; Julio Garcia; Xiaokui Mo; Michael Markl; Richard D White Journal: J Magn Reson Imaging Date: 2016-09-07 Impact factor: 4.813
Authors: Benjamin A Walter; Prasath Mageswaran; Xiaokui Mo; Daniel J Boulter; Hazem Mashaly; Xuan V Nguyen; Luciano M Prevedello; William Thoman; Brian D Raterman; Prateek Kalra; Ehud Mendel; William S Marras; Arunark Kolipaka Journal: Radiology Date: 2017-05-04 Impact factor: 11.105
Authors: Arunark Kolipaka; Venkata Sita Priyanka Illapani; William Kenyhercz; Joshua D Dowell; Michael R Go; Jean E Starr; Patrick S Vaccaro; Richard D White Journal: J Vasc Surg Date: 2016-04-27 Impact factor: 4.268
Authors: Arvin Arani; Kevin L Glaser; Shivaram P Arunachalam; Phillip J Rossman; David S Lake; Joshua D Trzasko; Armando Manduca; Kiaran P McGee; Richard L Ehman; Philip A Araoz Journal: Magn Reson Med Date: 2016-01-17 Impact factor: 4.668