Ria Mazumder1,2,3, Samuel Schroeder2,4, Xiaokui Mo5, Bradley D Clymer1, Richard D White2,6, Arunark Kolipaka2,6. 1. Department of Electrical and Computer Engineering, 205 Dreese Laboratories, The Ohio State University, Columbus, Ohio, USA. 2. Department of Radiology, Room 460, The Ohio State University, Columbus, Ohio, USA. 3. Department of Biomedical Engineering, 265 Kirkbride Hall, Walnut Street, Widener University, Chester, PA. 4. Department of Mechanical Engineering, The Ohio State University, Columbus, Ohio, USA. 5. Center for Biostatistics, Department of Biomedical Informatics, Room 320D, Lincoln Tower, Columbus, Ohio, USA. 6. Department of Internal Medicine-Division of Cardiovascular Medicine, 244 Davis Heart & Lung Research Institute, The Ohio State University, Columbus, Ohio, USA.
Abstract
PURPOSE: To determine alteration in left ventricular (LV) myocardial stiffness (MS) with hypertension (HTN). Cardiac MR elastography (MRE) was used to estimate MS in HTN induced pigs and MRE-derived MS measurements were compared against LV pressure, thickness and circumferential strain. MATERIALS AND METHODS: Renal-wrapping surgery was performed to induce HTN in eight pigs. LV catheterization (to measure pressure) and cardiac MRI (1.5 Tesla; gradient echo-MRE and tagging) was performed pre-surgery at baseline (Bx), and post-surgery at month 1 (M1) and month 2 (M2). Images were analyzed to estimate LV-MS, thickness, and circumferential strain across the cardiac cycle. The associations between end-diastolic (ED) and end-systolic (ES) MS and (i) mean LV pressure; (ii) ED and ES thickness, respectively; and (iii) circumferential strain were evaluated using Spearman's correlation method. RESULTS: From Bx to M2, mean pressure, MRE-derived stiffness, and thickness increased while circumferential strain decreased significantly (slope test, P ≤ 0.05). Both ED and ES MS had significant positive correlation with (i) mean pressure (ED MS: ρ = 0.56; P = 0.005 and ES MS: ρ = 0.45; P = 0.03); (ii) ED thickness ( ρ = 0.73; P < 0.0001) and ES thickness ( ρ = 0.84; P < 0.0001), respectively; but demonstrated a negative trend with circumferential strain (ED MS: ρ = 0.31 and ES MS: ρ = 0.37). CONCLUSION: This study demonstrated that, in a HTN porcine model, MRE-derived MS increased with increase in pressure and thickness. LEVEL OF EVIDENCE: 1 J. Magn. Reson. Imaging 2017;45:813-820.
PURPOSE: To determine alteration in left ventricular (LV) myocardial stiffness (MS) with hypertension (HTN). Cardiac MR elastography (MRE) was used to estimate MS in HTN induced pigs and MRE-derived MS measurements were compared against LV pressure, thickness and circumferential strain. MATERIALS AND METHODS: Renal-wrapping surgery was performed to induce HTN in eight pigs. LV catheterization (to measure pressure) and cardiac MRI (1.5 Tesla; gradient echo-MRE and tagging) was performed pre-surgery at baseline (Bx), and post-surgery at month 1 (M1) and month 2 (M2). Images were analyzed to estimate LV-MS, thickness, and circumferential strain across the cardiac cycle. The associations between end-diastolic (ED) and end-systolic (ES) MS and (i) mean LV pressure; (ii) ED and ES thickness, respectively; and (iii) circumferential strain were evaluated using Spearman's correlation method. RESULTS: From Bx to M2, mean pressure, MRE-derived stiffness, and thickness increased while circumferential strain decreased significantly (slope test, P ≤ 0.05). Both ED and ES MS had significant positive correlation with (i) mean pressure (ED MS: ρ = 0.56; P = 0.005 and ES MS: ρ = 0.45; P = 0.03); (ii) ED thickness ( ρ = 0.73; P < 0.0001) and ES thickness ( ρ = 0.84; P < 0.0001), respectively; but demonstrated a negative trend with circumferential strain (ED MS: ρ = 0.31 and ES MS: ρ = 0.37). CONCLUSION: This study demonstrated that, in a HTN porcine model, MRE-derived MS increased with increase in pressure and thickness. LEVEL OF EVIDENCE: 1 J. Magn. Reson. Imaging 2017;45:813-820.
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