Literature DB >> 25824100

Efficient isocyanide-less isocyanide-based multicomponent reactions.

Constantinos G Neochoritis1, Silvia Stotani1, Bhupendra Mishra1, Alexander Dömling1.   

Abstract

Isocyanides are the "Jekyll and Hyde" of organic chemistry allowing for extremely interesting transformations that are not only extremely odorous but also noxious. Therefore, an isocyanide-less isocyanide-based multicomponent reaction (IMCR) has been developed, and this protocol is expected to replace many of the old procedures in the future not only in IMCR but in other areas of organic chemistry as well.

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Year:  2015        PMID： 25824100      PMCID： PMC4733495          DOI： 10.1021/acs.orglett.5b00759

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  28 in total

1.  Oral oxytocin antagonists.

Authors:  Alan D Borthwick
Journal:  J Med Chem       Date:  2010-09-23       Impact factor: 7.446

2.  Nucleophilicity parameters for alkyl and aryl isocyanides.

Authors:  Vasily V Tumanov; Alexander A Tishkov; Herbert Mayr
Journal:  Angew Chem Int Ed Engl       Date:  2007       Impact factor: 15.336

3.  Combining on-chip synthesis of a focused combinatorial library with computational target prediction reveals imidazopyridine GPCR ligands.

Authors:  Michael Reutlinger; Tiago Rodrigues; Petra Schneider; Gisbert Schneider
Journal:  Angew Chem Int Ed Engl       Date:  2013-11-26       Impact factor: 15.336

4.  Functionalized 3-amino-imidazo[1,2-a]pyridines: a novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors.

Authors:  Luke R Odell; Mikael T Nilsson; Johan Gising; Olof Lagerlund; Daniel Muthas; Anneli Nordqvist; Anders Karlén; Mats Larhed
Journal:  Bioorg Med Chem Lett       Date:  2009-06-14       Impact factor: 2.823

5.  Aminomethyltetrazoles as potential inhibitors of the γ-aminobutyric acid transporters mGAT1-mGAT4: synthesis and biological evaluation.

Authors:  Eva S Schaffert; Georg Höfner; Klaus T Wanner
Journal:  Bioorg Med Chem       Date:  2011-08-26       Impact factor: 3.641

6.  Multicomponent cascade reactions: sequential [1 + 4] and [2 + 3] cycloadditions for the generation of heterocyclic ring systems.

Authors:  Nicolas M Fédou; Philip J Parsons; Eddy M E Viseux; Alan J Whittle
Journal:  Org Lett       Date:  2005-07-21       Impact factor: 6.005

7.  Efficient assembly of iminodicarboxamides by a "truly" four-component reaction.

Authors:  Kareem Khoury; Mantosh K Sinha; Tadamichi Nagashima; Eberhardt Herdtweck; Alexander Dömling
Journal:  Angew Chem Int Ed Engl       Date:  2012-09-11       Impact factor: 15.336

8.  Passerini reaction-amine deprotection-acyl migration peptide assembly: efficient formal synthesis of cyclotheonamide C.

Authors:  Sophie Faure; Thomas Hjelmgaard; Stéphane P Roche; David J Aitken
Journal:  Org Lett       Date:  2009-03-05       Impact factor: 6.005

9.  Sequence control in polymer chemistry through the Passerini three-component reaction.

Authors:  Susanne C Solleder; Michael A R Meier
Journal:  Angew Chem Int Ed Engl       Date:  2013-12-04       Impact factor: 15.336

10.  Odorless isocyanide chemistry: an integrated microfluidic system for a multistep reaction sequence.

Authors:  Siddharth Sharma; Ram Awatar Maurya; Kyoung-Ik Min; Guan-Young Jeong; Dong-Pyo Kim
Journal:  Angew Chem Int Ed Engl       Date:  2013-06-18       Impact factor: 15.336
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  13 in total

1.  Structure and Reactivity of Glycosyl Isocyanides.

Authors:  Constantinos G Neochoritis; Ehsan Ghonchepour; Maryam Kazemi Miraki; Tryfon Zarganes-Tzitzikas; Katarzyna Kurpiewska; Justyna Kalinowska-Tłuścik; Alexander Dömling
Journal:  European J Org Chem       Date:  2018-11-22

2.  Synthesis of some new triamide derivatives via Ugi five-component reaction in aqueous solution.

Authors:  Ali Asghar Mohammadi; Salman Taheri; Arman Amini; Reza Ahdenov
Journal:  Mol Divers       Date:  2018-06-27       Impact factor: 2.943

3.  Hitting on the move: Targeting intrinsically disordered protein states of the MDM2-p53 interaction.

Authors:  Constantinos G Neochoritis; Jack Atmaj; Aleksandra Twarda-Clapa; Ewa Surmiak; Lukasz Skalniak; Lisa-Maria Köhler; Damian Muszak; Katarzyna Kurpiewska; Justyna Kalinowska-Tłuścik; Barbara Beck; Tad A Holak; Alexander Dömling
Journal:  Eur J Med Chem       Date:  2019-08-06       Impact factor: 6.514

4.  With unprotected amino acids to tetrazolo peptidomimetics.

Authors:  Rudrakshula Madhavachary; Qian Wang; Alexander Dömling
Journal:  Chem Commun (Camb)       Date:  2017-07-27       Impact factor: 6.222

5.  Multicomponent Synthesis and Binding Mode of Imidazo[1,2- a]pyridine-Capped Selective HDAC6 Inhibitors.

Authors:  Marcel K W Mackwitz; Alexandra Hamacher; Jeremy D Osko; Jana Held; Andrea Schöler; David W Christianson; Matthias U Kassack; Finn K Hansen
Journal:  Org Lett       Date:  2018-05-23       Impact factor: 6.005

6.  Screening for Small Molecule Modulators of Trypanosoma brucei Hsp70 Chaperone Activity Based upon Alcyonarian Coral-Derived Natural Products.

Authors:  Sarah K Andreassend; Stephen J Bentley; Gregory L Blatch; Aileen Boshoff; Robert A Keyzers
Journal:  Mar Drugs       Date:  2020-01-27       Impact factor: 5.118

Review 7.  Tetrazoles via Multicomponent Reactions.

Authors:  Constantinos G Neochoritis; Ting Zhao; Alexander Dömling
Journal:  Chem Rev       Date:  2019-02-01       Impact factor: 60.622

Review 8.  The European Lead Factory: A Blueprint for Public-Private Partnerships in Early Drug Discovery.

Authors:  Anna Karawajczyk; Kristina M Orrling; Jon S B de Vlieger; Ton Rijnders; Dimitrios Tzalis
Journal:  Front Med (Lausanne)       Date:  2017-01-19

9.  Ugi Multicomponent Reaction Based Synthesis of Medium-Sized Rings.

Authors:  Eman M M Abdelraheem; Rudrakshula Madhavachary; Arianna Rossetti; Katarzyna Kurpiewska; Justyna Kalinowska-Tłuścik; Shabnam Shaabani; Alexander Dömling
Journal:  Org Lett       Date:  2017-10-30       Impact factor: 6.005

10.  Synthesis of Highly Substituted Imidazole Uracil Containing Molecules via Ugi-4CR and Passerini-3CR.

Authors:  Rudrakshula Madhavachary; Tryfon Zarganes-Tzitzikas; Pravin Patil; Katarzyna Kurpiewska; Justyna Kalinowska-Tłuścik; Alexander Dömling
Journal:  ACS Comb Sci       Date:  2018-02-26       Impact factor: 3.784
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