Literature DB >> 29951885

Synthesis of some new triamide derivatives via Ugi five-component reaction in aqueous solution.

Ali Asghar Mohammadi1, Salman Taheri2, Arman Amini2, Reza Ahdenov2.   

Abstract

Triamide derivatives have been synthesized in good yields in a novel, one-pot, five-component, and efficient process by the reaction of Z-oxazolone, water, primary amines, aldehydes, isocyanides, in the presence of catalytic amount of KAl(SO4)2·12H2O (alum) as a non-toxic, reusable, inexpensive, and easily available reagent via Ugi reaction in aqueous solution.

Entities:  

Keywords:  Aqueous solution; Five-component; Oxazolone; Triamide; Ugi reaction

Mesh：

Substances：

Year:  2018        PMID： 29951885     DOI： 10.1007/s11030-018-9846-z

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  15 in total

1.  Synthesis of novel alpha-amino-N-substituted thioacetimidates.

Authors:  A R Katritzky; M A Button; S Busont
Journal:  J Org Chem       Date:  2001-04-20       Impact factor: 4.354

2.  Multicomponent Reactions with Isocyanides.

Authors: 
Journal:  Angew Chem Int Ed Engl       Date:  2000-09-15       Impact factor: 15.336

Review 3.  "Multi-component reactions : emerging chemistry in drug discovery" 'from xylocain to crixivan'.

Authors:  Christopher Hulme; Vijay Gore
Journal:  Curr Med Chem       Date:  2003-01       Impact factor: 4.530

4.  Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts.

Authors:  Chitalu C Musonda; Dale Taylor; Julie Lehman; Jiri Gut; Philip J Rosenthal; Kelly Chibale
Journal:  Bioorg Med Chem Lett       Date:  2004-08-02       Impact factor: 2.823

Review 5.  Chemistry and biology of multicomponent reactions.

Authors:  Alexander Dömling; Wei Wang; Kan Wang
Journal:  Chem Rev       Date:  2012-03-22       Impact factor: 60.622

6.  Efficient multicomponent reaction synthesis of the schistosomiasis drug praziquantel.

Authors:  Haiping Cao; Haixia Liu; Alexander Dömling
Journal:  Chemistry       Date:  2010-11-02       Impact factor: 5.236

7.  Efficient isocyanide-less isocyanide-based multicomponent reactions.

Authors:  Constantinos G Neochoritis; Silvia Stotani; Bhupendra Mishra; Alexander Dömling
Journal:  Org Lett       Date:  2015-03-31       Impact factor: 6.005

8.  The multiple multicomponent approach to natural product mimics: tubugis, N-substituted anticancer peptides with picomolar activity.

Authors:  Orlando Pando; Sebastian Stark; Annika Denkert; Andrea Porzel; Rainer Preusentanz; Ludger A Wessjohann
Journal:  J Am Chem Soc       Date:  2011-04-29       Impact factor: 15.419

9.  Acid-free, aminoborane-mediated Ugi-type reaction leading to general utilization of secondary amines.

Authors:  Yusuke Tanaka; Tomoaki Hasui; Michinori Suginome
Journal:  Org Lett       Date:  2007-09-22       Impact factor: 6.005

Review 10.  Emerging molecular diversity from the intra-molecular Ugi reaction: iterative efficiency in medicinal chemistry.

Authors:  Christopher Hulme; Justin Dietrich
Journal:  Mol Divers       Date:  2009-02-11       Impact factor: 3.364
View more
  2 in total

Review 1.  The status of isocyanide-based multi-component reactions in Iran (2010-2018).

Authors:  Ronak Afshari; Seyyed Emad Hooshmand; Mohammad Taghi Nazeri; Siamak Javanbakht; Ahmad Shaabani; Reza Mohammadian
Journal:  Mol Divers       Date:  2020-02-18       Impact factor: 2.943

2.  Electro-organic synthesis of tetrahydroimidazo[1,2-a]pyridin-5(1H)-one via a multicomponent reaction.

Authors:  Mohammad Reza Asghariganjeh; Ali Asghar Mohammadi; Elham Tahanpesar; Ayeh Rayatzadeh; Somayeh Makarem
Journal:  Mol Divers       Date:  2020-01-09       Impact factor: 2.943
  2 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.