Literature DB >> 19203293

Passerini reaction-amine deprotection-acyl migration peptide assembly: efficient formal synthesis of cyclotheonamide C.

Sophie Faure1, Thomas Hjelmgaard, Stéphane P Roche, David J Aitken.   

Abstract

A short, convergent, formal total synthesis of cyclotheonamide C is described. The key linear pentapeptide intermediate is assembled at the same time as the elaboration of the alpha-hydroxyhomoarginine (H-hArg) residue via a three-component Passerini reaction-amine deprotection-O,N-acyl migration strategy.

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Year:  2009        PMID： 19203293     DOI： 10.1021/ol900048r

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


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