Literature DB >> 23780803

Odorless isocyanide chemistry: an integrated microfluidic system for a multistep reaction sequence.

Siddharth Sharma1, Ram Awatar Maurya, Kyoung-Ik Min, Guan-Young Jeong, Dong-Pyo Kim.   

Abstract

Can't smell this: An integrated continuous-flow microfluidic setup enables in situ generation, extraction, separation, and reaction of foul-smelling isocyanides with little exposure to the surroundings. Isocyanides were generated by dehydration of the corresponding N-substituted formamides, and several representative isocyanide-based organic reactions were successfully performed. DIPEA = N,N-diisopropylethylamine.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  continuous flow; isocyanides; microreactors; multi-component reactions; organometallics

Year:  2013        PMID： 23780803     DOI： 10.1002/anie.201303213

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  12 in total

1.  Efficient isocyanide-less isocyanide-based multicomponent reactions.

Authors:  Constantinos G Neochoritis; Silvia Stotani; Bhupendra Mishra; Alexander Dömling
Journal:  Org Lett       Date:  2015-03-31       Impact factor: 6.005

2.  Diversity-oriented synthesis of dihydrobenzoxazepinones by coupling the Ugi multicomponent reaction with a Mitsunobu cyclization.

Authors:  Lisa Moni; Luca Banfi; Andrea Basso; Alice Brambilla; Renata Riva
Journal:  Beilstein J Org Chem       Date:  2014-01-17       Impact factor: 2.883

3.  Micro-total envelope system with silicon nanowire separator for safe carcinogenic chemistry.

Authors:  Ajay K Singh; Dong-Hyeon Ko; Niraj K Vishwakarma; Seungwook Jang; Kyoung-Ik Min; Dong-Pyo Kim
Journal:  Nat Commun       Date:  2016-02-26       Impact factor: 14.919

4.  Unsymmetrical difunctionalization of cyclooctadiene under continuous flow conditions: expanding the scope of ring opening metathesis polymerization.

Authors:  Xianwang Shen; Honghong Gong; Yang Zhou; Yucheng Zhao; Jun Lin; Mao Chen
Journal:  Chem Sci       Date:  2018-01-08       Impact factor: 9.825

5.  Integrated CO2 capture-fixation chemistry via interfacial ionic liquid catalyst in laminar gas/liquid flow.

Authors:  Niraj K Vishwakarma; Ajay K Singh; Yoon-Ho Hwang; Dong-Hyeon Ko; Jin-Oh Kim; A Giridhar Babu; Dong-Pyo Kim
Journal:  Nat Commun       Date:  2017-03-06       Impact factor: 14.919

6.  A Mild, Fast, and Scalable Synthesis of Substituted α-Acyloxy Ketones via Multicomponent Reaction Using a Continuous Flow Approach.

Authors:  Carlos Eduardo M Salvador; Carlos Kleber Z Andrade
Journal:  Front Chem       Date:  2019-07-30       Impact factor: 5.221

7.  Novel Selenoureas Based on Cinchona Alkaloid Skeleton: Synthesis and Catalytic Investigations.

Authors:  Mariola Zielińska-Błajet; Joanna Najdek
Journal:  Materials (Basel)       Date:  2021-01-28       Impact factor: 3.623

8.  Efficacy of Selenourea Organocatalysts in Asymmetric Michael Reactions under Standard and Solvent-Free Conditions.

Authors:  Mariola Zielińska-Błajet; Żaneta A Mała; Rafał Kowalczyk
Journal:  Molecules       Date:  2021-12-01       Impact factor: 4.411

9.  Synthesis of α-amino amidines through molecular iodine-catalyzed three-component coupling of isocyanides, aldehydes and amines.

Authors:  Praveen Reddy Adiyala; D Chandrasekhar; Jeevak Sopanrao Kapure; Chada Narsimha Reddy; Ram Awatar Maurya
Journal:  Beilstein J Org Chem       Date:  2014-09-02       Impact factor: 2.883

10.  In situ epoxide generation by dimethyldioxirane oxidation and the use of epichlorohydrin in the flow synthesis of a library of β-amino alcohols.

Authors:  Peter J Cossar; Jennifer R Baker; Nicholas Cain; Adam McCluskey
Journal:  R Soc Open Sci       Date:  2018-04-04       Impact factor: 2.963
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