Martin Heine1, Lizanne Eva van den Akker2, Olaf Verschuren1, Anne Visser-Meily1, Gert Kwakkel3. 1. Brain Center Rudolf Magnus and Center of Excellence for Rehabilitation Medicine, University Medical Center Utrecht and Rehabilitation Center De Hoogstraat, Rembrandtkade 10, 3583 TM, Utrecht, The Netherlands. 2. Department of Rehabilitation Medicine & EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands. 3. Department of Rehabilitation Medicine, MOVE Research Institute Amsterdam, VU University Medical Center, Amsterdam, The Netherlands; Department of Neurorehabilitation, Centre of Rehabilitation and Rheumatology READE, Amsterdam, The Netherlands.
Abstract
BACKGROUND: Peak oxygen uptake (VO2peak) via cardiopulmonary exercise testing is considered the gold standard for testing aerobic capacity in healthy participants and people with various medical conditions. The reliability and responsiveness of cardiopulmonary exercise testing outcomes in persons with MS (PwMS) have not been extensively studied. OBJECTIVE: (1) to investigate the reliability of cardiopulmonary exercise parameters in PwMS; (2) to determine the responsiveness, in terms of the smallest detectable change (SDC), for each parameter. DESIGN: Two repeated measurements of cardiopulmonary exercise outcomes were obtained, with a median time interval of 16 days. METHODS: Thirty-two PwMS suffering from subjective fatigue performed cardiopulmonary exercise tests on a cycle ergometer, to voluntary exhaustion. We calculated the reliability, in terms of the intra-class correlation coefficient (ICC [2,k]; absolute agreement), and the measurement error, in terms of standard error of measurement (SEM) and SDC at individual (SDCindividual) and group level (SDCgroup). RESULTS: The ICC for VO2peak was 0.951, with an SEM of 0.131 L∙min(-1) and an SDCindividual of 0.364 L∙min(-1). When corrected for bodyweight, the ICC of VO2peak was 0.933, with an SEM of 1.7 mL∙kg(-1)∙min(-1) and in an SDCindividual of 4.6 mL∙kg(-1)∙min(-1). LIMITATIONS: Generalization of our study results is restricted to fatigued PwMS with a low to mild level of disability. CONCLUSIONS: At individual level, cardiopulmonary exercise testing can be used reliably to assess physical fitness in terms of VO2peak, but less so to determine significant changes. At group level, VO2peak can be reliably used to determine physical fitness status and establish change over time.
BACKGROUND: Peak oxygen uptake (VO2peak) via cardiopulmonary exercise testing is considered the gold standard for testing aerobic capacity in healthy participants and people with various medical conditions. The reliability and responsiveness of cardiopulmonary exercise testing outcomes in persons with MS (PwMS) have not been extensively studied. OBJECTIVE: (1) to investigate the reliability of cardiopulmonary exercise parameters in PwMS; (2) to determine the responsiveness, in terms of the smallest detectable change (SDC), for each parameter. DESIGN: Two repeated measurements of cardiopulmonary exercise outcomes were obtained, with a median time interval of 16 days. METHODS: Thirty-two PwMS suffering from subjective fatigue performed cardiopulmonary exercise tests on a cycle ergometer, to voluntary exhaustion. We calculated the reliability, in terms of the intra-class correlation coefficient (ICC [2,k]; absolute agreement), and the measurement error, in terms of standard error of measurement (SEM) and SDC at individual (SDCindividual) and group level (SDCgroup). RESULTS: The ICC for VO2peak was 0.951, with an SEM of 0.131 L∙min(-1) and an SDCindividual of 0.364 L∙min(-1). When corrected for bodyweight, the ICC of VO2peak was 0.933, with an SEM of 1.7 mL∙kg(-1)∙min(-1) and in an SDCindividual of 4.6 mL∙kg(-1)∙min(-1). LIMITATIONS: Generalization of our study results is restricted to fatigued PwMS with a low to mild level of disability. CONCLUSIONS: At individual level, cardiopulmonary exercise testing can be used reliably to assess physical fitness in terms of VO2peak, but less so to determine significant changes. At group level, VO2peak can be reliably used to determine physical fitness status and establish change over time.
Authors: Moniek Akkerman; Marco van Brussel; Erik Hulzebos; Luc Vanhees; Paul J M Helders; Tim Takken Journal: J Cardiopulm Rehabil Prev Date: 2010 Nov-Dec Impact factor: 2.081
Authors: Heleen Beckerman; Lyan Jm Blikman; Martin Heine; Arjan Malekzadeh; Charlotte E Teunissen; Johannes Bj Bussmann; Gert Kwakkel; Jetty van Meeteren; Vincent de Groot Journal: Trials Date: 2013-08-12 Impact factor: 2.279
Authors: Jacob B Lindheimer; Thomas Alexander; Wei Qian; Jacquelyn C Klein-Adams; Gudrun Lange; Benjamin H Natelson; Dane B Cook; Helene Z Hill; Michael J Falvo Journal: Physiol Rep Date: 2020-09