Martin Heine1, Olaf Verschuren, Gert Kwakkel. 1. , Brain Center Rudolf Magnus and Center of Excellence for Rehabilitation Medicine, University Medical Center Utrecht and Rehabilitation Center De Hoogstraat, 3583 TM Utrecht, The Netherlands. m.heine@dehoogstraat.nl.
Abstract
OBJECTIVE: To examine the Oxygen Uptake Efficiency Slope (OUES) as an outcome for physical fitness in patients with multiple sclerosis. DESIGN: Cross-sectional study. PATIENTS: A maximal cycling ergometry test was performed by 56 patients with multiple sclerosis. METHODS: The OUES was compared with healthy reference values. Correlation analysis was used to assess the concurrent validity of the OUES and the following commonly used parameters of maximal exercise testing: maximal power output (Wmax) and peak oxygen consumption (VO2peak). The predictive validity of a submaximal OUES, derived using only 50% of the exercise duration (OUES50), and an OUES derived using the full exercise duration (OUES) were determined. RESULTS: The OUES (mean 24.2 (standard deviation; SD 7.2)) was markedly lower than previously reported healthy reference values (mean 46.0 (SD 9.0)). Pearson correlation coefficients ranged from 0.514 (p < 0.01) between the OUES and Wmax and 0.857 for VO2peak (p < 0.01). The predictive validity of OUES50 for OUES was 0.918 (p < 0.01). CONCLUSION: The moderate to high concurrent validity of the OUES with Wmax and VO2peak and high predictive validity of OUES50 for OUES suggest that maximal exercise testing in patients with low to moderate multiple sclerosis is not necessary.
OBJECTIVE: To examine the Oxygen Uptake Efficiency Slope (OUES) as an outcome for physical fitness in patients with multiple sclerosis. DESIGN: Cross-sectional study. PATIENTS: A maximal cycling ergometry test was performed by 56 patients with multiple sclerosis. METHODS: The OUES was compared with healthy reference values. Correlation analysis was used to assess the concurrent validity of the OUES and the following commonly used parameters of maximal exercise testing: maximal power output (Wmax) and peak oxygen consumption (VO2peak). The predictive validity of a submaximal OUES, derived using only 50% of the exercise duration (OUES50), and an OUES derived using the full exercise duration (OUES) were determined. RESULTS: The OUES (mean 24.2 (standard deviation; SD 7.2)) was markedly lower than previously reported healthy reference values (mean 46.0 (SD 9.0)). Pearson correlation coefficients ranged from 0.514 (p < 0.01) between the OUES and Wmax and 0.857 for VO2peak (p < 0.01). The predictive validity of OUES50 for OUES was 0.918 (p < 0.01). CONCLUSION: The moderate to high concurrent validity of the OUES with Wmax and VO2peak and high predictive validity of OUES50 for OUES suggest that maximal exercise testing in patients with low to moderate multiple sclerosis is not necessary.
Authors: Martin Heine; Lizanne Eva van den Akker; Olaf Verschuren; Anne Visser-Meily; Gert Kwakkel Journal: PLoS One Date: 2015-03-19 Impact factor: 3.240
Authors: Augustine J Devasahayam; Arthur R Chaves; Wendy O Lasisi; Marie E Curtis; Katie P Wadden; Liam P Kelly; Ryan Pretty; Alice Chen; Elizabeth M Wallack; Caitlin J Newell; John B Williams; Hannah Kenny; Matthew B Downer; Jason McCarthy; Craig S Moore; Michelle Ploughman Journal: BMC Neurol Date: 2020-01-22 Impact factor: 2.474