Literature DB >> 6089346

DNA markers for nervous system diseases.

J F Gusella, R E Tanzi, M A Anderson, W Hobbs, K Gibbons, R Raschtchian, T C Gilliam, M R Wallace, N S Wexler, P M Conneally.   

Abstract

Recombinant DNA technology has provided a vast new source of DNA markers displaying heritable sequence variation in humans. These markers can be used in family studies to identify the chromosomal location of defective genes causing nervous system disorders. The discovery of a DNA marker linked to Huntington's disease has opened new avenues of research into this disorder and may ultimately permit cloning and characterization of the defective gene.

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Year:  1984        PMID： 6089346     DOI： 10.1126/science.6089346

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  32 in total

1.  Bayesian fine-scale mapping of disease loci, by hidden Markov models.

Authors:  A P Morris; J C Whittaker; D J Balding
Journal:  Am J Hum Genet       Date:  2000-06-01       Impact factor: 11.025

Review 2.  Molecular biology in medicine.

Authors:  B D Young
Journal:  Postgrad Med J       Date:  1992-04       Impact factor: 2.401

3.  Re-identification of familial database records.

Authors:  Bradley Malin
Journal:  AMIA Annu Symp Proc       Date:  2006

4.  Genetics of actin-related sequences in tomato.

Authors:  R Bernatzky; S D Tanksley
Journal:  Theor Appl Genet       Date:  1986-06       Impact factor: 5.699

5.  Studies on DNA markers (D4S10 and D4S43/S127) genetically linked to Huntington's disease in Japanese families.

Authors:  I Kanazawa; I Kondo; J E Ikeda; T Ikeda; Y Shizu; M Yoshida; H Narabayashi; S Kuroda; H Tsunoda; E Mizuta
Journal:  Hum Genet       Date:  1990-08       Impact factor: 4.132

Review 6.  The genetic defect causing Huntington's disease: repeated in other contexts?

Authors:  J F Gusella; F Persichetti; M E MacDonald
Journal:  Mol Med       Date:  1997-04       Impact factor: 6.354

7.  2016 William Allan Award: Human Disease Research: Genetic Cycling and Re-cycling.

Authors:  James F Gusella
Journal:  Am J Hum Genet       Date:  2017-03-02       Impact factor: 11.025

8.  Genetic linkage between Huntington's disease and the DNA polymorphism G8 in South Wales families.

Authors:  P S Harper; S Youngman; M A Anderson; M Sarfarazi; O Quarrell; R Tanzi; D Shaw; P Wallace; P M Conneally; J F Gusella
Journal:  J Med Genet       Date:  1985-12       Impact factor: 6.318

9.  Studies of a DNA marker (G8) genetically linked to Huntington disease in British families.

Authors:  S Youngman; M Sarfarazi; O W Quarrell; P M Conneally; K Gibbons; P S Harper; D J Shaw; R E Tanzi; M R Wallace; J F Gusella
Journal:  Hum Genet       Date:  1986-08       Impact factor: 4.132

10.  Huntington disease mutation in Venezuela: age of onset, haplotype analyses and geographic aggregation.

Authors:  Irene Paradisi; Alba Hernández; Sergio Arias
Journal:  J Hum Genet       Date:  2007-12-22       Impact factor: 3.172
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