Literature DB >> 25337416

Clinical examples of 3D dose distribution reconstruction, based on the actual MLC leaves movement, for dynamic treatment techniques.

Wojciech Osewski1, Lukasz Dolla2, Michał Radwan2, Marta Szlag2, Roman Rutkowski2, Barbara Smolińska2, Krzysztof Slosarek2.   

Abstract

AIM: To present practical examples of our new algorithm for reconstruction of 3D dose distribution, based on the actual MLC leaf movement.
BACKGROUND: DynaLog and RTplan files were used by DDcon software to prepare a new RTplan file for dose distribution reconstruction.
MATERIALS AND METHODS: FOUR DIFFERENT CLINICALLY RELEVANT SCENARIOS WERE USED TO ASSESS THE FEASIBILITY OF THE PROPOSED NEW APPROACH: (1) Reconstruction of whole treatment sessions for prostate cancer; (2) Reconstruction of IMRT verification treatment plan; (3) Dose reconstruction in breast cancer; (4) Reconstruction of interrupted arc and complementary plan for an interrupted VMAT treatment session of prostate cancer. The applied reconstruction method was validated by comparing reconstructed and measured fluence maps. For all statistical analysis, the U Mann-Whitney test was used.
RESULTS: In the first two and the fourth cases, there were no statistically significant differences between the planned and reconstructed dose distribution (p = 0.910, p = 0.975, p = 0.893, respectively). In the third case the differences were statistically significant (p = 0.015). Treatment plan had to be reconstructed.
CONCLUSION: Developed dose distribution reconstruction algorithm presents a very useful QA tool. It provides means for 3D dose distribution verification in patient volume and allows to evaluate the influence of actual MLC leaf motion on the dose distribution.

Entities:  

Keywords:  DICOM; DynaLog; IMRT; RTplan; VMAT

Year:  2014        PMID: 25337416      PMCID: PMC4201771          DOI: 10.1016/j.rpor.2014.04.013

Source DB:  PubMed          Journal:  Rep Pract Oncol Radiother        ISSN: 1507-1367


  11 in total

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