Literature DB >> 24910447

Determinants and implications of mRNA poly(A) tail size--does this protein make my tail look big?

Aimee L Jalkanen1, Stephen J Coleman1, Jeffrey Wilusz2.   

Abstract

While the phenomenon of polyadenylation has been well-studied, the dynamics of poly(A) tail size and its impact on transcript function and cell biology are less well-appreciated. The goal of this review is to encourage readers to view the poly(A) tail as a dynamic, changeable aspect of a transcript rather than a simple static entity that marks the 3' end of an mRNA. This could open up new angles of regulation in the post-transcriptional control of gene expression throughout development, differentiation and cancer.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  Deadenylation; Hyperadenylation; Poly(A) tail; Polyadenylation; mRNA 3′ end processing

Mesh：

Substances：

Year:  2014        PMID： 24910447      PMCID： PMC4163081          DOI： 10.1016/j.semcdb.2014.05.018

Source DB:  PubMed          Journal:  Semin Cell Dev Biol        ISSN： 1084-9521            Impact factor:   7.727


  114 in total

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Journal:  Methods Enzymol       Date:  2008       Impact factor: 1.600

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Authors:  W J Ma; S Chung; H Furneaux
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Review 9.  MicroRNAs: target recognition and regulatory functions.

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  41 in total

Review 1.  Tales of Detailed Poly(A) Tails.

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4.  Star-PAP controlled alternative polyadenylation coupled poly(A) tail length regulates protein expression in hypertrophic heart.

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8.  PERIOD-controlled deadenylation of the timeless transcript in the Drosophila circadian clock.

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Review 9.  Connections between 3' end processing and DNA damage response: Ten years later.

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Journal:  Wiley Interdiscip Rev RNA       Date:  2019-10-28       Impact factor: 9.957

10.  The isolated La-module of LARP1 mediates 3' poly(A) protection and mRNA stabilization, dependent on its intrinsic PAM2 binding to PABPC1.

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