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Literature DB >> 9278474

The Elav-like proteins bind to AU-rich elements and to the poly(A) tail of mRNA.

Abstract

The Elav-like proteins are specific mRNA binding proteins which are required for cellular differentiation. They contain three characteristic RNP2/RNP1-type RNA binding motifs. Previously we have shown that the first and second RNA binding domains bind to AU-rich elements in the 3'-UTR of mRNA. In this paper we show that the Elav-like proteins exhibit poly(A) binding activity. This activity is distinct from poly(A) binding activities that have been previously described. The Elav-like proteins specifically bind to long chain poly(A) tails. We have shown that the third RNA binding domain encompasses this poly(A) binding activity. Using poly(A)-Sepharose beads in a 'sandwich' assay we have shown that the Elav-like proteins can bind simultaneously to the AU-rich element and to the poly(A) tail.

Entities: Chemical

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Year: 1997 PMID： 9278474 PMCID： PMC146929 DOI： 10.1093/nar/25.18.3564

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

30 in total

1. The Elav-like proteins bind to a conserved regulatory element in the 3'-untranslated region of GAP-43 mRNA.

Authors: S Chung; M Eckrich; N Perrone-Bizzozero; D T Kohn; H Furneaux
Journal: J Biol Chem Date: 1997-03-07 Impact factor: 5.157

2. Two different RNA binding activities for the AU-rich element and the poly(A) sequence of the mouse neuronal protein mHuC.

Authors: R Abe; E Sakashita; K Yamamoto; H Sakamoto
Journal: Nucleic Acids Res Date: 1996-12-15 Impact factor: 16.971

3. A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation.

Authors: G Shaw; R Kamen
Journal: Cell Date: 1986-08-29 Impact factor: 41.582

Review 4. mRNA stability in mammalian cells.

Authors: J Ross
Journal: Microbiol Rev Date: 1995-09

5. Sequence-specific interaction of R17 coat protein with its ribonucleic acid binding site.

Authors: J Carey; V Cameron; P L de Haseth; O C Uhlenbeck
Journal: Biochemistry Date: 1983-05-24 Impact factor: 3.162

6. Paraneoplastic encephalomyelitis antigens bind to the AU-rich elements of mRNA.

Authors: J Liu; J Dalmau; A Szabo; M Rosenfeld; J Huber; H Furneaux
Journal: Neurology Date: 1995-03 Impact factor: 9.910

7. Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor.

Authors: P H King; T D Levine; R T Fremeau; J D Keene
Journal: J Neurosci Date: 1994-04 Impact factor: 6.167

8. Hu protein as an early marker of neuronal phenotypic differentiation by subependymal zone cells of the adult songbird forebrain.

Authors: K Barami; K Iversen; H Furneaux; S A Goldman
Journal: J Neurobiol Date: 1995-09

9. A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma.

Authors: K Sakai; M Gofuku; Y Kitagawa; T Ogasawara; G Hirose; M Yamazaki; C S Koh; N Yanagisawa; L Steinman
Journal: Biochem Biophys Res Commun Date: 1994-03-30 Impact factor: 3.575

10. Hu neuronal proteins are expressed in proliferating neurogenic cells.

Authors: M F Marusich; H M Furneaux; P D Henion; J A Weston
Journal: J Neurobiol Date: 1994-02

77 in total

1. Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays.

Authors: S A Tenenbaum; C C Carson; P J Lager; J D Keene
Journal: Proc Natl Acad Sci U S A Date: 2000-12-19 Impact factor: 11.205

2. Embryonic lethal abnormal vision-like RNA-binding proteins regulate neurite outgrowth and tau expression in PC12 cells.

Authors: G E Aranda-Abreu; L Behar; S Chung; H Furneaux; I Ginzburg
Journal: J Neurosci Date: 1999-08-15 Impact factor: 6.167

The Elav-like proteins bind to AU-rich elements and to the poly(A) tail of mRNA.

1. The Elav-like proteins bind to a conserved regulatory element in the 3'-untranslated region of GAP-43 mRNA.

2. Two different RNA binding activities for the AU-rich element and the poly(A) sequence of the mouse neuronal protein mHuC.

3. A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation.

Review 4. mRNA stability in mammalian cells.

5. Sequence-specific interaction of R17 coat protein with its ribonucleic acid binding site.

6. Paraneoplastic encephalomyelitis antigens bind to the AU-rich elements of mRNA.

7. Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3' UTR of mRNA encoding the Id transcriptional repressor.

8. Hu protein as an early marker of neuronal phenotypic differentiation by subependymal zone cells of the adult songbird forebrain.

9. A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma.

10. Hu neuronal proteins are expressed in proliferating neurogenic cells.

1. Identifying mRNA subsets in messenger ribonucleoprotein complexes by using cDNA arrays.

2. Embryonic lethal abnormal vision-like RNA-binding proteins regulate neurite outgrowth and tau expression in PC12 cells.

3. HuR binding to cytoplasmic mRNA is perturbed by heat shock.

4. HuR regulates p21 mRNA stabilization by UV light.

5. Interaction between a poly(A)-specific ribonuclease and the 5' cap influences mRNA deadenylation rates in vitro.

6. The identification of an endonuclease that cleaves within an HuR binding site in mRNA.

7. Protein ligands mediate the CRM1-dependent export of HuR in response to heat shock.

8. Posttranscriptional regulation of gene expression in learning by the neuronal ELAV-like mRNA-stabilizing proteins.

9. Comparative analysis of the plant mRNA-destabilizing element, DST, in mammalian and tobacco cells.

10. Complex formation of the neuron-specific ELAV-like Hu RNA-binding proteins.