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Literature DB >> 24632073

Retroviral strategy to stabilize viral RNA.

Abstract

Unspliced Rous sarcoma virus (RSV) retroviral mRNA undergoes nonsense-mediated RNA decay (NMD) if it has premature termination codons in the gag gene. However, its normal gag termination codon is not subject to NMD despite being 7kb from the 3' poly(A) sequence. An RNA stability element (RSE) has been identified immediately downstream of gag in the RSV genome. It appears to determine the proper context for translation termination and protects the RNA from NMD. The viral stability element may prevent Up-frameshift 1 (Upf1) protein from interacting with the terminating ribosome and release factors to initiate NMD.

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Year: 2014 PMID： 24632073 PMCID： PMC4020189 DOI： 10.1016/j.mib.2014.02.004

Source DB: PubMed Journal: Curr Opin Microbiol ISSN： 1369-5274 Impact factor: 7.934

36 in total

1. Aberrant mRNAs with extended 3' UTRs are substrates for rapid degradation by mRNA surveillance.

Authors: D Muhlrad; R Parker
Journal: RNA Date: 1999-10 Impact factor: 4.942

2. Involvement of SR proteins in mRNA surveillance.

Authors: Zuo Zhang; Adrian R Krainer
Journal: Mol Cell Date: 2004-11-19 Impact factor: 17.970

3. A faux 3'-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay.

Authors: Nadia Amrani; Robin Ganesan; Stephanie Kervestin; David A Mangus; Shubhendu Ghosh; Allan Jacobson
Journal: Nature Date: 2004-11-04 Impact factor: 49.962

4. A 3' UTR sequence stabilizes termination codons in the unspliced RNA of Rous sarcoma virus.

Authors: Jason E Weil; Karen L Beemon
Journal: RNA Date: 2005-11-21 Impact factor: 4.942

5. A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay.

Authors: Isabelle Behm-Ansmant; David Gatfield; Jan Rehwinkel; Valérie Hilgers; Elisa Izaurralde
Journal: EMBO J Date: 2007-02-22 Impact factor: 11.598

6. Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay.

Authors: L E Maquat; X Li
Journal: RNA Date: 2001-03 Impact factor: 4.942

Review 7. The intimate relationships of mRNA decay and translation.

Authors: Bijoyita Roy; Allan Jacobson
Journal: Trends Genet Date: 2013-09-30 Impact factor: 11.639

8. Unspliced Rous sarcoma virus genomic RNAs are translated and subjected to nonsense-mediated mRNA decay before packaging.

Authors: Jason J LeBlanc; Karen L Beemon
Journal: J Virol Date: 2004-05 Impact factor: 5.103

9. Rous sarcoma virus RNA stability requires an open reading frame in the gag gene and sequences downstream of the gag-pol junction.

Authors: G F Barker; K Beemon
Journal: Mol Cell Biol Date: 1994-03 Impact factor: 4.272

10. A large-scale analysis of mRNA polyadenylation of human and mouse genes.

Authors: Bin Tian; Jun Hu; Haibo Zhang; Carol S Lutz
Journal: Nucleic Acids Res Date: 2005-01-12 Impact factor: 16.971

15 in total

1. Nonsense-mediated RNA decay--a switch and dial for regulating gene expression.

Authors: Jenna E Smith; Kristian E Baker
Journal: Bioessays Date: 2015-03-27 Impact factor: 4.345

Review 2. Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use.

Authors: John F Atkins; Gary Loughran; Pramod R Bhatt; Andrew E Firth; Pavel V Baranov
Journal: Nucleic Acids Res Date: 2016-07-19 Impact factor: 16.971

Retroviral strategy to stabilize viral RNA.

1. Aberrant mRNAs with extended 3' UTRs are substrates for rapid degradation by mRNA surveillance.

2. Involvement of SR proteins in mRNA surveillance.

3. A faux 3'-UTR promotes aberrant termination and triggers nonsense-mediated mRNA decay.

4. A 3' UTR sequence stabilizes termination codons in the unspliced RNA of Rous sarcoma virus.

5. A conserved role for cytoplasmic poly(A)-binding protein 1 (PABPC1) in nonsense-mediated mRNA decay.

6. Mammalian heat shock p70 and histone H4 transcripts, which derive from naturally intronless genes, are immune to nonsense-mediated decay.

Review 7. The intimate relationships of mRNA decay and translation.

8. Unspliced Rous sarcoma virus genomic RNAs are translated and subjected to nonsense-mediated mRNA decay before packaging.

9. Rous sarcoma virus RNA stability requires an open reading frame in the gag gene and sequences downstream of the gag-pol junction.

10. A large-scale analysis of mRNA polyadenylation of human and mouse genes.

1. Nonsense-mediated RNA decay--a switch and dial for regulating gene expression.

Review 2. Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use.

Review 3. Viral Evasion and Manipulation of Host RNA Quality Control Pathways.

4. The roles of five conserved lentiviral RNA structures in HIV-1 replication.

Review 5. Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the Story.

Review 6. Targeting of viral RNAs by Upf1-mediated RNA decay pathways.

Review 7. RNA degradation in antiviral immunity and autoimmunity.

Review 8. HTLV-1 Rex Tunes the Cellular Environment Favorable for Viral Replication.

Review 9. Mechanism and regulation of the nonsense-mediated decay pathway.

10. Polypyrimidine tract binding protein 1 protects mRNAs from recognition by the nonsense-mediated mRNA decay pathway.