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Literature DB >> 24626927

Selective methylation of histone H3 variant H3.1 regulates heterochromatin replication.

Yannick Jacob¹, Elisa Bergamin, Mark T A Donoghue, Vanessa Mongeon, Chantal LeBlanc, Philipp Voigt, Charles J Underwood, Joseph S Brunzelle, Scott D Michaels, Danny Reinberg, Jean-François Couture, Robert A Martienssen.

Abstract

Histone variants have been proposed to act as determinants for posttranslational modifications with widespread regulatory functions. We identify a histone-modifying enzyme that selectively methylates the replication-dependent histone H3 variant H3.1. The crystal structure of the SET domain of the histone H3 lysine-27 (H3K27) methyltransferase ARABIDOPSIS TRITHORAX-RELATED PROTEIN 5 (ATXR5) in complex with a H3.1 peptide shows that ATXR5 contains a bipartite catalytic domain that specifically "reads" alanine-31 of H3.1. Variation at position 31 between H3.1 and replication-independent H3.3 is conserved in plants and animals, and threonine-31 in H3.3 is responsible for inhibiting the activity of ATXR5 and its paralog, ATXR6. Our results suggest a simple model for the mitotic inheritance of the heterochromatic mark H3K27me1 and the protection of H3.3-enriched genes against heterochromatization during DNA replication.

Entities: Chemical

Mesh：

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Year: 2014 PMID： 24626927 PMCID： PMC4049228 DOI： 10.1126/science.1248357

Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728

40 in total

1. Increased frequency of homologous recombination and T-DNA integration in Arabidopsis CAF-1 mutants.

Authors: Masaki Endo; Yuichi Ishikawa; Keishi Osakabe; Shigeki Nakayama; Hidetaka Kaya; Takashi Araki; Kei-ichi Shibahara; Kiyomi Abe; Hiroaki Ichikawa; Lisa Valentine; Barbara Hohn; Seiichi Toki
Journal: EMBO J Date: 2006-11-16 Impact factor: 11.598

2. Mass spectrometry analysis of Arabidopsis histone H3 reveals distinct combinations of post-translational modifications.

Authors: Lianna Johnson; Sahana Mollah; Benjamin A Garcia; Tara L Muratore; Jeffrey Shabanowitz; Donald F Hunt; Steven E Jacobsen
Journal: Nucleic Acids Res Date: 2004-12-14 Impact factor: 16.971

3. Two cell-cycle regulated SET-domain proteins interact with proliferating cell nuclear antigen (PCNA) in Arabidopsis.

Authors: Cécile Raynaud; Rosangela Sozzani; Nathalie Glab; Séverine Domenichini; Claudette Perennes; Rino Cella; Eva Kondorosi; Catherine Bergounioux
Journal: Plant J Date: 2006-06-12 Impact factor: 6.417

4. Chromatin assembly factor 1 ensures the stable maintenance of silent chromatin states in Arabidopsis.

Authors: Tatsuya Ono; Hidetaka Kaya; Shin Takeda; Mitsutomo Abe; Yuya Ogawa; Masaomi Kato; Tetsuji Kakutani; Ortrun Mittelsten Scheid; Takashi Araki; Kei-ichi Shibahara
Journal: Genes Cells Date: 2006-02 Impact factor: 1.891

Review 5. Marking histone H3 variants: how, when and why?

Authors: Alejandra Loyola; Geneviève Almouzni
Journal: Trends Biochem Sci Date: 2007-08-30 Impact factor: 13.807

6. Purification and characterization of CAF-I, a human cell factor required for chromatin assembly during DNA replication in vitro.

Authors: S Smith; B Stillman
Journal: Cell Date: 1989-07-14 Impact factor: 41.582

7. The chromatin assembly factor subunit FASCIATA1 is involved in homologous recombination in plants.

Authors: Angela Kirik; Ales Pecinka; Edelgard Wendeler; Bernd Reiss
Journal: Plant Cell Date: 2006-09-15 Impact factor: 11.277

8. Functional genomic analysis of CAF-1 mutants in Arabidopsis thaliana.

Authors: Nicole Schönrock; Vivien Exner; Aline Probst; Wilhelm Gruissem; Lars Hennig
Journal: J Biol Chem Date: 2006-02-01 Impact factor: 5.157

9. BRU1, a novel link between responses to DNA damage and epigenetic gene silencing in Arabidopsis.

Authors: Shin Takeda; Zerihun Tadele; Ingo Hofmann; Aline V Probst; Karel J Angelis; Hidetaka Kaya; Takashi Araki; Tesfaye Mengiste; Ortrun Mittelsten Scheid; Kei-ichi Shibahara; Dierk Scheel; Jerzy Paszkowski
Journal: Genes Dev Date: 2004-04-01 Impact factor: 11.361

10. The Histone Deacetylase Complex 1 Protein of Arabidopsis Has the Capacity to Interact with Multiple Proteins Including Histone 3-Binding Proteins and Histone 1 Variants.

Authors: Giorgio Perrella; Craig Carr; Maria A Asensi-Fabado; Naomi A Donald; Katalin Páldi; Matthew A Hannah; Anna Amtmann
Journal: Plant Physiol Date: 2016-03-07 Impact factor: 8.340

Selective methylation of histone H3 variant H3.1 regulates heterochromatin replication.

1. Increased frequency of homologous recombination and T-DNA integration in Arabidopsis CAF-1 mutants.

2. Mass spectrometry analysis of Arabidopsis histone H3 reveals distinct combinations of post-translational modifications.

3. Two cell-cycle regulated SET-domain proteins interact with proliferating cell nuclear antigen (PCNA) in Arabidopsis.

4. Chromatin assembly factor 1 ensures the stable maintenance of silent chromatin states in Arabidopsis.

Review 5. Marking histone H3 variants: how, when and why?

6. Purification and characterization of CAF-I, a human cell factor required for chromatin assembly during DNA replication in vitro.

7. The chromatin assembly factor subunit FASCIATA1 is involved in homologous recombination in plants.

8. Functional genomic analysis of CAF-1 mutants in Arabidopsis thaliana.

9. BRU1, a novel link between responses to DNA damage and epigenetic gene silencing in Arabidopsis.

10. Asymmetrically modified nucleosomes.

Review 1. Histone variants on the move: substrates for chromatin dynamics.

2. Functional Redundancy of Variant and Canonical Histone H3 Lysine 9 Modification in Drosophila.

Review 3. The roles of histone variants in fine-tuning chromatin organization and function.

Review 4. Genetic and epigenetic variation of transposable elements in Arabidopsis.

Review 5. Chromatin and Epigenetics at the Forefront: Finding Clues among Peaks.

6. Histone H3 Dynamics Reveal Domains with Distinct Proliferation Potential in the Arabidopsis Root.

Review 7. Heterochromatin and DNA damage repair: Use different histone variants and relax.

Review 8. Plant epigenetic mechanisms: role in abiotic stress and their generational heritability.

Review 9. Trans-Homolog Interactions Facilitating Paramutation in Maize.

10. The Histone Deacetylase Complex 1 Protein of Arabidopsis Has the Capacity to Interact with Multiple Proteins Including Histone 3-Binding Proteins and Histone 1 Variants.