Literature DB >> 2451760

Evidence for a complex structure of neutralization antigenic site I of poliovirus type 1 Mahoney.

K Wiegers1, H Uhlig, R Dernick.   

Abstract

We have selected neutralization escape mutants by using a monoclonal antibody (nt-MAb) against a sequential epitope between amino acids 93 through 104 (neutralization antigenic site I) of poliovirus type 1 Mahoney. The majority of mutants were also resistant against five strain-specific nt-MAbs which recognized conformation-dependent epitopes, suggesting that the neutralization antigenic site I must be involved in the formation of such epitopes. An analysis of all mutants by the binding of nt-MAbs and by isoelectric focusing of VP1 allowed discrimination of five classes of mutants. Sequence analysis of mutant RNAs revealed point mutations and deletions in the antibody-binding site.

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Year:  1988        PMID： 2451760      PMCID： PMC253247     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  20 in total

1.  Isoelectric focusing and 2D-analysis of poliovirus proteins.

Authors:  A Hamann; K J Wiegers; R Drzeniek
Journal:  Virology       Date:  1977-05-01       Impact factor: 3.616

2.  Characteristics of the microplate method of enzyme-linked immunosorbent assay for the detection of plant viruses.

Authors:  M F Clark; A N Adams
Journal:  J Gen Virol       Date:  1977-03       Impact factor: 3.891

3.  Characterization of type 1 poliovirus by electrophoretic analysis.

Authors:  B Mandel
Journal:  Virology       Date:  1971-06       Impact factor: 3.616

4.  Bivalent attachment of antibody onto poliovirus leads to conformational alteration and neutralization.

Authors:  E A Emini; P Ostapchuk; E Wimmer
Journal:  J Virol       Date:  1983-11       Impact factor: 5.103

5.  Location and primary structure of a major antigenic site for poliovirus neutralization.

Authors:  P D Minor; G C Schild; J Bootman; D M Evans; M Ferguson; P Reeve; M Spitz; G Stanway; A J Cann; R Hauptmann; L D Clarke; R C Mountford; J W Almond
Journal:  Nature       Date:  1983-02-24       Impact factor: 49.962

6.  A simple quantitative protein A micro-immunoprecipitation method; assay of antibodies to the N and H antigens of poliovirus.

Authors:  R Vrijsen; B Rombaut; A Boeyé
Journal:  J Immunol Methods       Date:  1983-04-29       Impact factor: 2.303

7.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

8.  Complete nucleotide sequence of the attenuated poliovirus Sabin 1 strain genome.

Authors:  A Nomoto; T Omata; H Toyoda; S Kuge; H Horie; Y Kataoka; Y Genba; Y Nakano; N Imura
Journal:  Proc Natl Acad Sci U S A       Date:  1982-10       Impact factor: 11.205

9.  Localization of a poliovirus type 1 neutralization epitope in viral capsid polypeptide VP1.

Authors:  S van der Werf; C Wychowski; P Bruneau; B Blondel; R Crainic; F Horodniceanu; M Girard
Journal:  Proc Natl Acad Sci U S A       Date:  1983-08       Impact factor: 11.205

10.  Binding site of neutralizing monoclonal antibodies obtained after in vivo priming with purified VP1 of poliovirus type 1 is located between amino acid residues 93 and 104 of VP1.

Authors:  K J Wiegers; R Dernick
Journal:  Virology       Date:  1987-03       Impact factor: 3.616
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  10 in total

1.  Molecular basis of antigenic structures of poliovirus: implications for their evolution during morphogenesis.

Authors:  K Wiegers; R Dernick
Journal:  J Virol       Date:  1992-07       Impact factor: 5.103

2.  Molecular basis for linkage of a continuous and discontinuous neutralization epitope on the structural polypeptide VP2 of poliovirus type 1.

Authors:  K J Wiegers; K Wetz; R Dernick
Journal:  J Virol       Date:  1990-03       Impact factor: 5.103

3.  Calibration of multiple poliovirus molecular clocks covering an extended evolutionary range.

Authors:  Jaume Jorba; Ray Campagnoli; Lina De; Olen Kew
Journal:  J Virol       Date:  2008-02-20       Impact factor: 5.103

4.  Analysis of neutralizing antigenic sites on the surface of type A12 foot-and-mouth disease virus.

Authors:  B Baxt; V Vakharia; D M Moore; A J Franke; D O Morgan
Journal:  J Virol       Date:  1989-05       Impact factor: 5.103

5.  Intratypic recombination among lineages of type 1 vaccine-derived poliovirus emerging during chronic infection of an immunodeficient patient.

Authors:  Chen-Fu Yang; Hour-Young Chen; Jaume Jorba; Hui-Chih Sun; Su-Ju Yang; Hsiang-Chi Lee; Yhu-Chering Huang; Tzou-Yien Lin; Pei-Jer Chen; Hiroyuki Shimizu; Yorihiro Nishimura; Andi Utama; Mark Pallansch; Tatsuo Miyamura; Olen Kew; Jyh-Yuan Yang
Journal:  J Virol       Date:  2005-10       Impact factor: 5.103

6.  Emergence and localized circulation of a vaccine-derived poliovirus in an isolated mountain community in Guangxi, China.

Authors:  Dongmei Yan; Li Li; Shuangli Zhu; Yong Zhang; Junjing An; Dongyan Wang; Ning Wen; Jaume Jorba; Wei Liu; Ge Zhong; Lin Huang; Olen Kew; Xiaofeng Liang; Wenbo Xu
Journal:  J Clin Microbiol       Date:  2010-07-14       Impact factor: 5.948

7.  Monoclonal anti-idiotypes induce neutralizing antibodies to enterovirus 70 conformational epitopes.

Authors:  J A Wiley; J Hamel; B R Brodeur
Journal:  J Virol       Date:  1992-10       Impact factor: 5.103

8.  Identification of T-helper epitopes in the VP1 capsid protein of poliovirus.

Authors:  M Kutubuddin; J Simons; M Chow
Journal:  J Virol       Date:  1992-05       Impact factor: 5.103

9.  Long-term circulation of vaccine-derived poliovirus that causes paralytic disease.

Authors:  Elena A Cherkasova; Ekaterina A Korotkova; Maria L Yakovenko; Olga E Ivanova; Tatyana P Eremeeva; Konstantin M Chumakov; Vadim I Agol
Journal:  J Virol       Date:  2002-07       Impact factor: 5.103

10.  Postabsorption neutralization of poliovirus.

Authors:  R Vrijsen; A Mosser; A Boeyé
Journal:  J Virol       Date:  1993-06       Impact factor: 5.103
  10 in total

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