Literature DB >> 6186919

Location and primary structure of a major antigenic site for poliovirus neutralization.

P D Minor, G C Schild, J Bootman, D M Evans, M Ferguson, P Reeve, M Spitz, G Stanway, A J Cann, R Hauptmann, L D Clarke, R C Mountford, J W Almond.   

Abstract

We have determined a major antigenic site for virus neutralization on the capsid protein VP1 of poliovirus type 3. Antigenic mutant viruses selected for resistance to individual monoclonal antibodies had point mutations concentrated in a region 277-294 bases downstream from the start of the region of viral RNA coding for VP1. These findings provide the basis for an improved understanding of the molecular basis of virus neutralization.

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Year:  1983        PMID： 6186919     DOI： 10.1038/301674a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  70 in total

1.  Molecular basis of antigenic structures of poliovirus: implications for their evolution during morphogenesis.

Authors:  K Wiegers; R Dernick
Journal:  J Virol       Date:  1992-07       Impact factor: 5.103

2.  Molecular basis for linkage of a continuous and discontinuous neutralization epitope on the structural polypeptide VP2 of poliovirus type 1.

Authors:  K J Wiegers; K Wetz; R Dernick
Journal:  J Virol       Date:  1990-03       Impact factor: 5.103

3.  Identification of neutralizing antigenic sites on VP1 and VP2 of type A5 foot-and-mouth disease virus, defined by neutralization-resistant variants.

Authors:  J C Saiz; M J Gonzalez; M V Borca; F Sobrino; D M Moore
Journal:  J Virol       Date:  1991-05       Impact factor: 5.103

4.  Application of PCR-based methods to assess the infectivity of enteric viruses in environmental samples.

Authors:  Roberto A Rodríguez; Ian L Pepper; Charles P Gerba
Journal:  Appl Environ Microbiol       Date:  2008-11-14       Impact factor: 4.792

5.  Mutations conferring resistance to neutralization with monoclonal antibodies in type 1 poliovirus can be located outside or inside the antibody-binding site.

Authors:  B Blondel; R Crainic; O Fichot; G Dufraisse; A Candrea; D Diamond; M Girard; F Horaud
Journal:  J Virol       Date:  1986-01       Impact factor: 5.103

6.  Monoclonal antibodies: a potentially powerful tool in the diagnosis and treatment of infectious diseases.

Authors:  G Spira; R R Pollock; A Bargellesi; M D Scharff
Journal:  Eur J Clin Microbiol       Date:  1985-06       Impact factor: 3.267

7.  Different virus-precipitating activities of neutralizing monoclonal antibodies that recognize distinct sites of poliovirus particles.

Authors:  K Taniguchi; S Urasawa
Journal:  Arch Virol       Date:  1987       Impact factor: 2.574

8.  Location of the major antigenic sites involved in rotavirus serotype-specific neutralization.

Authors:  M L Dyall-Smith; I Lazdins; G W Tregear; I H Holmes
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205

9.  Very high frequency of reversion to guanidine resistance in clonal pools of guanidine-dependent type 1 poliovirus.

Authors:  J C de la Torre; E Wimmer; J J Holland
Journal:  J Virol       Date:  1990-02       Impact factor: 5.103

10.  High nucleotide substitution error frequencies in clonal pools of vesicular stomatitis virus.

Authors:  D A Steinhauer; J C de la Torre; J J Holland
Journal:  J Virol       Date:  1989-05       Impact factor: 5.103
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