Literature DB >> 24477767

Towards a facile and convenient synthesis of highly functionalized indole derivatives based on multi-component reactions.

Constantinos G Neochoritis1, Alexander Dömling.   

Abstract

A library of potentially bioactive compounds through the novel 1H-indole-methyl-isocyanide and MCRs has been described. A flexible and efficient synthesis affording great complexity and diversity is achieved with moderate to good yields with no need for protection and deprotection steps.

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Year:  2014        PMID： 24477767      PMCID： PMC4015188          DOI： 10.1039/c4ob00166d

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  12 in total

Review 1.  Chemistry and biology of multicomponent reactions.

Authors:  Alexander Dömling; Wei Wang; Kan Wang
Journal:  Chem Rev       Date:  2012-03-22       Impact factor: 60.622

2.  Concise construction of novel bridged bicyclic lactams by sequenced Ugi/RCM/Heck reactions.

Authors:  Timothy P Ribelin; Andrew S Judd; Irini Akritopoulou-Zanze; Rodger F Henry; Jeffrey L Cross; David N Whittern; Stevan W Djuric
Journal:  Org Lett       Date:  2007-11-01       Impact factor: 6.005

3.  Polycyclic indole alkaloid-type compounds by MCR.

Authors:  Wei Wang; Eberhardt Herdtweck; Alexander Dömling
Journal:  Chem Commun (Camb)       Date:  2009-12-11       Impact factor: 6.222

4.  Efficient and diverse synthesis of indole derivatives.

Authors:  Haixia Liu; Alexander Dömling
Journal:  J Org Chem       Date:  2009-09-04       Impact factor: 4.354

5.  Catalytic functionalization of indoles in a new dimension.

Authors:  Marco Bandini; Astrid Eichholzer
Journal:  Angew Chem Int Ed Engl       Date:  2009       Impact factor: 15.336

6.  Rapid and selective access to three distinct sets of indole-based heterocycles from a single set of Ugi-adducts under microwave heating.

Authors:  Lei Zhang; Fei Zhao; Mingyue Zheng; Yun Zhai; Hong Liu
Journal:  Chem Commun (Camb)       Date:  2013-04-11       Impact factor: 6.222

7.  Indole synthesis: a review and proposed classification.

Authors:  Douglass F Taber; Pavan K Tirunahari
Journal:  Tetrahedron       Date:  2011-09-23       Impact factor: 2.457

8.  Efficient assembly of iminodicarboxamides by a "truly" four-component reaction.

Authors:  Kareem Khoury; Mantosh K Sinha; Tadamichi Nagashima; Eberhardt Herdtweck; Alexander Dömling
Journal:  Angew Chem Int Ed Engl       Date:  2012-09-11       Impact factor: 15.336

9.  A four component coupling strategy for the synthesis of D-phenylglycinamide-derived non-covalent factor Xa inhibitors.

Authors:  Scott M Sheehan; John J Masters; Michael R Wiley; Stephen C Young; John W Liebeschuetz; Stuart D Jones; Christopher W Murray; Jeffrey B Franciskovich; David B Engel; Wayne W Weber; Jothirajah Marimuthu; Jeffrey A Kyle; Jeffrey K Smallwood; Mark W Farmen; Gerald F Smith
Journal:  Bioorg Med Chem Lett       Date:  2003-07-21       Impact factor: 2.823

10.  Switching the regioselectivity via indium(III) and gold(I) catalysis: a post-Ugi intramolecular hydroarylation to azepino- and azocino-[c,d]indolones.

Authors:  Amit Kumar; Zhenghua Li; Sunil K Sharma; Virinder S Parmar; Erik V Van der Eycken
Journal:  Chem Commun (Camb)       Date:  2013-08-04       Impact factor: 6.222
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  5 in total

Review 1.  Tetrazoles via Multicomponent Reactions.

Authors:  Constantinos G Neochoritis; Ting Zhao; Alexander Dömling
Journal:  Chem Rev       Date:  2019-02-01       Impact factor: 60.622

2.  Application of Silver Nanoparticles in the Multicomponent Reaction Domain: A Combined Catalytic Reduction Methodology to Efficiently Access Potential Hypertension or Inflammation Inhibitors.

Authors:  Domna Iordanidou; Tryfon Zarganes-Tzitzikas; Constantinos G Neochoritis; Alexander Dömling; Ioannis N Lykakis
Journal:  ACS Omega       Date:  2018-11-27

3.  Supported Gold Nanoparticle-Catalyzed Selective Reduction of Multifunctional, Aromatic Nitro Precursors into Amines and Synthesis of 3,4-Dihydroquinoxalin-2-Ones.

Authors:  Domna Iordanidou; Michael G Kallitsakis; Marina A Tzani; Dimitris I Ioannou; Tryfon Zarganes-Tzitzikas; Constantinos G Neochoritis; Alexander Dömling; Michael A Terzidis; Ioannis N Lykakis
Journal:  Molecules       Date:  2022-07-08       Impact factor: 4.927

4.  Experimental and theoretical studies of new Co(III) complexes of hydrazide derivatives proposed as multi-target inhibitors of SARS-CoV-2.

Authors:  Sakineh Parvarinezhad; Mehdi Salehi; Maciej Kubicki; Rahimeh Eshaghi Malekshah
Journal:  Appl Organomet Chem       Date:  2022-08-08       Impact factor: 4.072

5.  Design and synthesis of heterocyclic azole based bioactive compounds: Molecular structures, quantum simulation, and mechanistic studies through docking as multi-target inhibitors of SARS-CoV-2 and cytotoxicity.

Authors:  Jebiti Haribabu; Vasavi Garisetti; Rahime Eshaghi Malekshah; Swaminathan Srividya; Dasararaju Gayathri; Nattamai Bhuvanesh; Ramalinga Viswanathan Mangalaraja; Cesar Echeverria; Ramasamy Karvembu
Journal:  J Mol Struct       Date:  2021-10-21       Impact factor: 3.196
  5 in total

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