Literature DB >> 20087515

Polycyclic indole alkaloid-type compounds by MCR.

Wei Wang1, Eberhardt Herdtweck, Alexander Dömling.   

Abstract

Polycyclic indole moieties are often part of bioactive natural or synthetic products, however traditionally have to be synthesized over several steps involving time consuming sequential multi-step syntheses. We herein communicate an efficient and flexible 2-step procedure to complex multicyclic indole alkaloid-type compounds involving Ugi MCR and Pictet-Spengler reaction.

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Year:  2009        PMID： 20087515     DOI： 10.1039/b917660h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  11 in total

Review 1.  Chemistry and biology of multicomponent reactions.

Authors:  Alexander Dömling; Wei Wang; Kan Wang
Journal:  Chem Rev       Date:  2012-03-22       Impact factor: 60.622

2.  Towards a facile and convenient synthesis of highly functionalized indole derivatives based on multi-component reactions.

Authors:  Constantinos G Neochoritis; Alexander Dömling
Journal:  Org Biomol Chem       Date:  2014-03-14       Impact factor: 3.876

3.  Polycyclic compounds by Ugi-Pictet-Spengler sequence.

Authors:  Wei Wang; Sarah Ollio; Eberhardt Herdtweck; Alexander Dömling
Journal:  J Org Chem       Date:  2010-12-29       Impact factor: 4.354

Review 4.  Tetrazoles via Multicomponent Reactions.

Authors:  Constantinos G Neochoritis; Ting Zhao; Alexander Dömling
Journal:  Chem Rev       Date:  2019-02-01       Impact factor: 60.622

5.  Various cyclization scaffolds by a truly Ugi 4-CR.

Authors:  Mantosh K Sinha; Kareem Khoury; Eberhardt Herdtweck; Alexander Dömling
Journal:  Org Biomol Chem       Date:  2013-06-13       Impact factor: 3.876

6.  Tricycles by a new Ugi variation and Pictet-Spengler reaction in one pot.

Authors:  Mantosh K Sinha; Kareem Khoury; Eberhardt Herdtweck; Alexander Dömling
Journal:  Chemistry       Date:  2013-05-06       Impact factor: 5.236

Review 7.  Recent advances in the development of polycyclic skeletons via Ugi reaction cascades.

Authors:  Jie Lei; Jiang-Ping Meng; Dian-Yong Tang; Brendan Frett; Zhong-Zhu Chen; Zhi-Gang Xu
Journal:  Mol Divers       Date:  2018-01-16       Impact factor: 2.943

8.  Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities.

Authors:  Yijun Huang; Siglinde Wolf; Barbara Beck; Lisa-Maria Köhler; Kareem Khoury; Grzegorz M Popowicz; Sayed K Goda; Marion Subklewe; Aleksandra Twarda; Tad A Holak; Alexander Dömling
Journal:  ACS Chem Biol       Date:  2014-01-17       Impact factor: 5.100

9.  Stereoselective Synthesis of Functionalized Bicyclic Scaffolds by Passerini 3-Center-2-Component Reactions of Cyclic Ketoacids.

Authors:  Răzvan C Cioc; Verónica Estévez; Daan J van der Niet; Christophe M L Vande Velde; Nikolaus G Turrini; Mélanie Hall; Kurt Faber; Eelco Ruijter; Romano V A Orru
Journal:  European J Org Chem       Date:  2017-03-08

10.  Diverse Isoquinoline Scaffolds by Ugi/Pomeranz-Fritsch and Ugi/Schlittler-Müller Reactions.

Authors:  Yuanze Wang; Pravin Patil; Katarzyna Kurpiewska; Justyna Kalinowska-Tluscik; Alexander Dömling
Journal:  Org Lett       Date:  2019-04-29       Impact factor: 6.005
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