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Literature DB >> 22435608

Chemistry and biology of multicomponent reactions.

Alexander Dömling¹, Wei Wang, Kan Wang.

Abstract

Mesh：

Substances：

Year: 2012 PMID： 22435608 PMCID： PMC3712876 DOI： 10.1021/cr100233r

Source DB: PubMed Journal: Chem Rev ISSN： 0009-2665 Impact factor: 60.622

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241 in total

Review 1. Targeting protein-protein interactions for cancer therapy.

Authors: David C Fry; Lyubomir T Vassilev
Journal: J Mol Med (Berl) Date: 2005-11-11 Impact factor: 4.599

2. Multicomponent synthesis of 2-imidazolines.

Authors: Robin S Bon; Bart van Vliet; Nanda E Sprenkels; Rob F Schmitz; Frans J J de Kanter; Christian V Stevens; Marcel Swart; F Matthias Bickelhaupt; Marinus B Groen; Romano V A Orru
Journal: J Org Chem Date: 2005-04-29 Impact factor: 4.354

3. The structure of glycogen phosphorylase b with an alkyldihydropyridine-dicarboxylic acid compound, a novel and potent inhibitor.

Authors: S E Zographos; N G Oikonomakos; K E Tsitsanou; D D Leonidas; E D Chrysina; V T Skamnaki; H Bischoff; S Goldmann; K A Watson; L N Johnson
Journal: Structure Date: 1997-11-15 Impact factor: 5.006

4. Discovery of small molecule human C5a receptor antagonists.

Authors: Hitesh J Sanganee; Andrew Baxter; Simon Barber; Alastair J H Brown; Denise Grice; Fraser Hunt; Sarah King; David Laughton; Garry Pairaudeau; Bob Thong; Richard Weaver; John Unitt
Journal: Bioorg Med Chem Lett Date: 2008-12-31 Impact factor: 2.823

5. A four component coupling strategy for the synthesis of D-phenylglycinamide-derived non-covalent factor Xa inhibitors.

Authors: Scott M Sheehan; John J Masters; Michael R Wiley; Stephen C Young; John W Liebeschuetz; Stuart D Jones; Christopher W Murray; Jeffrey B Franciskovich; David B Engel; Wayne W Weber; Jothirajah Marimuthu; Jeffrey A Kyle; Jeffrey K Smallwood; Mark W Farmen; Gerald F Smith
Journal: Bioorg Med Chem Lett Date: 2003-07-21 Impact factor: 2.823

6. Application of multicomponent reactions to antimalarial drug discovery. Part 3: discovery of aminoxazole 4-aminoquinolines with potent antiplasmodial activity in vitro.

Authors: Chitalu C Musonda; Susan Little; Vanessa Yardley; Kelly Chibale
Journal: Bioorg Med Chem Lett Date: 2007-06-27 Impact factor: 2.823

7. A resource-efficient and highly flexible procedure for a three-component synthesis of 2-imidazolines.

Authors: Niels Elders; Rob F Schmitz; Frans J J de Kanter; Eelco Ruijter; Marinus B Groen; Romano V A Orru
Journal: J Org Chem Date: 2007-07-12 Impact factor: 4.354

8. One-pot synthesis of diverse 4-di(tri)fluoromethyl-3-cyanopyridine-2(1H)-thiones and their utilities in the cascade synthesis of annulated heterocycles.

Authors: Lyudmila A Rodinovskaya; Anatoliy M Shestopalov; Anna V Gromova; Alexander A Shestopalov
Journal: J Comb Chem Date: 2008-02-13

9. Small-molecule screen identifies inhibitors of a human intestinal calcium-activated chloride channel.

Authors: Ricardo De La Fuente; Wan Namkung; Aaron Mills; A S Verkman
Journal: Mol Pharmacol Date: 2007-12-14 Impact factor: 4.436

Review 10. Emerging molecular diversity from the intra-molecular Ugi reaction: iterative efficiency in medicinal chemistry.

Authors: Christopher Hulme; Justin Dietrich
Journal: Mol Divers Date: 2009-02-11 Impact factor: 3.364

204 in total

1. REGIOSELECTIVE MULTICOMPONENT DOMINO REACTIONS PROVIDING RAPID AND EFFICIENT ROUTES TO FUSED ACRIDINES.

Authors: Jin-Peng Zhang; Wei Fan; Jie Ding; Bo Jiang; Shu-Jiang Tu; Guigen Li
Journal: Heterocycles Date: 2013-12-17 Impact factor: 0.831

Review 2. Focusing on shared subpockets - new developments in fragment-based drug discovery.

Authors: Eman M M Abdelraheem; Carlos J Camacho; Alexander Dömling
Journal: Expert Opin Drug Discov Date: 2015-08-21 Impact factor: 6.098

3. Construction of functionalized tricyclic dihydropyrazino-quinazolinedione chemotypes via an Ugi/N-acyliminium ion cyclization cascade.

Authors: Steven Gunawan; Christopher Hulme
Journal: Tetrahedron Lett Date: 2013-08-14 Impact factor: 2.415

4. An efficient three-component synthesis of highly functionalized tetrahydroacenaphtho[1,2-b]indolone derivatives catalyzed by L-proline.

Authors: Juan-Juan Zhang; Xian Feng; Xue-Cheng Liu; Zhi-Bin Huang; Da-Qing Shi
Journal: Mol Divers Date: 2014-08-24 Impact factor: 2.943