| Literature DB >> 17973488 |
Timothy P Ribelin1, Andrew S Judd, Irini Akritopoulou-Zanze, Rodger F Henry, Jeffrey L Cross, David N Whittern, Stevan W Djuric.
Abstract
Herein we report a concise protocol for the diastereoselective synthesis of novel bridged bicyclic lactams from commercially available components by the sequence of Ugi, ring-closing metathesis (RCM), and Heck reactions. X-ray diffraction studies revealed that the bicyclic products contain varying degrees of pyramidalization of the bridgehead nitrogen atom.Entities:
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Year: 2007 PMID： 17973488 DOI： 10.1021/ol7023373
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005