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Literature DB >> 19663394

Efficient and diverse synthesis of indole derivatives.

Abstract

A convergent 2-step procedure toward an array of indole derivatives involving an Ugi reaction and a Pictet-Spengler reaction is described. The reactions are versatile regarding different starting materials. Hexacyclic 24 can be produced with unprecedented complexity.

Entities: Chemical

Mesh：

Substances：

Year: 2009 PMID： 19663394 DOI： 10.1021/jo900986z

Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354

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Cited

10 in total

Review 1. Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.

Authors: Roland E Dolle; Bertrand Le Bourdonnec; Karin Worm; Guillermo A Morales; Craig J Thomas; Wei Zhang
Journal: J Comb Chem Date: 2010-10-05

2. Construction of functionalized tricyclic dihydropyrazino-quinazolinedione chemotypes via an Ugi/N-acyliminium ion cyclization cascade.

Authors: Steven Gunawan; Christopher Hulme
Journal: Tetrahedron Lett Date: 2013-08-14 Impact factor: 2.415

3. MCR synthesis of a tetracyclic tetrazole scaffold.

Authors: Pravin Patil; Kareem Khoury; Eberhardt Herdtweck; Alexander Dömling
Journal: Bioorg Med Chem Date: 2014-12-20 Impact factor: 3.641

4. Towards a facile and convenient synthesis of highly functionalized indole derivatives based on multi-component reactions.

Authors: Constantinos G Neochoritis; Alexander Dömling
Journal: Org Biomol Chem Date: 2014-03-14 Impact factor: 3.876

Efficient and diverse synthesis of indole derivatives.

Review 1. Comprehensive survey of chemical libraries for drug discovery and chemical biology: 2009.

2. Construction of functionalized tricyclic dihydropyrazino-quinazolinedione chemotypes via an Ugi/N-acyliminium ion cyclization cascade.

3. MCR synthesis of a tetracyclic tetrazole scaffold.

4. Towards a facile and convenient synthesis of highly functionalized indole derivatives based on multi-component reactions.

5. Polycyclic compounds by Ugi-Pictet-Spengler sequence.

6. MCR synthesis of praziquantel derivatives.

7. Various cyclization scaffolds by a truly Ugi 4-CR.

8. Tricycles by a new Ugi variation and Pictet-Spengler reaction in one pot.

9. Diverse Isoquinoline Scaffolds by Ugi/Pomeranz-Fritsch and Ugi/Schlittler-Müller Reactions.

Review 10. The Pictet-Spengler Reaction Updates Its Habits.