Literature DB >> 24450649

mRNA deadenylation by Pan2-Pan3.

Jana Wolf1, Lori A Passmore1.   

Abstract

Poly(A) tails are important regulators of mRNA stability and translational efficiency. Cytoplasmic removal of poly(A) tails by 3'→5' exonucleases (deadenylation) is the rate-limiting step in mRNA degradation. Two exonuclease complexes contribute the majority of the deadenylation activity in eukaryotes: Ccr4-Not and Pan2-Pan3. These can be specifically recruited to mRNA to regulate mRNA stability or translational efficiency, thereby fine-tuning gene expression. In the present review, we discuss the activities and roles of the Pan2-Pan3 deadenylation complex.

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Year:  2014        PMID: 24450649      PMCID: PMC3992365          DOI: 10.1042/BST20130211

Source DB:  PubMed          Journal:  Biochem Soc Trans        ISSN: 0300-5127            Impact factor:   5.407


  49 in total

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Journal:  Nat Struct Mol Biol       Date:  2004-02       Impact factor: 15.369

2.  GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.

Authors:  Joerg E Braun; Eric Huntzinger; Maria Fauser; Elisa Izaurralde
Journal:  Mol Cell       Date:  2011-10-07       Impact factor: 17.970

3.  A turnover pathway for both stable and unstable mRNAs in yeast: evidence for a requirement for deadenylation.

Authors:  C J Decker; R Parker
Journal:  Genes Dev       Date:  1993-08       Impact factor: 11.361

4.  Rrp6p controls mRNA poly(A) tail length and its decoration with poly(A) binding proteins.

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Journal:  Mol Cell       Date:  2012-06-07       Impact factor: 17.970

5.  Yeast mRNA Poly(A) tail length control can be reconstituted in vitro in the absence of Pab1p-dependent Poly(A) nuclease activity.

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Journal:  J Biol Chem       Date:  2005-05-12       Impact factor: 5.157

6.  The proofreading domain of Escherichia coli DNA polymerase I and other DNA and/or RNA exonuclease domains.

Authors:  M J Moser; W R Holley; A Chatterjee; I S Mian
Journal:  Nucleic Acids Res       Date:  1997-12-15       Impact factor: 16.971

7.  The yeast Pan2 protein is required for poly(A)-binding protein-stimulated poly(A)-nuclease activity.

Authors:  R Boeck; S Tarun; M Rieger; J A Deardorff; S Müller-Auer; A B Sachs
Journal:  J Biol Chem       Date:  1996-01-05       Impact factor: 5.157

8.  Poly(A) tail length control in Saccharomyces cerevisiae occurs by message-specific deadenylation.

Authors:  C E Brown; A B Sachs
Journal:  Mol Cell Biol       Date:  1998-11       Impact factor: 4.272

9.  Identification of a human cytoplasmic poly(A) nuclease complex stimulated by poly(A)-binding protein.

Authors:  Naoyuki Uchida; Shin-Ichi Hoshino; Toshiaki Katada
Journal:  J Biol Chem       Date:  2003-10-28       Impact factor: 5.157

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Journal:  RNA       Date:  2013-05-22       Impact factor: 4.942

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2.  PAN-orama: three convergent views of a eukaryotic deadenylase.

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Journal:  Nat Struct Mol Biol       Date:  2014-07       Impact factor: 15.369

Review 3.  The Interplay between the RNA Decay and Translation Machinery in Eukaryotes.

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Journal:  Cold Spring Harb Perspect Biol       Date:  2018-05-01       Impact factor: 10.005

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Journal:  Front Oncol       Date:  2022-07-04       Impact factor: 5.738

Review 7.  How miRs and mRNA deadenylases could post-transcriptionally regulate expression of tumor-promoting protein PLD.

Authors:  Julian Gomez-Cambronero; Kristen Fite; Taylor E Miller
Journal:  Adv Biol Regul       Date:  2017-08-24

Review 8.  Structural and molecular mechanisms for the control of eukaryotic 5'-3' mRNA decay.

Authors:  Jeffrey S Mugridge; Jeff Coller; John D Gross
Journal:  Nat Struct Mol Biol       Date:  2018-12-05       Impact factor: 15.369

9.  The CNOT4 Subunit of the CCR4-NOT Complex is Involved in mRNA Degradation, Efficient DNA Damage Repair, and XY Chromosome Crossover during Male Germ Cell Meiosis.

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10.  Dedifferentiation of Arabidopsis thaliana cells is accompanied by a strong decrease in RNA polymerase II transcription activity and poly(A+) RNA and 25S rRNA eradication from the cytoplasm.

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