Literature DB >> 24406927

Clinical development success rates for investigational drugs.

Michael Hay1, David W Thomas2, John L Craighead3, Celia Economides2, Jesse Rosenthal1.   

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Year:  2014        PMID： 24406927     DOI： 10.1038/nbt.2786

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


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  12 in total

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Authors:  I M Cockburn; R M Henderson
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2.  Risks in new drug development: approval success rates for investigational drugs.

Authors:  J A Dimasi
Journal:  Clin Pharmacol Ther       Date:  2001-05       Impact factor: 6.875

3.  The price of innovation: new estimates of drug development costs.

Authors:  Joseph A DiMasi; Ronald W Hansen; Henry G Grabowski
Journal:  J Health Econ       Date:  2003-03       Impact factor: 3.883

Review 4.  Can the pharmaceutical industry reduce attrition rates?

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Journal:  Nat Rev Drug Discov       Date:  2004-08       Impact factor: 84.694

Review 5.  Pharmaceutical innovation in the 21st century: new drug approvals in the first decade, 2000-2009.

Authors:  K I Kaitin; J A DiMasi
Journal:  Clin Pharmacol Ther       Date:  2010-12-29       Impact factor: 6.875

6.  Productivity in pharmaceutical-biotechnology R&D: the role of experience and alliances.

Authors:  Patricia M Danzon; Sean Nicholson; Nuno Sousa Pereira
Journal:  J Health Econ       Date:  2005-01-25       Impact factor: 3.883

Review 7.  Macro trends in pharmaceutical innovation.

Authors:  Fredric J Cohen
Journal:  Nat Rev Drug Discov       Date:  2005-01       Impact factor: 84.694

8.  2012 FDA drug approvals.

Authors:  Asher Mullard
Journal:  Nat Rev Drug Discov       Date:  2013-02       Impact factor: 84.694

9.  Success rates for new drugs entering clinical testing in the United States.

Authors:  J A DiMasi
Journal:  Clin Pharmacol Ther       Date:  1995-07       Impact factor: 6.875

10.  Success rates in the United States drug development system.

Authors:  L Sheck; C Cox; H T Davis; A G Trimble; W M Wardell; R Hansen
Journal:  Clin Pharmacol Ther       Date:  1984-11       Impact factor: 6.875
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Journal:  Nat Rev Genet       Date:  2015-09-15       Impact factor: 53.242

2.  Pharma Success in Product Development—Does Biotechnology Change the Paradigm in Product Development and Attrition.

Authors:  Ronald P Evens
Journal:  AAPS J       Date:  2016-01       Impact factor: 4.009

Review 3.  Protective alleles and modifier variants in human health and disease.

Authors:  Andrew R Harper; Shalini Nayee; Eric J Topol
Journal:  Nat Rev Genet       Date:  2015-10-27       Impact factor: 53.242

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Journal:  Nat Rev Clin Oncol       Date:  2015-11-10       Impact factor: 66.675

5.  Drug therapy smartens up.

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6.  Use of big data in drug development for precision medicine.

Authors:  Rosa S Kim; Nicolas Goossens; Yujin Hoshida
Journal:  Expert Rev Precis Med Drug Dev       Date:  2016-04-28

7.  Tissue-Engineered Human Myobundle System as a Platform for Evaluation of Skeletal Muscle Injury Biomarkers.

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8.  Estimation of clinical trial success rates and related parameters.

Authors:  Chi Heem Wong; Kien Wei Siah; Andrew W Lo
Journal:  Biostatistics       Date:  2019-04-01       Impact factor: 5.899

Review 9.  Strategies for targeting the cardiac sarcomere: avenues for novel drug discovery.

Authors:  Joshua B Holmes; Chang Yoon Doh; Ranganath Mamidi; Jiayang Li; Julian E Stelzer
Journal:  Expert Opin Drug Discov       Date:  2020-02-18       Impact factor: 6.098

10.  Laboratory mice born to wild mice have natural microbiota and model human immune responses.

Authors:  Jasmin Herz; Brian G Vassallo; Stephan P Rosshart; Ashli Hunter; Morgan K Wall; Jonathan H Badger; John A McCulloch; Dimitrios G Anastasakis; Aishe A Sarshad; Irina Leonardi; Nicholas Collins; Joshua A Blatter; Seong-Ji Han; Samira Tamoutounour; Svetlana Potapova; Mark B Foster St Claire; Wuxing Yuan; Shurjo K Sen; Matthew S Dreier; Benedikt Hild; Markus Hafner; David Wang; Iliyan D Iliev; Yasmine Belkaid; Giorgio Trinchieri; Barbara Rehermann
Journal:  Science       Date:  2019-08-01       Impact factor: 47.728
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