Literature DB >> 15688075

Macro trends in pharmaceutical innovation.

Fredric J Cohen1.   

Abstract

Critics decry the lack of 'truly innovative' new medicines and question the role of the pharmaceutical industry in creating the few that are developed. Is this an accurate portrayal of the state of pharmaceutical innovation? Does major pharma still innovate? If so, how? Must the industry innovate to survive? These and related issues are discussed.

Mesh：

Substances：

Year:  2005        PMID： 15688075     DOI： 10.1038/nrd1610

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  16 in total

Review 1.  How to improve R&D productivity: the pharmaceutical industry's grand challenge.

Authors:  Steven M Paul; Daniel S Mytelka; Christopher T Dunwiddie; Charles C Persinger; Bernard H Munos; Stacy R Lindborg; Aaron L Schacht
Journal:  Nat Rev Drug Discov       Date:  2010-02-19       Impact factor: 84.694

2.  Old drugs--new uses.

Authors:  J K Aronson
Journal:  Br J Clin Pharmacol       Date:  2007-11       Impact factor: 4.335

3.  Repurposing an old drug for a new use: glybenclamide exerts antiplatelet activity by interacting with the thromboxane A(2) receptor.

Authors:  Harold J Ting; Wallace J Murray; Fadi T Khasawneh
Journal:  Acta Pharmacol Sin       Date:  2010-02       Impact factor: 6.150

4.  Clinical development success rates for investigational drugs.

Authors:  Michael Hay; David W Thomas; John L Craighead; Celia Economides; Jesse Rosenthal
Journal:  Nat Biotechnol       Date:  2014-01       Impact factor: 54.908

Review 5.  Drug repurposing for the treatment of staphylococcal infections.

Authors:  Shankar Thangamani; Haroon Mohammad; Waleed Younis; Mohamed N Seleem
Journal:  Curr Pharm Des       Date:  2015       Impact factor: 3.116

6.  Decline in new drug launches: myth or reality? Retrospective observational study using 30 years of data from the UK.

Authors:  Derek J Ward; Orsolina I Martino; Sue Simpson; Andrew J Stevens
Journal:  BMJ Open       Date:  2013-02-20       Impact factor: 2.692

7.  Minds, motherboards, and money: futurism and realism in the neuroethics of BCI technologies.

Authors:  Mark A Attiah; Martha J Farah
Journal:  Front Syst Neurosci       Date:  2014-05-15

8.  How innovative are new drugs launched in the UK? A retrospective study of new drugs listed in the British National Formulary (BNF) 2001-2012.

Authors:  Derek J Ward; Angharad Slade; Tracey Genus; Orsolina I Martino; Andrew J Stevens
Journal:  BMJ Open       Date:  2014-10-24       Impact factor: 2.692

9.  Metabolomic profiling of drug responses in acute myeloid leukaemia cell lines.

Authors:  Stefano Tiziani; Alessia Lodi; Farhat L Khanim; Mark R Viant; Christopher M Bunce; Ulrich L Günther
Journal:  PLoS One       Date:  2009-01-22       Impact factor: 3.240

10.  Clinical Trial Risk in Hepatitis C: Endpoint Selection and Drug Action.

Authors:  Nicole A Tillie; Jayson L Parker; Jordan J Feld
Journal:  Can J Gastroenterol Hepatol       Date:  2016-03-30
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.