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Literature DB >> 26370900

Using human genetics to make new medicines.

Jeffrey C Barrett^1,2,3, Ian Dunham^1,2,3, Ewan Birney³.

Abstract

Jeffrey Barrett, Ian Dunham and Ewan Birney discuss the initiatives of the newly founded Centre for Therapeutic Target Validation, including a range of approaches to use human genetics to inform drug discovery and make better medicines.

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Year: 2015 PMID： 26370900 DOI： 10.1038/nrg3998

Source DB: PubMed Journal: Nat Rev Genet ISSN： 1471-0056 Impact factor: 53.242

5 in total

1. The support of human genetic evidence for approved drug indications.

Authors: Matthew R Nelson; Hannah Tipney; Jeffery L Painter; Judong Shen; Paola Nicoletti; Yufeng Shen; Aris Floratos; Pak Chung Sham; Mulin Jun Li; Junwen Wang; Lon R Cardon; John C Whittaker; Philippe Sanseau
Journal: Nat Genet Date: 2015-06-29 Impact factor: 38.330

2. Clinical development success rates for investigational drugs.

Authors: Michael Hay; David W Thomas; John L Craighead; Celia Economides; Jesse Rosenthal
Journal: Nat Biotechnol Date: 2014-01 Impact factor: 54.908

3. Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease.

Authors: Giovanni Monteleone; Markus F Neurath; Sandro Ardizzone; Antonio Di Sabatino; Massimo C Fantini; Fabiana Castiglione; Maria L Scribano; Alessandro Armuzzi; Flavio Caprioli; Giacomo C Sturniolo; Francesca Rogai; Maurizio Vecchi; Raja Atreya; Fabrizio Bossa; Sara Onali; Maria Fichera; Gino R Corazza; Livia Biancone; Vincenzo Savarino; Roberta Pica; Ambrogio Orlando; Francesco Pallone
Journal: N Engl J Med Date: 2015-03-19 Impact factor: 91.245

Review 4. Mendelian randomization: genetic anchors for causal inference in epidemiological studies.

Authors: George Davey Smith; Gibran Hemani
Journal: Hum Mol Genet Date: 2014-07-04 Impact factor: 6.150

5. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Authors: Luke Jostins; Stephan Ripke; Rinse K Weersma; Richard H Duerr; Dermot P McGovern; Ken Y Hui; James C Lee; L Philip Schumm; Yashoda Sharma; Carl A Anderson; Jonah Essers; Mitja Mitrovic; Kaida Ning; Isabelle Cleynen; Emilie Theatre; Sarah L Spain; Soumya Raychaudhuri; Philippe Goyette; Zhi Wei; Clara Abraham; Jean-Paul Achkar; Tariq Ahmad; Leila Amininejad; Ashwin N Ananthakrishnan; Vibeke Andersen; Jane M Andrews; Leonard Baidoo; Tobias Balschun; Peter A Bampton; Alain Bitton; Gabrielle Boucher; Stephan Brand; Carsten Büning; Ariella Cohain; Sven Cichon; Mauro D'Amato; Dirk De Jong; Kathy L Devaney; Marla Dubinsky; Cathryn Edwards; David Ellinghaus; Lynnette R Ferguson; Denis Franchimont; Karin Fransen; Richard Gearry; Michel Georges; Christian Gieger; Jürgen Glas; Talin Haritunians; Ailsa Hart; Chris Hawkey; Matija Hedl; Xinli Hu; Tom H Karlsen; Limas Kupcinskas; Subra Kugathasan; Anna Latiano; Debby Laukens; Ian C Lawrance; Charlie W Lees; Edouard Louis; Gillian Mahy; John Mansfield; Angharad R Morgan; Craig Mowat; William Newman; Orazio Palmieri; Cyriel Y Ponsioen; Uros Potocnik; Natalie J Prescott; Miguel Regueiro; Jerome I Rotter; Richard K Russell; Jeremy D Sanderson; Miquel Sans; Jack Satsangi; Stefan Schreiber; Lisa A Simms; Jurgita Sventoraityte; Stephan R Targan; Kent D Taylor; Mark Tremelling; Hein W Verspaget; Martine De Vos; Cisca Wijmenga; David C Wilson; Juliane Winkelmann; Ramnik J Xavier; Sebastian Zeissig; Bin Zhang; Clarence K Zhang; Hongyu Zhao; Mark S Silverberg; Vito Annese; Hakon Hakonarson; Steven R Brant; Graham Radford-Smith; Christopher G Mathew; John D Rioux; Eric E Schadt; Mark J Daly; Andre Franke; Miles Parkes; Severine Vermeire; Jeffrey C Barrett; Judy H Cho
Journal: Nature Date: 2012-11-01 Impact factor: 49.962

5 in total

15 in total

Review 1. Personalized Therapy of Hypertension: the Past and the Future.

Authors: Paolo Manunta; Mara Ferrandi; Daniele Cusi; Patrizia Ferrari; Jan Staessen; Giuseppe Bianchi
Journal: Curr Hypertens Rep Date: 2016-03 Impact factor: 5.369

Review 2. Type 2 diabetes: genetic data sharing to advance complex disease research.

Authors: Jason Flannick; Jose C Florez
Journal: Nat Rev Genet Date: 2016-07-11 Impact factor: 53.242

Review 3. A Review of Recent Advances in Translational Bioinformatics: Bridges from Biology to Medicine.

Authors: J Vamathevan; E Birney
Journal: Yearb Med Inform Date: 2017-09-11

Review 4. Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences.

Authors: Ryan Bogdan; David A A Baranger; Arpana Agrawal
Journal: Annu Rev Clin Psychol Date: 2018-05-07 Impact factor: 18.561

5. eQTLs Weighted Genetic Correlation Analysis Detected Brain Region Differences in Genetic Correlations for Complex Psychiatric Disorders.

Authors: Yan Wen; Feng Zhang; Xiancang Ma; Qianrui Fan; Wenyu Wang; Jiawen Xu; Feng Zhu; Jingcan Hao; Awen He; Li Liu; Xiao Liang; Yanan Du; Ping Li; Cuiyan Wu; Sen Wang; Xi Wang; Yujie Ning; Xiong Guo
Journal: Schizophr Bull Date: 2019-04-25 Impact factor: 9.306

Using human genetics to make new medicines.

1. The support of human genetic evidence for approved drug indications.

2. Clinical development success rates for investigational drugs.

3. Mongersen, an oral SMAD7 antisense oligonucleotide, and Crohn's disease.

Review 4. Mendelian randomization: genetic anchors for causal inference in epidemiological studies.

5. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

Review 1. Personalized Therapy of Hypertension: the Past and the Future.

Review 2. Type 2 diabetes: genetic data sharing to advance complex disease research.

Review 3. A Review of Recent Advances in Translational Bioinformatics: Bridges from Biology to Medicine.

Review 4. Polygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences.

5. eQTLs Weighted Genetic Correlation Analysis Detected Brain Region Differences in Genetic Correlations for Complex Psychiatric Disorders.

Review 6. The Musculoskeletal Knowledge Portal: Making Omics Data Useful to the Broader Scientific Community.

7. GW-SEM 2.0: Efficient, Flexible, and Accessible Multivariate GWAS.

Review 8. Beyond Endometriosis Genome-Wide Association Study: From Genomics to Phenomics to the Patient.

Review 9. The impact of genome-wide association studies on the pathophysiology and therapy of cardiovascular disease.

10. In silico prediction of novel therapeutic targets using gene-disease association data.