PURPOSE: To improve slice coverage of gradient echo spin echo (GESE) sequences for dynamic susceptibility contrast (DSC) MRI using a simultaneous-multiple-slice (SMS) method. METHODS: Data were acquired on 3 Tesla (T) MR scanners with a 32-channel head coil. To evaluate use of SMS for DSC, an SMS GESE sequence with two-fold slice coverage and same temporal sampling was compared with a standard GESE sequence, both with 2× in-plane acceleration. A signal to noise ratio (SNR) comparison was performed on one healthy subject. Additionally, data with Gadolinium injection were collected on three patients with glioblastoma using both sequences, and perfusion analysis was performed on healthy tissues as well as on tumor. RESULTS: Retained SNR of SMS DSC is 90% for a gradient echo (GE) and 99% for a spin echo (SE) acquisition, compared with a standard acquisition without slice acceleration. Comparing cerebral blood volume maps, it was observed that the results of standard and SMS acquisitions are comparable for both GE and SE images. CONCLUSION: Two-fold slice accelerated DSC MRI achieves similar SNR and perfusion metrics as a standard acquisition, while allowing a significant increase in slice coverage of the brain. The results also point to a possibility to improve temporal sampling rate, while retaining the same slice coverage.
PURPOSE: To improve slice coverage of gradient echo spin echo (GESE) sequences for dynamic susceptibility contrast (DSC) MRI using a simultaneous-multiple-slice (SMS) method. METHODS: Data were acquired on 3 Tesla (T) MR scanners with a 32-channel head coil. To evaluate use of SMS for DSC, an SMS GESE sequence with two-fold slice coverage and same temporal sampling was compared with a standard GESE sequence, both with 2× in-plane acceleration. A signal to noise ratio (SNR) comparison was performed on one healthy subject. Additionally, data with Gadolinium injection were collected on three patients with glioblastoma using both sequences, and perfusion analysis was performed on healthy tissues as well as on tumor. RESULTS: Retained SNR of SMS DSC is 90% for a gradient echo (GE) and 99% for a spin echo (SE) acquisition, compared with a standard acquisition without slice acceleration. Comparing cerebral blood volume maps, it was observed that the results of standard and SMS acquisitions are comparable for both GE and SE images. CONCLUSION: Two-fold slice accelerated DSC MRI achieves similar SNR and perfusion metrics as a standard acquisition, while allowing a significant increase in slice coverage of the brain. The results also point to a possibility to improve temporal sampling rate, while retaining the same slice coverage.
Authors: Mark A Griswold; Peter M Jakob; Robin M Heidemann; Mathias Nittka; Vladimir Jellus; Jianmin Wang; Berthold Kiefer; Axel Haase Journal: Magn Reson Med Date: 2002-06 Impact factor: 4.668
Authors: Felix A Breuer; Martin Blaimer; Robin M Heidemann; Matthias F Mueller; Mark A Griswold; Peter M Jakob Journal: Magn Reson Med Date: 2005-03 Impact factor: 4.668
Authors: Steen Moeller; Essa Yacoub; Cheryl A Olman; Edward Auerbach; John Strupp; Noam Harel; Kâmil Uğurbil Journal: Magn Reson Med Date: 2010-05 Impact factor: 4.668
Authors: K M Donahue; H G Krouwer; S D Rand; A P Pathak; C S Marszalkowski; S C Censky; R W Prost Journal: Magn Reson Med Date: 2000-06 Impact factor: 4.668
Authors: Mark Jenkinson; Christian F Beckmann; Timothy E J Behrens; Mark W Woolrich; Stephen M Smith Journal: Neuroimage Date: 2011-09-16 Impact factor: 6.556
Authors: David A Feinberg; Steen Moeller; Stephen M Smith; Edward Auerbach; Sudhir Ramanna; Matthias Gunther; Matt F Glasser; Karla L Miller; Kamil Ugurbil; Essa Yacoub Journal: PLoS One Date: 2010-12-20 Impact factor: 3.240
Authors: Lukas Filli; Marco Piccirelli; David Kenkel; Andreas Boss; Andrei Manoliu; Gustav Andreisek; Himanshu Bhat; Val M Runge; Roman Guggenberger Journal: Eur Radiol Date: 2015-09-15 Impact factor: 5.315
Authors: Borjan A Gagoski; Berkin Bilgic; Cornelius Eichner; Himanshu Bhat; P Ellen Grant; Lawrence L Wald; Kawin Setsompop Journal: Magn Reson Med Date: 2015-02-02 Impact factor: 4.668
Authors: Berkin Bilgic; Borjan A Gagoski; Stephen F Cauley; Audrey P Fan; Jonathan R Polimeni; P Ellen Grant; Lawrence L Wald; Kawin Setsompop Journal: Magn Reson Med Date: 2014-07-01 Impact factor: 4.668
Authors: Fuyixue Wang; Zijing Dong; Timothy G Reese; Berkin Bilgic; Mary Katherine Manhard; Jingyuan Chen; Jonathan R Polimeni; Lawrence L Wald; Kawin Setsompop Journal: Magn Reson Med Date: 2019-02-03 Impact factor: 4.668
Authors: Andreas Stadlbauer; Kim Mouridsen; Arnd Doerfler; Mikkel Bo Hansen; Stefan Oberndorfer; Max Zimmermann; Michael Buchfelder; Gertraud Heinz; Karl Roessler Journal: J Cereb Blood Flow Metab Date: 2017-02-24 Impact factor: 6.200