Fuyixue Wang1,2, Zijing Dong1,3, Timothy G Reese1, Berkin Bilgic1,4, Mary Katherine Manhard1, Jingyuan Chen1, Jonathan R Polimeni1,2,4, Lawrence L Wald1,2,4, Kawin Setsompop1,2,4. 1. Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, Massachusetts. 2. Harvard-MIT Health Sciences and Technology, MIT, Cambridge, Massachusetts. 3. Department of Electrical Engineering and Computer Science, MIT, Cambridge, Massachusetts. 4. Department of Radiology, Harvard Medical School, Boston, Massachusetts.
Abstract
PURPOSE: To develop an efficient distortion- and blurring-free multi-shot EPI technique for time-resolved multiple-contrast and/or quantitative imaging. METHODS: EPI is a commonly used sequence but suffers from geometric distortions and blurring. Here, we introduce a new multi-shot EPI technique termed echo planar time-resolved imaging (EPTI), which has the ability to rapidly acquire distortion- and blurring-free multi-contrast data set. The EPTI approach performs encoding in ky -t space and uses a new highly accelerated spatio-temporal CAIPI sampling trajectory to take advantage of signal correlation along these dimensions. Through this acquisition and a B0 -informed parallel imaging reconstruction, hundreds of "time-resolved" distortion- and blurring-free images at different TEs across the EPI readout window can be created at sub-millisecond temporal increments using a small number of EPTI shots. Moreover, a method for self-estimation and correction of shot-to-shot B0 variations was developed. Simultaneous multi-slice acquisition was also incorporated to further improve the acquisition efficiency. RESULTS: We evaluated EPTI under varying simulated acceleration factors, B0 -inhomogeneity, and shot-to-shot B0 variations to demonstrate its ability to provide distortion- and blurring-free images at multiple TEs. Two variants of EPTI were demonstrated in vivo at 3T: (1) a combined gradient- and spin-echo EPTI for quantitative mapping of T2 , T2 * , proton density, and susceptibility at 1.1 × 1.1 × 3 mm3 whole-brain in 28 s (0.8 s/slice), and (2) a gradient-echo EPTI, for multi-echo and quantitative T2 * fMRI at 2 × 2 × 3 mm3 whole-brain at a 3.3 s temporal resolution. CONCLUSION: EPTI is a new approach for multi-contrast and/or quantitative imaging that can provide fast acquisition of distortion- and blurring-free images at multiple TEs.
PURPOSE: To develop an efficient distortion- and blurring-free multi-shot EPI technique for time-resolved multiple-contrast and/or quantitative imaging. METHODS: EPI is a commonly used sequence but suffers from geometric distortions and blurring. Here, we introduce a new multi-shot EPI technique termed echo planar time-resolved imaging (EPTI), which has the ability to rapidly acquire distortion- and blurring-free multi-contrast data set. The EPTI approach performs encoding in ky -t space and uses a new highly accelerated spatio-temporal CAIPI sampling trajectory to take advantage of signal correlation along these dimensions. Through this acquisition and a B0 -informed parallel imaging reconstruction, hundreds of "time-resolved" distortion- and blurring-free images at different TEs across the EPI readout window can be created at sub-millisecond temporal increments using a small number of EPTI shots. Moreover, a method for self-estimation and correction of shot-to-shot B0 variations was developed. Simultaneous multi-slice acquisition was also incorporated to further improve the acquisition efficiency. RESULTS: We evaluated EPTI under varying simulated acceleration factors, B0 -inhomogeneity, and shot-to-shot B0 variations to demonstrate its ability to provide distortion- and blurring-free images at multiple TEs. Two variants of EPTI were demonstrated in vivo at 3T: (1) a combined gradient- and spin-echo EPTI for quantitative mapping of T2 , T2 * , proton density, and susceptibility at 1.1 × 1.1 × 3 mm3 whole-brain in 28 s (0.8 s/slice), and (2) a gradient-echo EPTI, for multi-echo and quantitative T2 * fMRI at 2 × 2 × 3 mm3 whole-brain at a 3.3 s temporal resolution. CONCLUSION: EPTI is a new approach for multi-contrast and/or quantitative imaging that can provide fast acquisition of distortion- and blurring-free images at multiple TEs.
Authors: Mark A Griswold; Peter M Jakob; Robin M Heidemann; Mathias Nittka; Vladimir Jellus; Jianmin Wang; Berthold Kiefer; Axel Haase Journal: Magn Reson Med Date: 2002-06 Impact factor: 4.668
Authors: Philip M Robson; Aaron K Grant; Ananth J Madhuranthakam; Riccardo Lattanzi; Daniel K Sodickson; Charles A McKenzie Journal: Magn Reson Med Date: 2008-10 Impact factor: 4.668
Authors: Fuyixue Wang; Berkin Bilgic; Zijing Dong; Mary Kate Manhard; Ned Ohringer; Bo Zhao; Melissa Haskell; Stephen F Cauley; Qiuyun Fan; Thomas Witzel; Elfar Adalsteinsson; Lawrence L Wald; Kawin Setsompop Journal: Magn Reson Med Date: 2018-04-01 Impact factor: 4.668
Authors: Jeffrey N Stout; Congyu Liao; Borjan Gagoski; Esra Abaci Turk; Henry A Feldman; Carolina Bibbo; William H Barth; Scott A Shainker; Lawrence L Wald; P Ellen Grant; Elfar Adalsteinsson Journal: Placenta Date: 2021-08-24 Impact factor: 3.287
Authors: Erpeng Dai; Philip K Lee; Zijing Dong; Fanrui Fu; Kawin Setsompop; Jennifer A McNab Journal: IEEE Trans Med Imaging Date: 2021-12-30 Impact factor: 10.048