| Literature DB >> 24180414 |
Kimberly M Bonger1, Rishi Rakhit, Alexander Y Payumo, James K Chen, Thomas J Wandless.
Abstract
Post-translational regulation of protein abundance in cells is a powerful tool for studying protein function. Here, we describe a novel genetically encoded protein domain that is degraded upon exposure to nontoxic blue light. We demonstrate that fusion proteins containing this domain are rapidly degraded in cultured cells and in zebrafish upon illumination.Entities:
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Year: 2013 PMID： 24180414 PMCID： PMC3906921 DOI： 10.1021/cb400755b
Source DB: PubMed Journal: ACS Chem Biol ISSN： 1554-8929 Impact factor: 5.100