Literature DB >> 23346138

Monte Carlo dosimetric study of the Flexisource Co-60 high dose rate source.

Javier Vijande1, Domingo Granero, Jose Perez-Calatayud, Facundo Ballester.   

Abstract

PURPOSE: Recently, a new HDR (60)Co brachytherapy source, Flexisource Co-60, has been developed (Nucletron B.V. Veenendaal, The Netherlands). This study aims to obtain dosimetric data for this source for its use in clinical practice as required by AAPM and ESTRO.
MATERIAL AND METHODS: TWO MONTE CARLO RADIATION TRANSPORT CODES WERE USED: Penelope2008 and GEANT4. The source was centrally-positioned in a 100 cm radius water phantom. Absorbed dose and collisional kerma were obtained using 0.01 cm (close) and 0.1 cm (far) sized voxels to provide high-resolution dosimetry near (far from) the source. Dose rate distributions obtained with the two Monte Carlo codes were compared. RESULTS AND DISCUSSION: Simulations performed with those two radiation transport codes showed an agreement typically within 0.2% for r > 0.8 cm and up to 2% closer to the source. Detailed results of dose distributions are being made available.
CONCLUSIONS: Dosimetric data are provided for the new Flexisource Co-60 source. These data are meant to be used in treatment planning systems in clinical practice.

Entities:  

Keywords:  Flexisource Co-60; GEANT4; Penelope2008; TG-43; brachytherapy

Year:  2012        PMID: 23346138      PMCID: PMC3551374          DOI: 10.5114/jcb.2012.27950

Source DB:  PubMed          Journal:  J Contemp Brachytherapy        ISSN: 2081-2841


Purpose

According to the American Association of Physicist in Medicine (AAPM) and the European Society for Radiotherapy and Oncology (ESTRO) recommendations [1], in order to fulfil the dosimetric prerequisites, all sources to be used in clinical practice have to have a set of dosimetric parameters available based on the Radiation Therapy Committee Task Group No. 43 (TG-43) formalism [2, 3]. The AAPM High Energy Brachytherapy Source Dosimetry Working Group (HEBD-WG) recommends [1] that this dataset must be based upon at least one experimental study and at least one Monte Carlo (MC) study of the model's source dosimetric parameters. For conventionally encapsulated sources similar in design to existing or previously existing ones, a single dosimetric study published in a peer-reviewed journal is sufficient. The high dose rate (HDR) 60Co sources fall in this category. MC or experimental dosimetry (or both) methods may be used. These studies must be performed by investigators that are independent from the manufacturer and published in a peer-reviewed journal prior to the use of these isotopes in clinical practice. The HEBD-WG is also concerned about the dosimetry in the near-source region where the influence of β electrons and the lack of electronic equilibrium are frequently neglected [4-6]. Commercial treatment planning systems (TPS) allow direct introduction of tabulated dose rates from the literature using the TG-43 formalism. These TG-43 data are usually derived from MC radiation transport simulations, estimating absorbed dose by collisional kerma. Consequently, these data are provided at distances from the source capsule large enough to ensure that the equivalence of collisional kerma and dose is applicable. TPS extrapolate data outside the available TG-43 data range. In case of HDR 60Co sources, kerma to dose differences are significant and source model specific [4]. Kerma extrapolation at short distances would not be necessary if TG-43 data were available with adequate range and spatial resolution that include source electron contributions to absorbed dose and account for electron disequilibrium. High dose rate (HDR) brachytherapy 60Co sources have been considered for use in clinical practice as an alternative for 192Ir HDR sources [7]. A comparison between the radio-logical properties of cobalt and iridium HDR sources have been performed in reference [8]. Additionally to cost and logistics improvements due to the cobalt longer half life, clinical examples for intracavitary and interstitial applications show practically identical dose distributions. The main goal of this work is to present the TG-43 data and the 2D dose rate table in cylindrical coordinates for treatment planning and quality assurance purposes (QA) for the new Flexisource Co-60 HDR source model used by the Flexitron remote HDR afterloader (Nucletron B.V., Veenendaal, The Netherlands) in a consistent way that is valid at short and long distances. Such a source has not been studied and published previously.

Material and methods

The design and materials of the Flexisource Co-60 HDR source was provided by the manufacturer. The source design and dimensions are shown schematically in Fig. 1. It is composed of a central cylindrical active core made of metallic 60Co with a density of 8.9 g/cm3, 3.5 mm in length and 0.5 mm in diameter. The active core is covered by a cylindrical 316L stainless steel (67% Fe, 11% Ni, 18% Cr, 2% Si, 2% Mn) layer of 0.9 mm of external diameter and a density of 8 g/cm3. For this study we considered 2 mm 316L steel cable with an effective density of 4.81 g/cm3 (measured from the inner clamp). The interstitial areas between the active element and the cover were considered to be filled with standard dry air.
Fig. 1

Schematic design and dimensions of the model Flexisource Co-60 HDR source. Dimensions are given in mm

Schematic design and dimensions of the model Flexisource Co-60 HDR source. Dimensions are given in mm MC methods for radiation transport simulations were used to study the dose rate distribution around the source. Different MC codes presented different physics models, different cross sections data, and dissimilar tracking methods in the transport of electrons. As dose at short distances from the source was required, where electronic disequilibrium conditions may be dosimetrically important, two different MC codes were used. These MC codes were Penelope2008 [9] and GEANT4 (version 9.3) [10], which have been successfully used for dosimetric studies in the field of the brachytherapy [4, 11–15]. GEANT4 and Penelope2008 photon and electron cross-sections are based on the EPDL97 and EEDL97 cross sections libraries, respectively [16, 17]. However, Penelope2008 also considers the impulse approximation that accounts for Doppler broadening and binding effects [9]. Consequently, photoelectric effect, pair production and Rayleigh cross-sections used by both codes were the same, while Compton cross-sections in Penelope2008 differed from those of GEANT4. Possible influence on the dosimetric results by using Penelope2008 with the Compton cross-sections of the EPDL97 library has been discussed elsewhere [14] and found to be negligible. The photon spectrum was taken from the NuDat database [18] as suggested in Ref. [19]. The number of photons N generated in each simulation was as follows: Penelope2008 (N = 5 × 109), GEANT4 (N = 1 × 109 to obtain water kerma and N = 4 × 109 to calculate absorbed dose). The electron spectrum including β decay, internal conversion electrons (IC) and Auger electrons was not considered in the simulation since its effect over the total dose was known to be less than 1% at distances greater than 0.1 cm from the source surface [4]. In each disintegration, 2.0001 photons/(Bq s) were generated on average. However, due to the 10 keV cut-off used, the photon intensity was reduced to 1.9985 photons/(Bq s). Dose to water contribution was calculated in Penelope2008 using the tally provided within the penEasy package [20], whereas in GEANT4 it was evaluated using a homemade routine with the function GetTotalEnergy-Deposit of the GEANT4 toolkit. To estimate the collisional kerma, homemade routines using the linear track-length estimator [21] were developed for Penelope2008 and GEANT4. Dose and collisional kerma rate distributions were used to derive the final dosimetric parameters as a function of r at every polar angle sampled. The source was located at the geometric center of a spherical liquid water phantom with 100 cm radius, to estimate dose to water and simulate unbounded phantom conditions for r < 20 cm [22]. Water composition and mass density were those recommended by the AAPM [3]. Due to the high energy of the 60Co, the photon spectrum electronic equilibrium is not reached up to a distance of approximately 0.75 cm from the surface of the source [4]. Thus, the dose for small distances cannot be approximated by collisional kerma as is usually done for 192Ir or 137Cs sources. Differences between collisional kerma and dose at r = 0.75 cm are less than 0.5% and negligible at r = 1 cm [4]. Since the evaluation of collisional kerma was more efficient (reduced statistical uncertainty and improved numerical performance) we have considered absorbed dose to water for distances smaller than 0.75 cm and collisional kerma from 0.75 cm up to 20 cm. In order to provide adequate spatial resolution, the cells were 0.01 cm in thickness for r < 2 cm from the source and a factor of 10 thicker for 2 cm < r < 20 cm, respectively. Collisional kerma and absorbed dose were obtained simultaneously in cylindrical (y,z) and spherical (r,θ) coordinates. Angular sampling was taken every 2°. Additional simulations were performed to obtain S with the source surrounded by vacuum, except for a small cylindrical air cell of 0.1 cm in diameter and 0.1 cm in height at r = 10 cm, as recommended by AAPM [3]. Mass-energy absorption coefficients in water and air were consistently derived for each code and used to calculate the collisional kerma.

Results

The dose rate distribution Ḋ(r,θ) for the Flexisource Co-60 HDR source model constructed as described in Sect. Material and Methods was used to derive the TG-43 dosimetry parameters with L = 0.35 cm. Using Penelope2008 and GEANT4, an average of Λ = 1.085 ± 0.003 cGy/(h U) (with k = 1) was obtained. Uncertainties are Type A only. These are similar to the consensus values published for other 60Co sources, see Table 1. In Tables 2 and 3 g (r) and F(r,θ) are provided in 0.1 cm steps (or smaller) up to 1.0 cm from the source (to reproduce the dose distribution accurately at close distances) and in 0.5 cm and 1 cm steps up to 20 cm. Both functions were obtained as average results from Penelope2008 and GEANT4 codes. F(r,θ) was provided for all radial distances in 2° increments. An along-away table for QA purposes is also provided in Table 4.
Table 1

Comparison of dose rate constant values calculated for similar 60Co HDR sources

L (cm)Λ(cGy h−1 U−1)Λ/G (r = 1 cm, θ= 90°) (cGy cm2 h−1 U−1)
Flexisource Co-60 (This work)0.351.085 ± 0.0031.096
BEBIG Multisource GK60M21 [10] 0.351.084 ± 0.0051.095
BEBIG Multisource Co0.A86 [12] 0.351.090 ± 0.0101.098
Ralstron Type 2 [8] 0.201.101 ± 0.0051.105
GZP6 source (Ch. 6) [13] 0.351.086 ± 0.0051.097
GZP6 source (Ch. 3/4) [13] 0.351.087 ± 0.0051.098
Table 2

Radial dose function calculated for the Flexisource Co-60 HDR source

r (cm) g L(r)
0.10.837
0.150.971
0.21.045
0.221.065
0.251.079
0.271.081
0.31.080
0.41.054
0.51.031
0.61.021
0.71.012
0.81.004
0.91.002
11.000
1.50.992
20.984
2.50.976
30.967
3.50.960
40.951
4.50.944
50.935
60.919
70.902
80.885
90.868
100.850
110.832
120.814
140.777
160.739
180.701
200.663
Table 3

Anisotropy function calculated for the Flexisource Co-60 HDR source

r/cm
θ°0.10.150.20.220.250.270.30.40.50.60.70.80.911.522.5
0NaNNaNNaNNaN0.6530.6960.7650.9200.9690.9550.9630.9450.9480.9500.9480.9520.952
2NaNNaNNaNNaN0.6590.7000.7650.9170.9710.9650.9680.9550.9550.9560.9540.9560.955
4NaNNaNNaNNaN0.6650.7040.7650.9150.9730.9750.9740.9600.9610.9610.9600.9590.959
6NaNNaNNaNNaN0.6630.7060.7700.9230.9750.9760.9750.9620.9610.9610.9600.9590.960
8NaNNaNNaNNaN0.6670.7110.7750.9290.9770.9740.9770.9650.9630.9640.9630.9630.963
10NaNNaNNaNNaN0.6750.7170.7810.9350.9770.9760.9750.9690.9690.9690.9670.9670.967
12NaNNaNNaNNaN0.6850.7270.7900.9360.9790.9780.9830.9720.9710.9720.9720.9710.972
14NaNNaNNaN0.6100.6900.7360.8000.9440.9830.9800.9860.9760.9750.9760.9750.9750.975
16NaNNaN0.5960.6370.7040.7490.8110.9440.9860.9840.9880.9780.9780.9780.9780.9770.978
18NaNNaN0.6330.6650.7210.7620.8210.9500.9890.9900.9900.9820.9810.9810.9810.9810.981
20NaNNaN0.6750.6950.7430.7800.8340.9540.9920.9920.9920.9840.9840.9840.9850.9840.984
22NaN0.7030.7060.7230.7640.7970.8470.9570.9930.9910.9890.9860.9860.9860.9850.9850.986
24NaN0.7240.7320.7480.7850.8150.8610.9640.9940.9910.9910.9870.9880.9880.9880.9870.988
26NaN0.7420.7570.7720.8060.8330.8740.9700.9970.9940.9930.9890.9890.9890.9890.9880.989
28NaN0.7640.7790.7930.8240.8480.8860.9750.9970.9930.9950.9910.9910.9910.9900.9900.990
30NaN0.7810.8000.8140.8420.8640.8980.9770.9960.9940.9980.9920.9920.9920.9920.9910.992
32NaN0.7950.8180.8320.8590.8790.9100.9810.9980.9950.9990.9930.9920.9920.9920.9920.992
34NaN0.8130.8350.8490.8740.8930.9210.9861.0000.9940.9980.9930.9930.9930.9940.9930.993
36NaN0.8300.8520.8640.8880.9050.9300.9901.0010.9970.9970.9950.9950.9950.9940.9940.994
380.8240.8430.8660.8770.8980.9140.9370.9911.0020.9970.9980.9950.9950.9960.9950.9950.995
400.8390.8570.8810.8920.9100.9240.9450.9951.0051.0001.0030.9950.9950.9960.9950.9950.995
420.8550.8720.8930.9040.9210.9330.9530.9971.0061.0011.0010.9960.9960.9960.9960.9960.996
440.8750.8820.9040.9130.9290.9400.9590.9991.0050.9991.0000.9960.9970.9970.9970.9960.996
460.8920.8950.9140.9240.9390.9490.9651.0021.0021.0011.0030.9970.9970.9980.9970.9960.996
480.9050.9050.9230.9320.9460.9550.9681.0031.0031.0000.9980.9970.9980.9980.9980.9970.998
500.9150.9160.9320.9390.9520.9620.9751.0011.0030.9991.0040.9980.9980.9980.9980.9980.997
520.9240.9240.9380.9460.9580.9660.9780.9991.0040.9991.0050.9980.9980.9980.9980.9980.998
540.9330.9320.9460.9530.9650.9730.9831.0001.0011.0011.0040.9980.9990.9990.9990.9980.998
560.9350.9420.9540.9590.9680.9740.9841.0031.0041.0011.0030.9980.9990.9990.9990.9980.998
580.9430.9480.9600.9660.9740.9790.9871.0041.0051.0001.0030.9980.9991.0000.9990.9980.998
600.9530.9550.9640.9690.9780.9830.9901.0041.0021.0001.0030.9990.9990.9990.9990.9990.999
620.9600.9590.9690.9730.9800.9840.9911.0031.0021.0011.0030.9981.0001.0000.9990.9990.999
640.9640.9660.9730.9760.9810.9850.9911.0031.0021.0011.0050.9991.0001.0001.0000.9990.999
660.9720.9730.9780.9800.9850.9890.9941.0011.0031.0011.0030.9990.9990.9990.9990.9990.999
680.9790.9760.9810.9840.9880.9910.9941.0031.0031.0031.0040.9991.0001.0001.0000.9990.999
700.9830.9810.9840.9860.9910.9940.9971.0021.0010.9991.0030.9991.0001.0001.0000.9990.999
720.9870.9830.9870.9890.9920.9950.9981.0011.0021.0011.0051.0001.0001.0001.0001.0001.000
740.9930.9850.9900.9920.9950.9971.0001.0011.0011.0031.0021.0001.0001.0000.9990.9990.999
760.9950.9910.9940.9950.9960.9971.0001.0001.0011.0021.0001.0001.0001.0011.0000.9990.999
780.9980.9900.9930.9950.9970.9981.0001.0010.9991.0031.0011.0001.0001.0001.0000.9991.000
801.0010.9940.9960.9970.9980.9991.0001.0010.9991.0001.0031.0001.0001.0000.9990.9990.999
821.0050.9950.9960.9970.9980.9981.0001.0000.9991.0001.0031.0001.0001.0001.0001.0001.000
841.0040.9950.9960.9970.9990.9990.9991.0001.0001.0011.0041.0001.0001.0001.0000.9990.999
861.0060.9970.9980.9980.9980.9980.9990.9990.9991.0031.0031.0001.0001.0001.0000.9990.999
881.0080.9991.0000.9990.9980.9980.9980.9981.0021.0021.0051.0001.0011.0011.0001.0001.000
r /cm
θ° 3 3.5 4 4.5 5 6 7 8 9 10 11 12 14 16. 18 20
00.9530.9520.9540.9540.9550.9560.9570.9600.9610.9610.9630.9630.9660.9670.9690.986
20.9560.9560.9570.9570.9580.9590.9600.9620.9620.9630.9650.9650.9670.9680.9700.979
40.9600.9600.9600.9600.9610.9620.9630.9640.9640.9650.9660.9670.9680.9690.9710.971
60.9600.9600.9610.9610.9620.9620.9630.9630.9640.9650.9660.9670.9670.9690.9700.971
80.9640.9640.9650.9650.9660.9660.9670.9680.9680.9690.9690.9700.9710.9720.9730.973
100.9680.9680.9680.9690.9690.9690.9700.9700.9710.9720.9720.9730.9730.9740.9750.976
120.9720.9720.9730.9730.9730.9740.9750.9750.9750.9760.9760.9770.9770.9780.9790.979
140.9760.9760.9760.9760.9760.9770.9770.9780.9780.9780.9790.9790.9800.9800.9810.981
160.9780.9780.9780.9790.9790.9790.9800.9800.9800.9800.9810.9810.9810.9820.9820.982
180.9810.9810.9820.9820.9820.9830.9830.9830.9830.9830.9840.9840.9840.9850.9850.985
200.9840.9840.9850.9850.9850.9850.9860.9860.9860.9860.9860.9870.9860.9870.9870.988
220.9860.9860.9860.9860.9860.9860.9870.9870.9870.9870.9870.9870.9870.9880.9880.988
240.9880.9880.9880.9880.9890.9890.9890.9890.9890.9890.9890.9890.9890.9890.9900.990
260.9890.9890.9890.9890.9890.9900.9900.9900.9900.9900.9900.9900.9900.9910.9910.990
280.9900.9900.9910.9900.9910.9910.9910.9910.9910.9910.9910.9910.9910.9910.9920.992
300.9920.9920.9920.9920.9920.9920.9920.9920.9920.9920.9920.9920.9930.9930.9930.993
320.9920.9920.9920.9920.9920.9930.9930.9930.9920.9930.9930.9930.9930.9930.9930.993
340.9940.9940.9940.9940.9940.9940.9940.9940.9940.9940.9940.9940.9940.9940.9950.994
360.9940.9940.9950.9940.9950.9950.9950.9950.9950.9950.9950.9950.9950.9950.9950.995
380.9950.9950.9950.9950.9950.9950.9950.9950.9950.9950.9950.9950.9950.9950.9950.995
400.9950.9950.9950.9950.9950.9950.9950.9950.9950.9950.9950.9950.9950.9950.9950.995
420.9960.9960.9960.9960.9960.9960.9960.9960.9960.9960.9960.9960.9960.9960.9960.996
440.9960.9960.9970.9970.9970.9970.9970.9970.9970.9970.9970.9970.9970.9970.9970.997
460.9960.9960.9970.9970.9960.9970.9970.9970.9960.9960.9960.9960.9960.9960.9960.996
480.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.998
500.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.998
520.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.999
540.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9990.9980.9980.9980.9990.998
560.9980.9980.9990.9990.9990.9990.9990.9980.9980.9990.9990.9990.9990.9990.9990.999
580.9990.9980.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.999
600.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.999
620.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.999
640.9990.9991.0000.9990.9991.0001.0000.9990.9990.9991.0000.9991.0001.0001.0000.999
660.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.999
680.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9991.0000.999
700.9990.9991.0000.9991.0001.0001.0001.0000.9991.0001.0001.0001.0001.0001.0001.000
721.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.000
740.9990.9990.9990.9990.9990.9991.0000.9990.9990.9990.9990.9990.9990.9991.0000.999
760.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.999
781.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0000.9991.0001.000
800.9990.9990.9990.9990.9990.9991.0000.9990.9990.9990.9990.9991.0000.9990.9990.999
821.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.000
841.0001.0001.0001.0001.0001.0001.0001.0000.9991.0000.9990.9991.0001.0001.0001.000
861.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.000
881.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.000
r /cm
θ° 0.1 0.15 0.2 0.22 0.25 0.27 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 1.5 2 2.5
901.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.000
921.0050.9991.0011.0021.0011.0011.0011.0011.0021.0011.0041.0001.0001.0001.0001.0001.000
941.0060.9981.0001.0001.0011.0011.0011.0001.0011.0011.0051.0001.0001.0011.0001.0001.000
961.0060.9970.9980.9991.0001.0011.0011.0001.0001.0001.0030.9991.0001.0011.0000.9991.000
981.0020.9940.9970.9981.0001.0001.0001.0001.0001.0011.0031.0001.0001.0011.0001.0001.000
1000.9970.9940.9960.9980.9991.0001.0011.0031.0011.0011.0051.0001.0001.0001.0000.9990.999
1020.9970.9910.9940.9950.9970.9981.0001.0011.0021.0021.0070.9991.0011.0011.0001.0001.000
1040.9940.9900.9930.9940.9960.9971.0001.0021.0010.9991.0051.0001.0001.0001.0000.9991.000
1060.9920.9870.9920.9930.9960.9970.9991.0031.0011.0001.0040.9991.0001.0001.0001.0001.000
1080.9880.9840.9900.9920.9950.9960.9991.0051.0011.0001.0021.0001.0001.0001.0000.9991.000
1100.9860.9820.9880.9900.9930.9971.0011.0041.0021.0021.0041.0001.0001.0001.0000.9990.999
1120.9770.9760.9840.9870.9910.9940.9981.0051.0021.0011.0021.0001.0001.0011.0000.9990.999
1140.9760.9720.9780.9810.9870.9910.9981.0041.0030.9991.0040.9991.0001.0000.9990.9990.999
1160.9690.9670.9780.9820.9880.9910.9961.0051.0051.0001.0051.0000.9991.0001.0000.9990.999
1180.9640.9630.9730.9770.9830.9880.9951.0051.0041.0011.0070.9990.9991.0000.9990.9990.999
1200.9530.9570.9700.9750.9810.9860.9931.0071.0041.0021.0050.9990.9990.9990.9990.9990.999
1220.9430.9490.9650.9710.9800.9850.9931.0051.0031.0021.0030.9980.9990.9990.9990.9980.998
1240.9380.9430.9590.9660.9760.9830.9931.0050.9991.0021.0030.9991.0001.0000.9990.9990.999
1260.9340.9360.9530.9610.9720.9790.9901.0051.0001.0011.0030.9980.9990.9990.9990.9980.998
1280.9250.9280.9450.9530.9650.9740.9881.0051.0030.9981.0020.9980.9990.9990.9980.9980.998
1300.9150.9180.9390.9470.9610.9710.9851.0061.0011.0001.0020.9980.9980.9990.9990.9980.998
1320.9010.9100.9330.9430.9570.9670.9811.0051.0041.0001.0030.9980.9980.9990.9980.9980.998
1340.8900.9000.9240.9350.9520.9630.9781.0051.0051.0011.0020.9980.9970.9980.9970.9970.997
1360.8770.8880.9150.9270.9450.9570.9731.0051.0071.0041.0030.9970.9970.9970.9970.9970.997
1380.8560.8770.9050.9170.9360.9500.9681.0031.0071.0041.0020.9960.9970.9970.9970.9970.996
1400.8430.8640.8930.9060.9270.9410.9601.0021.0071.0031.0020.9960.9960.9970.9960.9960.996
1420.8280.8510.8820.8960.9180.9320.9531.0021.0061.0021.0000.9950.9950.9960.9950.9950.995
144NaN0.8350.8680.8840.9070.9230.9460.9991.0061.0051.0000.9940.9950.9960.9950.9940.994
146NaN0.8200.8530.8690.8930.9100.9340.9971.0051.0021.0000.9940.9940.9950.9940.9940.994
148NaN0.8040.8360.8530.8800.8990.9270.9931.0030.9990.9960.9930.9930.9930.9930.9920.992
150NaN0.7870.8190.8370.8670.8880.9190.9881.0051.0000.9970.9920.9920.9920.9910.9900.990
152NaN0.7690.8000.8190.8510.8740.9080.9851.0040.9990.9960.9910.9910.9910.9910.9910.991
154NaN0.7490.7810.8000.8340.8590.8950.9841.0040.9980.9960.9890.9900.9910.9890.9880.988
156NaN0.7290.7600.7800.8160.8430.8820.9741.0020.9970.9960.9870.9870.9870.9870.9870.987
158NaN0.7070.7350.7570.7960.8240.8660.9660.9960.9930.9920.9850.9850.9850.9850.9840.984
160NaNNaN0.7070.7300.7710.8030.8510.9590.9950.9920.9900.9830.9820.9830.9820.9810.981
162NaNNaN0.6750.7010.7460.7810.8350.9540.9930.9920.9860.9790.9780.9790.9780.9770.977
164NaNNaN0.6380.6690.7210.7590.8160.9490.9840.9830.9820.9740.9740.9740.9730.9730.973
166NaNNaNNaN0.6320.6910.7340.7990.9420.9750.9800.9780.9690.9680.9680.9670.9660.967
168NaNNaNNaNNaN0.6610.7080.7780.9350.9730.9720.9660.9610.9600.9600.9600.9600.960
170NaNNaNNaNNaNNaNNaN0.7750.9270.9610.9600.9630.9510.9500.9500.9490.9480.949
172NaNNaNNaNNaNNaNNaNNaN0.9210.9490.9420.9510.9400.9340.9340.9330.9340.935
174NaNNaNNaNNaNNaNNaNNaNNaN0.9290.9270.9390.9260.9180.9180.9180.9180.919
176NaNNaNNaNNaNNaNNaNNaNNaN0.9210.9220.9240.9100.8970.8980.8990.8990.901
178NaNNaNNaNNaNNaNNaNNaNNaN0.9460.9040.9280.9000.8780.8790.8810.8820.884
180NaNNaNNaNNaNNaNNaNNaNNaN0.9720.8860.9320.8980.8580.8610.8630.8640.867
r /cm
θ° 3 3.5 4 4.5 5 6 7 8 9 10 11 12 14 16. 18 20
901.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.000
921.0001.0001.0001.0001.0011.0011.0011.0001.0001.0011.0011.0011.0001.0001.0001.000
941.0001.0001.0001.0001.0001.0001.0011.0011.0001.0001.0001.0001.0011.0001.0001.001
961.0001.0001.0001.0001.0001.0001.0001.0000.9991.0001.0000.9990.9990.9991.0001.000
981.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.000
1001.0000.9991.0001.0001.0001.0001.0001.0000.9991.0001.0001.0000.9991.0000.9991.000
1021.0001.0011.0011.0011.0011.0011.0011.0011.0001.0011.0011.0001.0001.0001.0011.001
1041.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.000
1061.0001.0001.0011.0011.0001.0011.0011.0011.0011.0011.0011.0011.0011.0011.0011.001
1081.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.0001.000
1100.9990.9990.9990.9991.0001.0001.0001.0000.9991.0001.0001.0001.0000.9991.0001.000
1120.9990.9991.0001.0000.9991.0001.0001.0000.9991.0001.0001.0001.0001.0001.0001.000
1141.0000.9990.9991.0001.0001.0001.0000.9991.0001.0001.0001.0001.0000.9990.9990.999
1160.9990.9990.9990.9990.9990.9991.0000.9990.9990.9990.9990.9990.9990.9990.9990.999
1180.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.999
1200.9990.9990.9990.9990.9990.9991.0000.9990.9990.9990.9990.9990.9990.9990.9990.999
1220.9980.9980.9990.9990.9990.9990.9990.9990.9990.9990.9990.9980.9990.9990.9990.999
1240.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.9990.999
1260.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.998
1280.9980.9980.9980.9980.9980.9990.9990.9990.9980.9990.9980.9990.9990.9990.9980.998
1300.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.998
1320.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9980.9970.9970.997
1340.9970.9970.9970.9970.9970.9970.9970.9970.9970.9970.9970.9970.9970.9970.9970.997
1360.9970.9970.9970.9970.9970.9970.9970.9970.9960.9970.9970.9970.9970.9970.9970.997
1380.9960.9960.9960.9960.9960.9960.9960.9960.9960.9960.9960.9960.9960.9960.9960.996
1400.9960.9960.9960.9960.9960.9970.9960.9960.9960.9960.9960.9960.9960.9960.9960.996
1420.9950.9950.9950.9950.9950.9950.9950.9950.9940.9950.9950.9950.9950.9940.9950.994
1440.9950.9950.9950.9950.9950.9950.9950.9950.9950.9950.9950.9950.9950.9950.9950.995
1460.9940.9940.9940.9940.9940.9940.9940.9940.9940.9940.9940.9940.9940.9940.9940.994
1480.9920.9920.9920.9920.9920.9920.9920.9920.9920.9920.9920.9920.9920.9920.9920.992
1500.9910.9910.9910.9910.9910.9910.9910.9910.9910.9910.9910.9910.9910.9910.9910.991
1520.9910.9910.9910.9910.9910.9910.9910.9910.9910.9920.9920.9910.9910.9910.9920.992
1540.9880.9880.9890.9890.9890.9890.9890.9890.9890.9890.9890.9890.9890.9890.9890.989
1560.9870.9870.9870.9870.9870.9870.9870.9870.9870.9870.9870.9870.9870.9880.9880.988
1580.9840.9840.9840.9840.9840.9850.9850.9850.9850.9850.9850.9850.9860.9860.9860.986
1600.9810.9820.9820.9820.9820.9820.9830.9820.9830.9830.9830.9830.9830.9840.9840.984
1620.9770.9770.9770.9770.9780.9780.9780.9790.9780.9790.9790.9790.9790.9800.9800.981
1640.9730.9740.9740.9740.9740.9750.9750.9750.9760.9760.9760.9770.9780.9780.9790.979
1660.9670.9670.9670.9680.9680.9690.9690.9700.9700.9710.9710.9720.9720.9730.9730.974
1680.9610.9610.9610.9620.9620.9630.9640.9640.9650.9660.9660.9670.9670.9680.9690.970
1700.9500.9500.9510.9510.9520.9530.9540.9550.9560.9570.9580.9580.9600.9610.9630.963
1720.9360.9360.9370.9380.9390.9400.9420.9430.9440.9450.9470.9480.9500.9510.9530.955
1740.9210.9220.9230.9240.9250.9270.9290.9310.9320.9350.9360.9370.9400.9420.9440.946
1760.9020.9040.9060.9070.9090.9110.9140.9160.9180.9200.9230.9250.9280.9320.9350.935
1780.8860.8870.8890.8910.8930.8960.8990.9020.9040.9070.9080.9110.9150.9190.9220.914
1800.8690.8710.8720.8760.8770.8800.8840.8890.8900.8930.8930.8970.9020.9060.9080.893
Table 4

Along away (cGy h−1 U−1) table calculated for the Flexisource Co-60 HDR source for QA purposes

y/cm
z/cm0.10.20.30.40.50.60.70.80.91246810
−100.008410.008420.008440.008460.008480.008500.008520.008550.008560.008590.008580.007780.006550.005310.00423
−80.01360.013650.013690.013730.013780.013810.013880.013920.013960.013980.013780.011780.009260.007050.00532
−60.02490.02510.02520.02530.02550.02560.02570.02580.02580.02580.02450.01880.013290.009290.00659
−40.05780.0580.05890.0590.0600.0600.0600.0600.0600.0590.0510.03160.018900.011880.00789
−20.2410.2460.2490.2490.2470.2420.2360.2290.2210.2130.13260.05170.02500.014180.00891
−11.0221.0401.0050.9450.8820.8070.7370.6680.6040.5450.2140.06110.02720.014890.00921
−0.91.2931.2871.2321.1441.0470.9450.8470.7570.6750.6030.2230.06190.02730.014940.00922
−0.81.6721.6371.5361.4011.2531.1110.9770.8580.7550.6660.2310.06250.02740.014980.00924
−0.72.232.151.9651.7411.5131.3081.1280.9730.8420.7330.2390.06310.02760.015020.00926
−0.63.122.942.582.191.8461.5491.3011.0980.9350.8030.2460.06360.02770.015060.00927
−0.5NaN4.213.482.802.261.8261.4921.2321.0320.8730.2530.06410.02770.015080.00928
−0.4NaN6.344.823.612.752.141.6931.3681.1250.9390.2580.06450.02780.015100.00930
−0.3NaN10.016.734.603.292.461.8911.4941.2100.9980.2630.06470.02790.015120.00930
−0.25NaN12.637.885.133.562.611.9821.5501.2471.0230.2640.06480.02790.015130.00931
−0.2NaN15.699.065.643.822.742.061.5981.2781.0440.2660.06490.02790.015140.00931
−0.15NaN18.8010.196.114.032.862.131.6391.3041.0620.2670.06500.02790.015140.00931
−0.1NaN21.411.116.484.202.952.181.6681.3231.0740.2680.06510.02790.015140.00931
−0.05NaN23.111.726.724.313.002.211.6871.3351.0820.2680.06510.02790.015140.00930
0NaN23.711.936.804.353.022.221.6921.3391.0850.2690.06510.02790.015140.00930
0.05NaN23.111.716.714.313.002.211.6871.3351.0820.2680.06510.02790.015140.00930
0.1NaN21.311.096.474.202.942.181.6681.3231.0740.2680.06510.02790.015140.00930
0.15NaN18.6710.166.104.032.852.131.6381.3041.0620.2670.06500.02790.015130.00930
0.2NaN15.529.045.643.812.742.061.5981.2781.0440.2660.06490.02790.015130.00930
0.25NaN12.477.855.123.562.611.9831.5501.2461.0230.2640.06480.02790.015120.00930
0.313.499.896.704.593.292.461.8941.4941.2100.9970.2630.06470.02790.015120.00930
0.47.666.314.803.602.742.141.6971.3671.1250.9390.2580.06440.02780.015100.00929
0.54.794.203.472.802.251.8251.4911.2321.0310.8720.2530.06400.02770.015080.00928
0.63.212.942.572.191.8461.5461.2991.0980.9350.8020.2460.06360.02770.015050.00927
0.72.302.161.9641.7391.5151.3091.1280.9720.8420.7320.2390.06310.02750.015010.00926
0.81.7111.6451.5351.3971.2501.1070.9750.8580.7550.6650.2310.06250.02740.014970.00924
0.91.3381.3001.2321.1431.0440.9430.8460.7560.6750.6030.2230.06180.02730.014930.00922
11.0751.0511.0090.9500.8810.8090.7360.6670.6030.5450.2140.06110.02720.014890.00920
20.2590.2580.2560.2530.2490.2430.2370.2290.2220.2130.13260.05160.02500.014170.00891
40.06220.06230.06230.06210.06190.06160.06130.06090.06040.05980.05120.03160.018900.011890.00789
60.02670.02680.02680.02680.02670.02670.02660.02650.02640.02630.02460.018820.013300.009290.00659
80.014540.014480.014560.014550.014510.014530.014490.014470.014410.014400.013880.011780.009260.007050.00532
100.008920.008940.008930.008950.008940.008930.008940.008930.008910.008910.008700.007780.006550.005310.00423
Comparison of dose rate constant values calculated for similar 60Co HDR sources Radial dose function calculated for the Flexisource Co-60 HDR source Anisotropy function calculated for the Flexisource Co-60 HDR source Along away (cGy h−1 U−1) table calculated for the Flexisource Co-60 HDR source for QA purposes Differences in using D(r,θ) Penelope2008 and GEANT4 were within the statistical uncertainties (type A). These uncertainties were larger at r < 1 cm where absorbed dose were scored (between 0.5% at r = 0.2 cm and 1% at r = 0.8 cm) and lower at larger distances (below 0.1%) where the collisional kerma was used.

Discussions

In this study, we have compared our results with those obtained for other 60Co sources discussed in the literature. Papagiannis et al. [23] used MC to obtain dose rate in water (30 cm in diameter water phantom) of the Ralstron Type-1, Type-2 and Type-3 source models manufacured by Shimazdu Corporation (Japan) and used in the Ralstron remote afterloader. Their configuration consists of two active pellets (cylinders 1 mm × 1 mm) either in contact (Type-2), 9 mm (Type-1) or 11 mm apart (Type-3). All three models have a 3 mm external diameter. Kerma-dose approximation was used. Papagiannis et al. [23] reported along-away dose rate tables and TG-43 dose parameters. Selvam et al. [24] have reported a systematic error for y = 0.75 cm in the away-along table of Papagiannis et al. for the type 2 source model. Ballester et al. [13] studied the GK60M21 60Co (Eckert & Ziegler IBt-Bebig GmbH, Germany) using GEANT4 code to obtain the dose rate distribution around this source in an unbounded water phantom. Only the gamma part of the 60Co spectrum was considered. The β spectrum contribution to the dose was assumed to be insignificant. A cut-off energy of 10 keV was used for both photons and electrons. They scored kerma and dose separately to account for the electronic disequilibrium near the source. For points located at distances of less than 1 cm from the source they scored dose, while for distances where electronic equilibrium was achieved they scored kerma. They derived TG-43U1 parameters and an away-along table. Selvam et al. [25] reproduced the Ballester et al. [13] study, but using the EGSnrc code. They derived only an away-along table. The comparison of away-along tables from both studies reveals consistency between both studies except at y = 0.25 cm and z = −0.25, z = 0 and z = 0.25 cm were the Ballester et al. data had a typo. Granero et al. [11] used GEANT4 MC code to obtain the dose rate distribution for the Co0.A86 60Co source model (Eckert & Ziegler IBt-Bebig GmbH, Germany) in an unbounded water phantom. The same type of study that the Ballester et al. [13], one of the GK60M21 source model described in the previous paragraph was done for the Co0.A86 source model. Selvam et al. [25] also reproduced the Granero et al. [11] study, but using the EGSnrc code, obtaining only an away-along table. The comparison of away-along tables from both studies reveals that at (y = 0.25 cm, z = –0.25 cm), (y = 0.25 cm, z = 0 cm), (y = 0.25 cm, z = 0.25 cm), the Granero et al. [11] data are underestimated. This is the same typo as in Ballester et al. data [13] for the GK60M21 source model. Tabrizi et al. [26] studied two different 60Co linear braid type sources available for the GZP6 remote afterloader (Nuclear Power Institute of China). These sources are composed of one active core made of metallic 60Co with 3.5 mm length and 1.5 mm diameter, encapsulated in 0.1 mm titanium. The active core is covered by a cylindrical stainless steel cover of 0.5 mm external diameter and steel balls arranged along. The authors used the MCNP4C Monte Carlo code to obtain the TG-43 dosimetric parameters together with along-away dose rate tables. Their radial dose function (see Fig. 2 in Tabrizi et al.) is inconsistent with other 60Co source data and is difficult to understand from a physical point of view.
Fig. 2

A) Radial dose function of 60Co source models. B) Zoom-in at short distances from the source where the electronic disequilibrium is located

A) Radial dose function of 60Co source models. B) Zoom-in at short distances from the source where the electronic disequilibrium is located Papagianis et al. [23] showed that Λ/G (r = 1 cm, θ = 90°) values for different 60Co source models are expected to match each other providing the spatial dependence of the dose rate constant as removed. In Table 1, it can be observed that the Flexisource Co-60 HDR source fits into this scheme. g (r) for the Flexisource Co-60 HDR source is compared in Fig. 2A with corresponding data to GK60M21 [13] and Co0.A86 [11] sources from BEBIG, Ralstron HDR Type 2 [23] from Shimazdu and GZP6 sources [26]. Figure 2B illustrates similarities/differences for r < 1 cm. The differences between Papagianis et al. data and those of the present study are due to the different phantom sizes used in the MC calculations. For the GZP6 source model data present an anomalous pattern. Anisotropy function F(r,θ) is shown in Fig. 3 for r ≤ 1 cm. At larger distances, F(r,θ) behave in a similar way as for r = 1 cm.
Fig. 3

Anisotropy function of the Flexisource Co-60 HDR source model for selected distances

Anisotropy function of the Flexisource Co-60 HDR source model for selected distances

Conclusions

A dosimetric study of the Nucletron Flexisource Co-60 HDR source for which no published dosimetric data existed was performed. TG-43 parameters, dose rate constant, radial dose function and anisotropy function were provided together with a 2D along and away dose table. These datasets can be used either as an input for (or to validate) the TPS calculations essential for clinical practice.
  20 in total

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Authors:  R Wang; X A Li
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3.  Phantom size in brachytherapy source dosimetric studies.

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Journal:  Med Phys       Date:  2004-07       Impact factor: 4.071

4.  Update of AAPM Task Group No. 43 Report: A revised AAPM protocol for brachytherapy dose calculations.

Authors:  Mark J Rivard; Bert M Coursey; Larry A DeWerd; William F Hanson; M Saiful Huq; Geoffrey S Ibbott; Michael G Mitch; Ravinder Nath; Jeffrey F Williamson
Journal:  Med Phys       Date:  2004-03       Impact factor: 4.071

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Authors:  F Ballester; D Granero; J Pérez-Calatayud; E Casal; S Agramunt; R Cases
Journal:  Phys Med Biol       Date:  2005-10-12       Impact factor: 3.609

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Authors:  Zuofeng Li; Rupak K Das; Larry A DeWerd; Geoffrey S Ibbott; Ali S Meigooni; José Pérez-Calatayud; Mark J Rivard; Ronald S Sloboda; Jeffrey F Williamson
Journal:  Med Phys       Date:  2007-01       Impact factor: 4.071

7.  Technical note: Dosimetric study of a new Co-60 source used in brachytherapy.

Authors:  D Granero; J Pérez-Calatayud; F Ballester
Journal:  Med Phys       Date:  2007-09       Impact factor: 4.071

8.  Monte Carlo derivation of AAPM TG-43 dosimetric parameters for GZP6 Co-60 HDR sources.

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Journal:  Phys Med       Date:  2011-05-31       Impact factor: 2.685

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10.  Monte Carlo dosimetry of 60Co HDR brachytherapy sources.

Authors:  P Papagiannis; A Angelopoulos; E Pantelis; L Sakelliou; P Karaiskos; Y Shimizu
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2.  EGSnrc Monte Carlo-aided dosimetric studies of the new BEBIG (60)Co HDR brachytherapy source.

Authors:  Islam Mohammad Anwarul; Mir Md Akramuzzaman; Golam Abu Zakaria
Journal:  J Contemp Brachytherapy       Date:  2013-09-12

3.  Measurements and Monte Carlo calculation of radial dose and anisotropy functions of BEBIG 60Co high-dose-rate brachytherapy source in a bounded water phantom.

Authors:  Buchapudi Rekha Reddy; Marc J P Chamberland; Manickam Ravikumar; Chandraraj Varatharaj
Journal:  J Contemp Brachytherapy       Date:  2019-12-25
  3 in total

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