Literature DB >> 22873944

Palladium(II)-catalyzed enantio- and diastereoselective synthesis of pyrrolidine derivatives.

Ranjan Jana1, Tejas P Pathak, Katrina H Jensen, Matthew S Sigman.   

Abstract

A palladium-catalyzed enantio- and diastereoselective synthesis of pyrrolidine derivatives is described. Initial intramolecular nucleopalladation of the tethered protected amine forms the pyrrolidine moiety and a quinone methide intermediate. A second nucleophile adds intermolecularly to afford diverse products in high enantio- and diastereoselectivity.

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Year:  2012        PMID： 22873944      PMCID： PMC3459323          DOI： 10.1021/ol3016989

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  53 in total

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8.  Stereoselective synthesis of spirocyclic pyrrolidines/pyrrolizidines/pyrrolothiazolidines using l-proline functionalized manganese ferrite nanorods as a novel heterogeneous catalyst.

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9.  Alcohols as Alkylating Agents in the Cation-Induced Formation of Nitrogen Heterocycles.

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  9 in total

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