| Literature DB >> 10882007 |
P Sonnet1, P Dallemagne, J Guillon, C Enguehard, S Stiebing, J Tanguy, R Bureau, S Rault, P Auvray, S Moslemi, P Sourdaine, G E Séralini.
Abstract
We report herein the design and the synthesis of some aryl-substituted pyrrolizine and indolizine derivatives, on the basis of a hypothetical pharmacophore structure designed to fit the catalytic site of the human cytochrome P450 aromatase. The in vitro biological evaluation of these compounds allowed us to point out two new potent non-steroidal aromatase inhibitors, MR 20494 and MR 20492, with IC50 values in the range of 0.1 microM.Entities:
Mesh：
Substances：
Year: 2000 PMID： 10882007 DOI： 10.1016/s0968-0896(00)00024-9
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641