Duy N Mai1, John P Wolfe. 1. Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, USA.
Abstract
The enantioselective synthesis of 2-(arylmethyl)- and 2-(alkenylmethyl)pyrrolidine derivatives via Pd-catalyzed alkene carboamination reactions is described. These transformations generate enantiomerically enriched products with up to 94% ee from readily available alkenyl or aryl bromides and N-boc-pent-4-enylamines. The application of this method to a concise asymmetric synthesis of (-)-tylophorine is also discussed.
The enantioselective synthesis of n class="Chemical">2-(arylmethyl)- and 2-(alkenylmethyl)pyrrolidine derivatives via Pd-catalyzed alkene carboamination reactions is described. These transformations generate enantiomerically enriched products with up to 94% ee from readily available alkenyl oraryl bromides and N-boc-pent-4-enylamines. The application of this method to a concise asymmetric synthesis of (-)-tylophorine is also discussed.
Authors: Derek C Cole; William J Lennox; Sabrina Lombardi; John W Ellingboe; Ronald C Bernotas; Gregory J Tawa; Hossein Mazandarani; Deborah L Smith; Guoming Zhang; Joseph Coupet; Lee E Schechter Journal: J Med Chem Date: 2005-01-27 Impact factor: 7.446
Authors: Emilia J Groso; Alexander N Golonka; Ryan A Harding; Brandon W Alexander; Taylor M Sodano; Corinna S Schindler Journal: ACS Catal Date: 2018-01-18 Impact factor: 13.084