Literature DB >> 22758385

Photocontrol of tyrosine phosphorylation in mammalian cells via genetic encoding of photocaged tyrosine.

Eyal Arbely1, Jessica Torres-Kolbus, Alexander Deiters, Jason W Chin.   

Abstract

We report the first site-specific genetic encoding of photocaged tyrosine into proteins in mammalian cells. By photocaging Tyr701 of STAT1 we demonstrate that it is possible to photocontrol tyrosine phosphorylation and signal transduction in mammalian cells.

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Year:  2012        PMID： 22758385     DOI： 10.1021/ja3046958

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  54 in total

1.  Site-selective protein-modification chemistry for basic biology and drug development.

Authors:  Nikolaus Krall; Filipa P da Cruz; Omar Boutureira; Gonçalo J L Bernardes
Journal:  Nat Chem       Date:  2015-11-30       Impact factor: 24.427

Review 2.  Molecular tools for acute spatiotemporal manipulation of signal transduction.

Authors:  Brian Ross; Sohum Mehta; Jin Zhang
Journal:  Curr Opin Chem Biol       Date:  2016-09-14       Impact factor: 8.822

3.  Optical Control of CRISPR/Cas9 Gene Editing.

Authors:  James Hemphill; Erin K Borchardt; Kalyn Brown; Aravind Asokan; Alexander Deiters
Journal:  J Am Chem Soc       Date:  2015-04-23       Impact factor: 15.419

4.  Palladium-triggered deprotection chemistry for protein activation in living cells.

Authors:  Jie Li; Juntao Yu; Jingyi Zhao; Jie Wang; Siqi Zheng; Shixian Lin; Long Chen; Maiyun Yang; Shang Jia; Xiaoyu Zhang; Peng R Chen
Journal:  Nat Chem       Date:  2014-03-16       Impact factor: 24.427

Review 5.  Histones: at the crossroads of peptide and protein chemistry.

Authors:  Manuel M Müller; Tom W Muir
Journal:  Chem Rev       Date:  2014-10-20       Impact factor: 60.622

6.  An 'on' switch for proteins.

Authors:  Klaus Michael Hahn
Journal:  Nature       Date:  2019-05       Impact factor: 49.962

Review 7.  Optochemical Control of Biological Processes in Cells and Animals.

Authors:  Nicholas Ankenbruck; Taylor Courtney; Yuta Naro; Alexander Deiters
Journal:  Angew Chem Int Ed Engl       Date:  2018-02-01       Impact factor: 15.336

Review 8.  Pyrrolysyl-tRNA synthetase: an ordinary enzyme but an outstanding genetic code expansion tool.

Authors:  Wei Wan; Jeffery M Tharp; Wenshe R Liu
Journal:  Biochim Biophys Acta       Date:  2014-03-12

Review 9.  Therapeutic applications of an expanded genetic code.

Authors:  Sophie B Sun; Peter G Schultz; Chan Hyuk Kim
Journal:  Chembiochem       Date:  2014-07-18       Impact factor: 3.164

Review 10.  How to control proteins with light in living systems.

Authors:  Arnaud Gautier; Carole Gauron; Michel Volovitch; David Bensimon; Ludovic Jullien; Sophie Vriz
Journal:  Nat Chem Biol       Date:  2014-07       Impact factor: 15.040
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