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Literature DB >> 27639090

Molecular tools for acute spatiotemporal manipulation of signal transduction.

Abstract

The biochemical activities involved in signal transduction in cells are under tight spatiotemporal regulation. To study the effects of the spatial patterning and temporal dynamics of biochemical activities on downstream signaling, researchers require methods to manipulate signaling pathways acutely and rapidly. In this review, we summarize recent developments in the design of three broad classes of molecular tools for perturbing signal transduction, classified by their type of input signal: chemically induced, optically induced, and magnetically induced.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2016 PMID： 27639090 PMCID： PMC5107343 DOI： 10.1016/j.cbpa.2016.08.012

Source DB: PubMed Journal: Curr Opin Chem Biol ISSN： 1367-5931 Impact factor: 8.822

59 in total

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Journal: Nat Mater Date: 2015-11-16 Impact factor: 43.841

2. Chemical development of intracellular protein heterodimerizers.

Authors: Dominik Erhart; Mirjam Zimmermann; Olivier Jacques; Matthias B Wittwer; Beat Ernst; Edwin Constable; Marketa Zvelebil; Florent Beaufils; Matthias P Wymann
Journal: Chem Biol Date: 2013-04-18

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Journal: Curr Biol Date: 1999-04-08 Impact factor: 10.834

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Journal: Pflugers Arch Date: 2013-01-09 Impact factor: 3.657

5. Light regulation of protein dimerization and kinase activity in living cells using photocaged rapamycin and engineered FKBP.

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Journal: J Am Chem Soc Date: 2010-12-16 Impact factor: 15.419

6. Light control of cellular processes by using photocaged abscisic acid.

Authors: Catherine W Wright; Zhi-Fo Guo; Fu-Sen Liang
Journal: Chembiochem Date: 2014-12-21 Impact factor: 3.164

7. Remote regulation of glucose homeostasis in mice using genetically encoded nanoparticles.

Authors: Sarah A Stanley; Jeremy Sauer; Ravi S Kane; Jonathan S Dordick; Jeffrey M Friedman
Journal: Nat Med Date: 2014-12-15 Impact factor: 53.440

8. Rapid blue-light-mediated induction of protein interactions in living cells.

Authors: Matthew J Kennedy; Robert M Hughes; Leslie A Peteya; Joel W Schwartz; Michael D Ehlers; Chandra L Tucker
Journal: Nat Methods Date: 2010-10-31 Impact factor: 28.547

9. Magnetic nanoparticles as mediators of ligand-free activation of EGFR signaling.

Authors: Atul A Bharde; Raghavendra Palankar; Cornelia Fritsch; Arjen Klaver; Johannes S Kanger; Thomas M Jovin; Donna J Arndt-Jovin
Journal: PLoS One Date: 2013-07-23 Impact factor: 3.240

10. Magnetogenetics: remote non-invasive magnetic activation of neuronal activity with a magnetoreceptor.

Authors: Xiaoyang Long; Jing Ye; Di Zhao; Sheng-Jia Zhang
Journal: Sci Bull (Beijing) Date: 2015-09-14 Impact factor: 11.780

5 in total

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Authors: Xin Zhou; Sohum Mehta; Jin Zhang
Journal: Curr Protoc Date: 2022-05