Literature DB >> 22645737

Using a nanopore for single molecule detection and single cell transfection.

Edward M Nelson1, Volker Kurz, Jiwook Shim, Winston Timp, Gregory Timp.   

Abstract

We assert that it is possible to trap and identify proteins, and even (conceivably) manipulate proteins secreted from a single cell (i.e. the secretome) through transfection via electroporation by exploiting the exquisite control over the electrostatic potential available in a nanopore. These capabilities may be leveraged for single cell analysis and transfection with single molecule resolution, ultimately enabling a careful scrutiny of tissue heterogeneity.

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Year:  2012        PMID： 22645737      PMCID： PMC3384492          DOI： 10.1039/c2an35571j

Source DB:  PubMed          Journal:  Analyst        ISSN： 0003-2654            Impact factor:   4.616


  39 in total

1.  Slowing DNA translocation in a solid-state nanopore.

Authors:  Daniel Fologea; James Uplinger; Brian Thomas; David S McNabb; Jiali Li
Journal:  Nano Lett       Date:  2005-09       Impact factor: 11.189

Review 2.  Approaches to the study of the cell secretome.

Authors:  Yetrib Hathout
Journal:  Expert Rev Proteomics       Date:  2007-04       Impact factor: 3.940

3.  Noise in solid-state nanopores.

Authors:  R M M Smeets; U F Keyser; N H Dekker; C Dekker
Journal:  Proc Natl Acad Sci U S A       Date:  2008-01-09       Impact factor: 11.205

4.  Transport of maltodextrins through maltoporin: a single-channel study.

Authors:  Lisen Kullman; Mathias Winterhalter; Sergey M Bezrukov
Journal:  Biophys J       Date:  2002-02       Impact factor: 4.033

5.  Electrical characterization of protein molecules by a solid-state nanopore.

Authors:  Daniel Fologea; Bradley Ledden; David S McNabb; Jiali Li
Journal:  Appl Phys Lett       Date:  2007-07-31       Impact factor: 3.791

6.  Dynamics of completely unfolded and native proteins through solid-state nanopores as a function of electric driving force.

Authors:  Abdelghani Oukhaled; Benjamin Cressiot; Laurent Bacri; Manuela Pastoriza-Gallego; Jean-Michel Betton; Eric Bourhis; Ralf Jede; Jacques Gierak; Loïc Auvray; Juan Pelta
Journal:  ACS Nano       Date:  2011-04-26       Impact factor: 15.881

7.  Characterization of individual polynucleotide molecules using a membrane channel.

Authors:  J J Kasianowicz; E Brandin; D Branton; D W Deamer
Journal:  Proc Natl Acad Sci U S A       Date:  1996-11-26       Impact factor: 11.205

Review 8.  Signal peptide-dependent protein transport in Bacillus subtilis: a genome-based survey of the secretome.

Authors:  H Tjalsma; A Bolhuis; J D Jongbloed; S Bron; J M van Dijl
Journal:  Microbiol Mol Biol Rev       Date:  2000-09       Impact factor: 11.056

Review 9.  The potential and challenges of nanopore sequencing.

Authors:  Daniel Branton; David W Deamer; Andre Marziali; Hagan Bayley; Steven A Benner; Thomas Butler; Massimiliano Di Ventra; Slaven Garaj; Andrew Hibbs; Xiaohua Huang; Stevan B Jovanovich; Predrag S Krstic; Stuart Lindsay; Xinsheng Sean Ling; Carlos H Mastrangelo; Amit Meller; John S Oliver; Yuriy V Pershin; J Michael Ramsey; Robert Riehn; Gautam V Soni; Vincent Tabard-Cossa; Meni Wanunu; Matthew Wiggin; Jeffery A Schloss
Journal:  Nat Biotechnol       Date:  2008-10       Impact factor: 54.908

10.  Identifying secretomes in people, pufferfish and pigs.

Authors:  Eric W Klee; Daniel F Carlson; Scott C Fahrenkrug; Stephen C Ekker; Lynda B M Ellis
Journal:  Nucleic Acids Res       Date:  2004-02-27       Impact factor: 16.971
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  11 in total

1.  Electro-optical detection of single λ-DNA.

Authors:  Shuo Liu; Thomas A Wall; Damla Ozcelik; Joshua W Parks; Aaron R Hawkins; Holger Schmidt
Journal:  Chem Commun (Camb)       Date:  2015-02-07       Impact factor: 6.222

2.  Resistive amplitude fingerprints during translocation of linear molecules through charged solid-state nanopores.

Authors:  Sebastian Sensale; Ceming Wang; Hsueh-Chia Chang
Journal:  J Chem Phys       Date:  2020-07-21       Impact factor: 3.488

3.  Micro-/nanofluidics based cell electroporation.

Authors:  Shengnian Wang; L James Lee
Journal:  Biomicrofluidics       Date:  2013-01-07       Impact factor: 2.800

4.  Reading the primary structure of a protein with 0.07 nm3 resolution using a subnanometre-diameter pore.

Authors:  Eamonn Kennedy; Zhuxin Dong; Clare Tennant; Gregory Timp
Journal:  Nat Nanotechnol       Date:  2016-07-25       Impact factor: 39.213

5.  Detection of methylation on dsDNA using nanopores in a MoS2 membrane.

Authors:  Jiwook Shim; Shouvik Banerjee; Hu Qiu; Kirby K H Smithe; David Estrada; Julian Bello; Eric Pop; Klaus Schulten; Rashid Bashir
Journal:  Nanoscale       Date:  2017-10-12       Impact factor: 7.790

Review 6.  Microfluidic electroporation for cellular analysis and delivery.

Authors:  Tao Geng; Chang Lu
Journal:  Lab Chip       Date:  2013-10-07       Impact factor: 6.799

Review 7.  Watching single proteins using engineered nanopores.

Authors:  Liviu Movileanu
Journal:  Protein Pept Lett       Date:  2014-03       Impact factor: 1.890

Review 8.  Recent advances in integrated solid-state nanopore sensors.

Authors:  Mahmudur Rahman; Mohammad Julker Neyen Sampad; Aaron Hawkins; Holger Schmidt
Journal:  Lab Chip       Date:  2021-06-17       Impact factor: 7.517

9.  Suitable transfection methods for single particle tracing in plant suspension cells.

Authors:  Janett Göhring; Nick Fulcher; Kurt Schilcher; Andrea Barta; Jaroslaw Jacak
Journal:  Plant Methods       Date:  2014-05-31       Impact factor: 4.993

Review 10.  Beyond mass spectrometry, the next step in proteomics.

Authors:  Winston Timp; Gregory Timp
Journal:  Sci Adv       Date:  2020-01-10       Impact factor: 14.136
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