OBJECTIVE: The objective of this study is to identify rates and factors associated with permanent diversion following restorative proctosigmoidectomy for rectal cancer when complicated by an anastomotic leak. DESIGN: This study is a retrospective review. SETTING: The setting of this study is a tertiary referral hospital PATIENTS: Patients involved in this study were those who underwent restorative rectal cancer surgery from 1997 through 2008 identified from an institutional cancer database. INTERVENTIONS: No interventions were performed in this study. MAIN OUTCOME MEASURES: Factors associated with time to ostomy closure and rates of permanent diversion following anastomotic leaks RESULTS: One hundred and thirty patients (mean age 59.7 years) were identified, 111 (85%) of whom had stoma diversion at the index surgery. Asymptomatic occult radiological leaks occurred in 52 patients (40%). Seventy-eight patients (60%) underwent ultimate ostomy closure at a median time of 6.3 months after the index surgery, which was not significantly affected by previous radiotherapy (p = 0.08). Twelve patients (9%) underwent anastomotic reconstruction. Pathologic stage II or greater (OR 4.42; 1.95-10.04), symptomatic presentation (OR 4.13; 1.86-9.19) and anastomotic disruption >5 mm (OR 4.42; 2.01-9.74) were independently associated with permanent diversion. Among all survivors, 33% did not have their ostomy reversed. Stoma diversion constructed after leak detection in 19 patients (15%) did not affect permanent stoma rate (OR 0.86; 0.31-2.34) or time to stoma closure (p = 0.29). CONCLUSIONS: The majority of anastomotic leaks after restorative rectal cancer surgery can be salvaged without anastomotic reconstruction. However, in one third of the patients, an anastomotic leak results in a permanent stoma.
OBJECTIVE: The objective of this study is to identify rates and factors associated with permanent diversion following restorative proctosigmoidectomy for rectal cancer when complicated by an anastomotic leak. DESIGN: This study is a retrospective review. SETTING: The setting of this study is a tertiary referral hospital PATIENTS: Patients involved in this study were those who underwent restorative rectal cancer surgery from 1997 through 2008 identified from an institutional cancer database. INTERVENTIONS: No interventions were performed in this study. MAIN OUTCOME MEASURES: Factors associated with time to ostomy closure and rates of permanent diversion following anastomotic leaks RESULTS: One hundred and thirty patients (mean age 59.7 years) were identified, 111 (85%) of whom had stoma diversion at the index surgery. Asymptomatic occult radiological leaks occurred in 52 patients (40%). Seventy-eight patients (60%) underwent ultimate ostomy closure at a median time of 6.3 months after the index surgery, which was not significantly affected by previous radiotherapy (p = 0.08). Twelve patients (9%) underwent anastomotic reconstruction. Pathologic stage II or greater (OR 4.42; 1.95-10.04), symptomatic presentation (OR 4.13; 1.86-9.19) and anastomotic disruption >5 mm (OR 4.42; 2.01-9.74) were independently associated with permanent diversion. Among all survivors, 33% did not have their ostomy reversed. Stoma diversion constructed after leak detection in 19 patients (15%) did not affect permanent stoma rate (OR 0.86; 0.31-2.34) or time to stoma closure (p = 0.29). CONCLUSIONS: The majority of anastomotic leaks after restorative rectal cancer surgery can be salvaged without anastomotic reconstruction. However, in one third of the patients, an anastomotic leak results in a permanent stoma.
Authors: Feza H Remzi; Victor W Fazio; Emre Gorgun; Massarat Zutshi; James M Church; Ian C Lavery; Tracy L Hull Journal: Dis Colon Rectum Date: 2005-04 Impact factor: 4.585
Authors: A Vignali; V W Fazio; I C Lavery; J W Milsom; J M Church; T L Hull; S A Strong; J R Oakley Journal: J Am Coll Surg Date: 1997-08 Impact factor: 6.113
Authors: B Lefebure; J J Tuech; V Bridoux; B Costaglioli; M Scotte; P Teniere; F Michot Journal: Int J Colorectal Dis Date: 2007-09-02 Impact factor: 2.571
Authors: M den Dulk; C A M Marijnen; L Collette; H Putter; L Påhlman; J Folkesson; J-F Bosset; C Rödel; K Bujko; C J H van de Velde Journal: Br J Surg Date: 2009-09 Impact factor: 6.939