Literature DB >> 22252797

NDM-4 metallo-β-lactamase with increased carbapenemase activity from Escherichia coli.

Patrice Nordmann1, Anne E Boulanger, Laurent Poirel.   

Abstract

A clinical Escherichia coli isolate resistant to all β-lactams, including carbapenems, expressed a novel metallo-β-lactamase (MBL), NDM-4, differing from NDM-1 by a single amino acid substitution (Met154Leu). NDM-4 possessed increased hydrolytic activity toward carbapenems and several cephalosporins compared to that of NDM-1. This amino acid substitution was not located in the known active sites of NDM-1, indicating that remote amino acid substitutions might also play a role in the extended activity of this MBL.

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Year:  2012        PMID： 22252797      PMCID： PMC3318389          DOI： 10.1128/AAC.05961-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

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4.  Carbapenem-hydrolyzing GES-type extended-spectrum beta-lactamase in Acinetobacter baumannii.

Authors:  Rémy A Bonnin; Patrice Nordmann; Anaïs Potron; Hervé Lecuyer; Jean-Ralph Zahar; Laurent Poirel
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  58 in total

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4.  Identification of a novel NDM variant, NDM-13, from a multidrug-resistant Escherichia coli clinical isolate in Nepal.

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5.  Evaluation of the New Multiplex Immunochromatographic O.K.N.V. K-SeT Assay for Rapid Detection of OXA-48-like, KPC, NDM, and VIM Carbapenemases.

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6.  NDM-8 metallo-β-lactamase in a multidrug-resistant Escherichia coli strain isolated in Nepal.

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Review 7.  Carbapenemases in Klebsiella pneumoniae and other Enterobacteriaceae: an evolving crisis of global dimensions.

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8.  Molecular Characterization and Computational Modelling of New Delhi Metallo-β-Lactamase-5 from an Escherichia coli Isolate (KOEC3) of Bovine Origin.

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Review 9.  NDM Metallo-β-Lactamases and Their Bacterial Producers in Health Care Settings.

Authors:  Wenjing Wu; Yu Feng; Guangmin Tang; Fu Qiao; Alan McNally; Zhiyong Zong
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10.  Distribution and Relationships of Antimicrobial Resistance Determinants among Extended-Spectrum-Cephalosporin-Resistant or Carbapenem-Resistant Escherichia coli Isolates from Rivers and Sewage Treatment Plants in India.

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