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Literature DB >> 20956589

Carbapenem-hydrolyzing GES-type extended-spectrum beta-lactamase in Acinetobacter baumannii.

Rémy A Bonnin¹, Patrice Nordmann, Anaïs Potron, Hervé Lecuyer, Jean-Ralph Zahar, Laurent Poirel.

Abstract

Acinetobacter baumannii isolate AP was recovered from a bronchial lavage of a patient hospitalized in Paris, France. A. baumannii AP was resistant to all β-lactams, including carbapenems, and produced the extended-spectrum β-lactamase (ESBL) GES-14, which differs from GES-1 by two substitutions, Gly170Ser and Gly243Ala. Cloning of the bla(GES-14) gene followed by its expression in Escherichia coli showed that GES-14 compromised significantly the efficacy of all β-lactams, including cephalosporins, aztreonam, and carbapenems. The carbapenemase activity of purified GES-14 was confirmed by kinetic studies. The bla(GES-14) gene was located into a class 1 integron structure and located onto a ca. 95-kb self-transferable plasmid. This study identified a very broad-spectrum β-lactamase in A. baumannii.

Entities: Chemical Species

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Year: 2010 PMID： 20956589 PMCID： PMC3019676 DOI： 10.1128/AAC.00773-10

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

28 in total

1. Biochemical sequence analyses of GES-1, a novel class A extended-spectrum beta-lactamase, and the class 1 integron In52 from Klebsiella pneumoniae.

Authors: L Poirel; I Le Thomas; T Naas; A Karim; P Nordmann
Journal: Antimicrob Agents Chemother Date: 2000-03 Impact factor: 5.191

2. IBC-1, a novel integron-associated class A beta-lactamase with extended-spectrum properties produced by an Enterobacter cloacae clinical strain.

Authors: P Giakkoupi; L S Tzouvelekis; A Tsakris; V Loukova; D Sofianou; E Tzelepi
Journal: Antimicrob Agents Chemother Date: 2000-09 Impact factor: 5.191

3. OXA-28, an extended-spectrum variant of OXA-10 beta-lactamase from Pseudomonas aeruginosa and its plasmid- and integron-located gene.

Authors: L Poirel; D Girlich; T Naas; P Nordmann
Journal: Antimicrob Agents Chemother Date: 2001-02 Impact factor: 5.191

4. GES-2, a class A beta-lactamase from Pseudomonas aeruginosa with increased hydrolysis of imipenem.

Authors: L Poirel; G F Weldhagen; T Naas; C De Champs; M G Dove; P Nordmann
Journal: Antimicrob Agents Chemother Date: 2001-09 Impact factor: 5.191

5. Factors affecting the isolation of CCC DNA from Streptomyces lividans and Escherichia coli.

Authors: T Kieser
Journal: Plasmid Date: 1984-07 Impact factor: 3.466

6. OXA-143, a novel carbapenem-hydrolyzing class D beta-lactamase in Acinetobacter baumannii.

Authors: Paul G Higgins; Laurent Poirel; Marlene Lehmann; Patrice Nordmann; Harald Seifert
Journal: Antimicrob Agents Chemother Date: 2009-09-21 Impact factor: 5.191

7. Molecular characterization of a cephamycin-hydrolyzing and inhibitor-resistant class A beta-lactamase, GES-4, possessing a single G170S substitution in the omega-loop.

Authors: Jun-ichi Wachino; Yohei Doi; Kunikazu Yamane; Naohiro Shibata; Tetsuya Yagi; Takako Kubota; Yoshichika Arakawa
Journal: Antimicrob Agents Chemother Date: 2004-08 Impact factor: 5.191

8. GES-11, a novel integron-associated GES variant in Acinetobacter baumannii.

Authors: Carole Moubareck; Sylvie Brémont; Marie-Christine Conroy; Patrice Courvalin; Thierry Lambert
Journal: Antimicrob Agents Chemother Date: 2009-05-18 Impact factor: 5.191

Review 9. Diversity, epidemiology, and genetics of class D beta-lactamases.

Authors: Laurent Poirel; Thierry Naas; Patrice Nordmann
Journal: Antimicrob Agents Chemother Date: 2009-08-31 Impact factor: 5.191

10. Relative strengths of the class 1 integron promoter hybrid 2 and the combinations of strong and hybrid 1 with an active p2 promoter.

Authors: Costas C Papagiannitsis; Leonidas S Tzouvelekis; Vivi Miriagou
Journal: Antimicrob Agents Chemother Date: 2008-11-10 Impact factor: 5.191

37 in total

1. Carbapenem-hydrolyzing GES-5-encoding gene on different plasmid types recovered from a bacterial community in a sewage treatment plant.

Authors: Delphine Girlich; Laurent Poirel; Rafael Szczepanowski; Andreas Schlüter; Patrice Nordmann
Journal: Appl Environ Microbiol Date: 2011-12-09 Impact factor: 4.792

2. Resources for Genetic and Genomic Analysis of Emerging Pathogen Acinetobacter baumannii.

Authors: Larry A Gallagher; Elizabeth Ramage; Eli J Weiss; Matthew Radey; Hillary S Hayden; Kiara G Held; Holly K Huse; Daniel V Zurawski; Mitchell J Brittnacher; Colin Manoil
Journal: J Bacteriol Date: 2015-04-06 Impact factor: 3.490

Review 3. Clinical and Pathophysiological Overview of Acinetobacter Infections: a Century of Challenges.

Authors: Darren Wong; Travis B Nielsen; Robert A Bonomo; Paul Pantapalangkoor; Brian Luna; Brad Spellberg
Journal: Clin Microbiol Rev Date: 2017-01 Impact factor: 26.132

4. GES-14-Producing Acinetobacter baumannii Isolates in a Neonatal Intensive Care Unit in Tunisia Are Associated with a Typical Middle East Clone and a Transferable Plasmid.

Authors: Aymen Mabrouk; Filipa Grosso; João Botelho; Wafa Achour; Assia Ben Hassen; Luisa Peixe
Journal: Antimicrob Agents Chemother Date: 2017-05-24 Impact factor: 5.191