| Literature DB >> 26169399 |
Basudha Shrestha1, Tatsuya Tada2, Tohru Miyoshi-Akiyama3, Kayo Shimada2, Hiroshi Ohara4, Teruo Kirikae5, Bharat M Pokhrel1.
Abstract
A novel New Delhi metallo-β-lactamase, NDM-13, was identified in a carbapenem-resistant Escherichia coli clinical isolate obtained from the urine of a patient in Nepal. The enzymatic activity of NDM-13 against β-lactams was similar to that of NDM-1. However, NDM-13 displayed significantly higher k cat/Km ratios for cefotaxime. The genetic environment of bla NDM-13 was determined to be tnpA-IS30-bla NDM-13-ble MBL-trpF-dsbC-cutA-groES-groL, with bla NDM-13 located within the chromosome.Entities:
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Year: 2015 PMID: 26169399 PMCID: PMC4538491 DOI: 10.1128/AAC.00332-15
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191