Literature DB >> 24687501

Biochemical analysis of metallo-β-lactamase NDM-3 from a multidrug-resistant Escherichia coli strain isolated in Japan.

Tatsuya Tada1, Tohru Miyoshi-Akiyama1, Kayo Shimada1, Teruo Kirikae2.   

Abstract

New Delhi metallo-β-lactamase-3 (NDM-3) was identified in a multidrug-resistant Escherichia coli isolate, NCGM77, obtained from the feces of a patient in Japan. The enzymatic activities of NDM-3 against β-lactams were similar to those of NDM-1, although NDM-3 showed slightly lower kcat/Km ratios for all the β-lactams tested except for doripenem. The genetic context for blaNDM-3 was tnpA-blaNDM-3-bleMBL-trpF-dsbC-tnpA-sulI-qacEdeltaI-aadA2-dfrA1, which was present on an approximately 250-kb plasmid.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID: 24687501      PMCID: PMC4068495          DOI: 10.1128/AAC.02793-13

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN: 0066-4804            Impact factor:   5.191


  29 in total

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3.  A Novel VIM-Type Metallo-β-Lactamase Variant, VIM-60, with Increased Hydrolyzing Activity against Fourth-Generation Cephalosporins in Pseudomonas aeruginosa Clinical Isolates in Japan.

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4.  Identification of a novel NDM variant, NDM-13, from a multidrug-resistant Escherichia coli clinical isolate in Nepal.

Authors:  Basudha Shrestha; Tatsuya Tada; Tohru Miyoshi-Akiyama; Kayo Shimada; Hiroshi Ohara; Teruo Kirikae; Bharat M Pokhrel
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5.  NDM-12, a novel New Delhi metallo-β-lactamase variant from a carbapenem-resistant Escherichia coli clinical isolate in Nepal.

Authors:  Tatsuya Tada; Basudha Shrestha; Tohru Miyoshi-Akiyama; Kayo Shimada; Hiroshi Ohara; Teruo Kirikae; Bharat M Pokhrel
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7.  Emergence of Various NDM-Type-Metallo-β-Lactamase-Producing Escherichia coli Clinical Isolates in Nepal.

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8.  Pseudomonas aeruginosa Clinical Isolates in Nepal Coproducing Metallo-β-Lactamases and 16S rRNA Methyltransferases.

Authors:  Tatsuya Tada; Kayo Shimada; Kazuhito Satou; Takashi Hirano; Bharat M Pokhrel; Jeevan B Sherchand; Teruo Kirikae
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Review 9.  B1-Metallo-β-Lactamases: Where Do We Stand?

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10.  IMP-51, a novel IMP-type metallo-β-lactamase with increased doripenem- and meropenem-hydrolyzing activities, in a carbapenem-resistant Pseudomonas aeruginosa clinical isolate.

Authors:  Tatsuya Tada; Pham Hong Nhung; Tohru Miyoshi-Akiyama; Kayo Shimada; Doan Mai Phuong; Nguyen Quoc Anh; Norio Ohmagari; Teruo Kirikae
Journal:  Antimicrob Agents Chemother       Date:  2015-08-17       Impact factor: 5.191

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