| Literature DB >> 24687501 |
Tatsuya Tada1, Tohru Miyoshi-Akiyama1, Kayo Shimada1, Teruo Kirikae2.
Abstract
New Delhi metallo-β-lactamase-3 (NDM-3) was identified in a multidrug-resistant Escherichia coli isolate, NCGM77, obtained from the feces of a patient in Japan. The enzymatic activities of NDM-3 against β-lactams were similar to those of NDM-1, although NDM-3 showed slightly lower kcat/Km ratios for all the β-lactams tested except for doripenem. The genetic context for blaNDM-3 was tnpA-blaNDM-3-bleMBL-trpF-dsbC-tnpA-sulI-qacEdeltaI-aadA2-dfrA1, which was present on an approximately 250-kb plasmid.Entities:
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Year: 2014 PMID: 24687501 PMCID: PMC4068495 DOI: 10.1128/AAC.02793-13
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191