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Literature DB >> 21930591

Evolutionary optimization of speed and accuracy of decoding on the ribosome.

Ingo Wohlgemuth¹, Corinna Pohl, Joerg Mittelstaet, Andrey L Konevega, Marina V Rodnina.

Abstract

Speed and accuracy of protein synthesis are fundamental parameters for the fitness of living cells, the quality control of translation, and the evolution of ribosomes. The ribosome developed complex mechanisms that allow for a uniform recognition and selection of any cognate aminoacyl-tRNA (aa-tRNA) and discrimination against any near-cognate aa-tRNA, regardless of the nature or position of the mismatch. This review describes the principles of the selection-kinetic partitioning and induced fit-and discusses the relationship between speed and accuracy of decoding, with a focus on bacterial translation. The translational machinery apparently has evolved towards high speed of translation at the cost of fidelity.

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Year: 2011 PMID： 21930591 PMCID： PMC3158919 DOI： 10.1098/rstb.2011.0138

Source DB: PubMed Journal: Philos Trans R Soc Lond B Biol Sci ISSN： 0962-8436 Impact factor: 6.237

68 in total

Evolutionary optimization of speed and accuracy of decoding on the ribosome.

1. Mutations at the accommodation gate of the ribosome impair RF2-dependent translation termination.

2. Missense suppressor mutations in 16S rRNA reveal the importance of helices h8 and h14 in aminoacyl-tRNA selection.

3. Structural rearrangements of the ribosome at the tRNA proofreading step.

4. Accommodation of aminoacyl-tRNA into the ribosome involves reversible excursions along multiple pathways.

5. A NusE:NusG complex links transcription and translation.

6. Cooperation between translating ribosomes and RNA polymerase in transcription elongation.

7. Conformational sampling of aminoacyl-tRNA during selection on the bacterial ribosome.

Review 8. Divergent stalling sequences sense and control cellular physiology.

9. Bacterial charity work leads to population-wide resistance.

10. The crystal structure of the ribosome bound to EF-Tu and aminoacyl-tRNA.

1. Real-Time Imaging Reveals Properties of Glutamate-Induced Arc/Arg 3.1 Translation in Neuronal Dendrites.

2. Ribosomal ambiguity made less ambiguous.

Review 3. Toward a Kinetic Understanding of Eukaryotic Translation.

4. Analysis of Translation Elongation Dynamics in the Context of an Escherichia coli Cell.

5. The chemical origins of life and its early evolution: an introduction.

6. Another look at mutations in ribosomal protein S4 lends strong support to the domain closure model.

Review 7. Emerging roles of tRNA in adaptive translation, signalling dynamics and disease.

Review 8. Translational Control under Stress: Reshaping the Translatome.

Review 9. Therapeutics based on stop codon readthrough.

10. Near Saturation of Ribosomal L7/L12 Binding Sites with Ternary Complexes in Slowly Growing E. coli.