PURPOSE: Appropriate use of SPECT imaging is regulated by evidence-based guidelines and appropriateness criteria in an effort to limit the burden of radiation administered to patients. We aimed at establishing whether the use of a low dose for stress-rest single-day nuclear myocardial perfusion imaging on an ultrafast (UF) cardiac gamma camera using cadmium-zinc-telluride solid-state detectors could be used routinely with the same accuracy obtained with standard doses and conventional cameras. METHODS: To this purpose, 137 consecutive patients (mean age 61 ± 8 years) with known or suspected coronary artery disease (CAD) were enrolled. They underwent single-day low-dose stress-rest myocardial perfusion imaging using UF SPECT and invasive coronary angiography. Patients underwent the first scan with a 7-min acquisition time 10 min after the end of the stress protocol (dose range 185 to 222 MBq of (99m)Tc-tetrofosmin). The rest scan (dose range 370 to 444 MBq of (99m)Tc-tetrofosmin) was acquired with a 6-min acquisition time. The mean summed stress scores (SSS) and mean summed rest scores (SRS) were obtained semiquantitatively. RESULTS: Coronary angiograms showed significant epicardial CAD in 83% of patients. Mean SSS and SRS were 10 ± 5 and 3 ± 3, respectively. Overall the area under the ROC curve for the SSS values was 0.904, while the areas under the ROC curves for each vascular territory were 0.982 for the left anterior descending artery, 0.931 for the left circumflex artery and 0.889 for the right coronary artery. CONCLUSION: This pilot study demonstrated the feasibility of a low-dose single-day stress-rest fasting protocol performed using UF SPECT, with good sensitivity and specificity in detecting CAD at low patient exposure, opening new perspectives in the use of myocardial perfusion in ischaemic patients.
PURPOSE: Appropriate use of SPECT imaging is regulated by evidence-based guidelines and appropriateness criteria in an effort to limit the burden of radiation administered to patients. We aimed at establishing whether the use of a low dose for stress-rest single-day nuclear myocardial perfusion imaging on an ultrafast (UF) cardiac gamma camera using cadmium-zinc-telluride solid-state detectors could be used routinely with the same accuracy obtained with standard doses and conventional cameras. METHODS: To this purpose, 137 consecutive patients (mean age 61 ± 8 years) with known or suspected coronary artery disease (CAD) were enrolled. They underwent single-day low-dose stress-rest myocardial perfusion imaging using UF SPECT and invasive coronary angiography. Patients underwent the first scan with a 7-min acquisition time 10 min after the end of the stress protocol (dose range 185 to 222 MBq of (99m)Tc-tetrofosmin). The rest scan (dose range 370 to 444 MBq of (99m)Tc-tetrofosmin) was acquired with a 6-min acquisition time. The mean summed stress scores (SSS) and mean summed rest scores (SRS) were obtained semiquantitatively. RESULTS: Coronary angiograms showed significant epicardial CAD in 83% of patients. Mean SSS and SRS were 10 ± 5 and 3 ± 3, respectively. Overall the area under the ROC curve for the SSS values was 0.904, while the areas under the ROC curves for each vascular territory were 0.982 for the left anterior descending artery, 0.931 for the left circumflex artery and 0.889 for the right coronary artery. CONCLUSION: This pilot study demonstrated the feasibility of a low-dose single-day stress-rest fasting protocol performed using UF SPECT, with good sensitivity and specificity in detecting CAD at low patient exposure, opening new perspectives in the use of myocardial perfusion in ischaemic patients.
Authors: Manuel D Cerqueira; Neil J Weissman; Vasken Dilsizian; Alice K Jacobs; Sanjiv Kaul; Warren K Laskey; Dudley J Pennell; John A Rumberger; Thomas Ryan; Mario S Verani Journal: Circulation Date: 2002-01-29 Impact factor: 29.690
Authors: Raymond J Gibbons; Gary J Balady; J Timothy Bricker; Bernard R Chaitman; Gerald F Fletcher; Victor F Froelicher; Daniel B Mark; Ben D McCallister; Aryan N Mooss; Michael G O'Reilly; William L Winters; Raymond J Gibbons; Elliott M Antman; Joseph S Alpert; David P Faxon; Valentin Fuster; Gabriel Gregoratos; Loren F Hiratzka; Alice K Jacobs; Richard O Russell; Sidney C Smith Journal: Circulation Date: 2002-10-01 Impact factor: 29.690
Authors: Salvador Borges-Neto; Robert A Pagnanelli; Linda K Shaw; Emily Honeycutt; Shuli C Shwartz; George L Adams; Ralph Edward Coleman Journal: J Nucl Cardiol Date: 2007-07 Impact factor: 5.952
Authors: E Gordon DePuey; Srinivas Bommireddipalli; John Clark; Anna Leykekhman; Linda B Thompson; Marvin Friedman Journal: J Nucl Cardiol Date: 2011-02-02 Impact factor: 5.952
Authors: T Sharir; D S Berman; P B Waechter; J Areeda; P B Kavanagh; J Gerlach; X Kang; G Germano Journal: J Nucl Med Date: 2001-11 Impact factor: 10.057
Authors: W Lane Duvall; Lori B Croft; Tapan Godiwala; Eric Ginsberg; Titus George; Milena J Henzlova Journal: J Nucl Cardiol Date: 2010-11-12 Impact factor: 5.952
Authors: Assuero Giorgetti; Massimiliano Rossi; Mario Stanislao; Guido Valle; Pietro Bertolaccini; Alberto Maneschi; Raffaele Giubbini; Maria Luisa De Rimini; Marco Mazzanti; Mario Cappagli; Elisa Milan; Duccio Volterrani; Paolo Marzullo Journal: J Nucl Med Date: 2007-09-14 Impact factor: 10.057
Authors: Alessia Gimelli; Giuseppe Rossi; Patrizia Landi; Paolo Marzullo; Giorgio Iervasi; Antonio L'abbate; Daniele Rovai Journal: J Nucl Med Date: 2009-03-16 Impact factor: 10.057
Authors: W Lane Duvall; Joseph M Sweeny; Lori B Croft; Eric Ginsberg; Krista A Guma; Milena J Henzlova Journal: J Nucl Cardiol Date: 2011-12-07 Impact factor: 5.952
Authors: Fabio P Esteves; James R Galt; Russell D Folks; Liudmila Verdes; Ernest V Garcia Journal: J Nucl Cardiol Date: 2013-11-28 Impact factor: 5.952