Alessia Gimelli1, Riccardo Liga2, Assuero Giorgetti1, Mirta Casagranda1, Paolo Marzullo1,3. 1. Fondazione Toscana G. Monasterio, Pisa, Italy. 2. Cardio-Thoracic and Vascular Department, University Hospital of Pisa, Via Paradisa 2, 56100, Pisa, Italy. riccardo.liga@gmail.com. 3. CNR, Institute of Clinical Physiology, Pisa, Italy.
Abstract
BACKGROUND: Abnormal left ventricular (LV) eccentricity index (EI) is a marker of adverse cardiac remodeling. However, the interaction between stress-induced alterations of EI and major cardiac parameters has not been explored. We sought to evaluate the relationship between LV EI and coronary artery disease (CAD) burden in patients submitted to myocardial perfusion imaging (MPI). METHODS AND RESULTS: Three-hundred and forty-three patients underwent MPI and coronary angiography. LV ejection fraction (EF) and EI were computed from gated stress images as measures of stress-induced functional impairment. One-hundred and thirty-six (40%), 122 (35%), and 85 (25%) patients had normal coronary arteries, single-vessel CAD, and multivessel CAD, respectively. Post-stress EI was lower in patients with multivessel CAD than in those with normal coronary arteries and single-vessel CAD (P = 0.001). This relationship was confirmed only in patients undergoing exercise stress test, where a lower post-stress EI predicted the presence of multivessel CAD (P = 0.039). CONCLUSIONS: Post-stress alterations of LV EI on MPI may unmask the presence of multivessel CAD.
BACKGROUND:Abnormal left ventricular (LV) eccentricity index (EI) is a marker of adverse cardiac remodeling. However, the interaction between stress-induced alterations of EI and major cardiac parameters has not been explored. We sought to evaluate the relationship between LV EI and coronary artery disease (CAD) burden in patients submitted to myocardial perfusion imaging (MPI). METHODS AND RESULTS: Three-hundred and forty-three patients underwent MPI and coronary angiography. LV ejection fraction (EF) and EI were computed from gated stress images as measures of stress-induced functional impairment. One-hundred and thirty-six (40%), 122 (35%), and 85 (25%) patients had normal coronary arteries, single-vessel CAD, and multivessel CAD, respectively. Post-stress EI was lower in patients with multivessel CAD than in those with normal coronary arteries and single-vessel CAD (P = 0.001). This relationship was confirmed only in patients undergoing exercise stress test, where a lower post-stress EI predicted the presence of multivessel CAD (P = 0.039). CONCLUSIONS: Post-stress alterations of LV EI on MPI may unmask the presence of multivessel CAD.
Authors: M Mazzanti; G Germano; H Kiat; P B Kavanagh; E Alexanderson; J D Friedman; R Hachamovitch; K F Van Train; D S Berman Journal: J Am Coll Cardiol Date: 1996-06 Impact factor: 24.094
Authors: Robert J H Miller; Tali Sharir; Yuka Otaki; Heidi Gransar; Joanna X Liang; Andrew J Einstein; Mathews B Fish; Terrence D Ruddy; Philipp A Kaufmann; Albert J Sinusas; Edward J Miller; Timothy M Bateman; Sharmila Dorbala; Marcelo Di Carli; Balaji K Tamarappoo; Damini Dey; Daniel S Berman; Piotr J Slomka Journal: J Nucl Med Date: 2021-03-12 Impact factor: 11.082