Literature DB >> 21431335

First experiences with semi-autonomous robotic harvesting of protein crystals.

Robert Viola1, Jace Walsh, Alex Melka, Wesley Womack, Sean Murphy, Alan Riboldi-Tunnicliffe, Bernhard Rupp.   

Abstract

The demonstration unit of the Universal Micromanipulation Robot (UMR) capable of semi-autonomous protein crystal harvesting has been tested and evaluated by independent users. We report the status and capabilities of the present unit scheduled for deployment in a high-throughput protein crystallization center. We discuss operational aspects as well as novel features such as micro-crystal handling and drip-cryoprotection, and we extrapolate towards the design of a fully autonomous, integrated system capable of reliable crystal harvesting. The positive to enthusiastic feedback from the participants in an evaluation workshop indicates that genuine demand exists and the effort and resources to develop autonomous protein crystal harvesting robotics are justified.

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Year:  2011        PMID： 21431335     DOI： 10.1007/s10969-011-9103-5

Source DB:  PubMed          Journal:  J Struct Funct Genomics        ISSN： 1345-711X


  20 in total

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Journal:  J Synchrotron Radiat       Date:  2005-12-22       Impact factor: 2.616

Review 4.  Automated robotic harvesting of protein crystals-addressing a critical bottleneck or instrumentation overkill?

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5.  High-throughput crystallization-to-structure pipeline at RIKEN SPring-8 Center.

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Review 9.  Structural genomics and drug discovery for infectious diseases.

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10.  The Center for Eukaryotic Structural Genomics.

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Journal:  J Struct Funct Genomics       Date:  2009-01-08
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  6 in total

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2.  Approaches to automated protein crystal harvesting.

Authors:  Marc C Deller; Bernhard Rupp
Journal:  Acta Crystallogr F Struct Biol Commun       Date:  2014-01-28       Impact factor: 1.056

3.  Acoustic transfer of protein crystals from agarose pedestals to micromeshes for high-throughput screening.

Authors:  Christina M Cuttitta; Daniel L Ericson; Alexander Scalia; Christian G Roessler; Ella Teplitsky; Karan Joshi; Olven Campos; Rakhi Agarwal; Marc Allaire; Allen M Orville; Robert M Sweet; Alexei S Soares
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2015-01-01

4.  Automated harvesting and processing of protein crystals through laser photoablation.

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Journal:  Acta Crystallogr D Struct Biol       Date:  2016-03-24       Impact factor: 7.652

5.  A comparison of gas stream cooling and plunge cooling of macromolecular crystals.

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Journal:  J Appl Crystallogr       Date:  2019-08-23       Impact factor: 3.304

6.  An evaluation of adhesive sample holders for advanced crystallographic experiments.

Authors:  Marco Mazzorana; Juan Sanchez-Weatherby; James Sandy; Carina M C Lobley; Thomas Sorensen
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2014-08-29
  6 in total

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