Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Cytidine deaminases: AIDing DNA demethylation?

Literature DB >> 20889711

Cytidine deaminases: AIDing DNA demethylation?

Abstract

The presence of 5-methylcytosine (5-mC) in DNA is a vital epigenetic mark in vertebrates. While the enzymes responsible for methylating DNA in vertebrates have been identified, the means by which this mark can be removed are still unclear. Recently, it has been shown that activation-induced cytidine deaminase (AID) contributes to the demethylation of DNA in certain systems. This enzyme has been intensely studied in its role as a key driver of antibody diversification in B cells, but recent observations from early development in zebrafish and mice as well as heterokaryons point to a role beyond immunology. This review takes stock of the reports linking AID and related deaminases to DNA demethylation, and describes the many important questions left to be answered in this field.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20889711 PMCID： PMC2947763 DOI： 10.1101/gad.1963010

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

74 in total

1. Demethylation of the zygotic paternal genome.

Authors: W Mayer; A Niveleau; J Walter; R Fundele; T Haaf
Journal: Nature Date: 2000-02-03 Impact factor: 49.962

Review 2. Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal.

Authors: Myriam Hemberger; Wendy Dean; Wolf Reik
Journal: Nat Rev Mol Cell Biol Date: 2009-07-15 Impact factor: 94.444

3. Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a.

Authors: B H Ramsahoye; D Biniszkiewicz; F Lyko; V Clark; A P Bird; R Jaenisch
Journal: Proc Natl Acad Sci U S A Date: 2000-05-09 Impact factor: 11.205

4. Active demethylation of the paternal genome in the mouse zygote.

Authors: J Oswald; S Engemann; N Lane; W Mayer; A Olek; R Fundele; W Dean; W Reik; J Walter
Journal: Curr Biol Date: 2000-04-20 Impact factor: 10.834

5. 5-Methylcytosine DNA glycosylase activity is also present in the human MBD4 (G/T mismatch glycosylase) and in a related avian sequence.

Authors: B Zhu; Y Zheng; H Angliker; S Schwarz; S Thiry; M Siegmann; J P Jost
Journal: Nucleic Acids Res Date: 2000-11-01 Impact factor: 16.971

6. X inactivation in the mouse embryo deficient for Dnmt1: distinct effect of hypomethylation on imprinted and random X inactivation.

Authors: T Sado; M H Fenner; S S Tan; P Tam; T Shioda; E Li
Journal: Dev Biol Date: 2000-09-15 Impact factor: 3.582

7. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme.

Authors: M Muramatsu; K Kinoshita; S Fagarasan; S Yamada; Y Shinkai; T Honjo
Journal: Cell Date: 2000-09-01 Impact factor: 41.582

Review 8. A coming-of-age story: activation-induced cytidine deaminase turns 10.

Authors: Rebecca K Delker; Sebastian D Fugmann; F Nina Papavasiliou
Journal: Nat Immunol Date: 2009-10-20 Impact factor: 25.606

9. DNA demethylation in hormone-induced transcriptional derepression.

Authors: Mi-Sun Kim; Takeshi Kondo; Ichiro Takada; Min-Young Youn; Yoko Yamamoto; Sayuri Takahashi; Takahiro Matsumoto; Sally Fujiyama; Yuko Shirode; Ikuko Yamaoka; Hirochika Kitagawa; Ken-ichi Takeyama; Hiroshi Shibuya; Fumiaki Ohtake; Shigeaki Kato
Journal: Nature Date: 2009-10-15 Impact factor: 49.962

10. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).

Authors: P Revy; T Muto; Y Levy; F Geissmann; A Plebani; O Sanal; N Catalan; M Forveille; R Dufourcq-Labelouse; A Gennery; I Tezcan; F Ersoy; H Kayserili; A G Ugazio; N Brousse; M Muramatsu; L D Notarangelo; K Kinoshita; T Honjo; A Fischer; A Durandy
Journal: Cell Date: 2000-09-01 Impact factor: 41.582

58 in total

1. APOBEC3 proteins and genomic stability: the high cost of a good defense.

Authors: Iñigo Narvaiza; Sébastien Landry; Matthew D Weitzman
Journal: Cell Cycle Date: 2012-01-01 Impact factor: 4.534

Review 2. Immunoglobulin class-switch DNA recombination: induction, targeting and beyond.

Authors: Zhenming Xu; Hong Zan; Egest J Pone; Thach Mai; Paolo Casali
Journal: Nat Rev Immunol Date: 2012-06-25 Impact factor: 53.106

Review 3. The curious chemical biology of cytosine: deamination, methylation, and oxidation as modulators of genomic potential.

Authors: Christopher S Nabel; Sara A Manning; Rahul M Kohli
Journal: ACS Chem Biol Date: 2011-10-31 Impact factor: 5.100

Cytidine deaminases: AIDing DNA demethylation?

1. Demethylation of the zygotic paternal genome.

Review 2. Epigenetic dynamics of stem cells and cell lineage commitment: digging Waddington's canal.

3. Non-CpG methylation is prevalent in embryonic stem cells and may be mediated by DNA methyltransferase 3a.

4. Active demethylation of the paternal genome in the mouse zygote.

5. 5-Methylcytosine DNA glycosylase activity is also present in the human MBD4 (G/T mismatch glycosylase) and in a related avian sequence.

6. X inactivation in the mouse embryo deficient for Dnmt1: distinct effect of hypomethylation on imprinted and random X inactivation.

7. Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme.

Review 8. A coming-of-age story: activation-induced cytidine deaminase turns 10.

9. DNA demethylation in hormone-induced transcriptional derepression.

10. Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2).

1. APOBEC3 proteins and genomic stability: the high cost of a good defense.

Review 2. Immunoglobulin class-switch DNA recombination: induction, targeting and beyond.

Review 3. The curious chemical biology of cytosine: deamination, methylation, and oxidation as modulators of genomic potential.

Review 4. Complex regulation and function of activation-induced cytidine deaminase.

Review 5. Mechanisms of epigenetic deregulation in lymphoid neoplasms.

Review 6. Mechanisms of specificity in neuronal activity-regulated gene transcription.

Review 7. Epigenetics, development, and cancer: zebrafish make their mark..

Review 8. Epigenetics of haematopoietic cell development.

Review 9. DNA methylation in development and disease: an overview for prostate researchers.

Review 10. DNA methylation dynamics in health and disease.